Thuốc Zydone (Oral)

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Thuốc Zydone (Oral)
Thuốc Zydone (Oral)

Holevn Health chia sẻ các bài viết về: Thuốc Zydone (Thuốc uống), tác dụng phụ – liều lượng, Thuốc Zydone (Thuốc uống) điều trị bệnh gì. Các vấn đề lưu ý khác. Vui lòng tham khảo các chi tiết dưới đây.

Tên chung: hydrocodone và acetaminophen (đường uống)

a-seet-a-MIN-oh-fen, hye-droe-KOE-bye-TAR-trate

Đường uống (Giải pháp)

Dung dịch uống hydrocodone bitartrate và acetaminophen có khả năng gây nghiện, lạm dụng và lạm dụng, có thể dẫn đến quá liều và tử vong. Đánh giá rủi ro của từng bệnh nhân trước khi kê đơn và theo dõi sự phát triển của các hành vi và điều kiện này. Để đảm bảo rằng lợi ích của thuốc giảm đau opioid vượt xa nguy cơ nghiện, lạm dụng và lạm dụng, Cục Quản lý Thực phẩm và Dược phẩm Hoa Kỳ (FDA) đã yêu cầu Chiến lược Đánh giá và Giảm thiểu Rủi ro (REMS) cho các sản phẩm này. Nghiêm trọng, đe dọa tính mạng hoặc suy hô hấp gây tử vong có thể xảy ra. Theo dõi chặt chẽ, đặc biệt là khi bắt đầu hoặc sau khi tăng liều. Việc vô tình uống hydrocodone bitartrate và dung dịch uống acetaminophen, đặc biệt là trẻ em, có thể dẫn đến quá liều gây ra hydrocodone bitartrate và acetaminophen. Việc sử dụng lâu dài hydrocodone bitartrate và dung dịch uống acetaminophen trong khi mang thai có thể dẫn đến hội chứng cai nghiện opioid ở trẻ sơ sinh, có thể đe dọa đến tính mạng nếu không được công nhận và điều trị. Theo dõi bệnh nhân dùng dung dịch uống hydrocodone bitartrate và acetaminophen và bất kỳ chất ức chế hoặc chất gây cảm ứng CYP3A4 nào cho các dấu hiệu suy hô hấp hoặc an thần. Acetaminophen có liên quan đến các trường hợp suy gan cấp tính, đôi khi dẫn đến ghép gan và tử vong, thường xuyên nhất là sử dụng acetaminophen với liều vượt quá 4000 mg / ngày và liên quan đến hơn 1 sản phẩm có chứa acetaminophen. Sử dụng đồng thời các thuốc benzodiazepin và opioid có thể dẫn đến an thần sâu sắc, suy hô hấp, hôn mê và tử vong. Dự trữ đồng thời kê đơn cho bệnh nhân với các lựa chọn điều trị thay thế không đầy đủ. Hạn chế liều lượng và thời lượng đến mức tối thiểu cần thiết và theo dõi bệnh nhân về các dấu hiệu và triệu chứng của suy hô hấp và an thần.

Đường uống (Máy tính bảng)

Hydrocodone bitartrate và acetaminophen có khả năng gây nghiện, lạm dụng và lạm dụng, có thể dẫn đến quá liều và tử vong. Đánh giá rủi ro của từng bệnh nhân trước khi kê đơn và theo dõi sự phát triển của các hành vi và điều kiện này. Để đảm bảo rằng lợi ích của thuốc giảm đau opioid vượt xa nguy cơ nghiện, lạm dụng và lạm dụng, Cục Quản lý Thực phẩm và Dược phẩm Hoa Kỳ (FDA) đã yêu cầu Chiến lược Đánh giá và Giảm thiểu Rủi ro (REMS) cho các sản phẩm này. Nghiêm trọng, đe dọa tính mạng hoặc suy hô hấp gây tử vong có thể xảy ra. Theo dõi chặt chẽ, đặc biệt là khi bắt đầu hoặc sau khi tăng liều. Việc vô tình uống hydrocodone bitartrate và acetaminophen, đặc biệt là trẻ em, có thể dẫn đến quá liều gây ra hydrocodone bitartrate và acetaminophen. Việc sử dụng hydrocodone bitartrate và acetaminophen kéo dài trong thai kỳ có thể dẫn đến hội chứng cai nghiện opioid ở trẻ sơ sinh, có thể đe dọa đến tính mạng nếu không được nhận biết và điều trị. Theo dõi bệnh nhân dùng hydrocodone bitartrate và acetaminophen và bất kỳ chất ức chế hoặc chất gây cảm ứng CYP3A4 nào cho các dấu hiệu suy hô hấp hoặc an thần. Acetaminophen có liên quan đến các trường hợp suy gan cấp tính, đôi khi dẫn đến ghép gan và tử vong, thường xuyên nhất là sử dụng acetaminophen với liều vượt quá 4000 mg / ngày và liên quan đến hơn 1 sản phẩm có chứa acetaminophen. Sử dụng đồng thời các thuốc benzodiazepin và opioid có thể dẫn đến an thần sâu sắc, suy hô hấp, hôn mê và tử vong. Dự trữ đồng thời kê đơn cho bệnh nhân với các lựa chọn điều trị thay thế không đầy đủ. Hạn chế liều lượng và thời lượng đến mức tối thiểu cần thiết và theo dõi bệnh nhân về các dấu hiệu và triệu chứng của suy hô hấp và an thần.

Holevn.org xem xét y tế. Cập nhật lần cuối vào ngày 19 tháng 10 năm 2019.

Tên thương hiệu thường được sử dụng

Tại Hoa Kỳ

  • Anexsia
  • Ceta Plus
  • Co-Gesic
  • Pháo đài Dolorex
  • Hycet
  • Lorcet
  • Lortab
  • Maxidone
  • Norco
  • Giai đoạn
  • Vicodin HP
  • Zydone

Các dạng bào chế có sẵn:

  • Giải pháp
  • Máy tính bảng
  • Thuốc tiên

Lớp trị liệu: Kết hợp Opioid / Acetaminophen

Lớp hóa học: Hydrocodone

Sử dụng cho Zydone

Kết hợp hydrocodone và acetaminophen được sử dụng để giảm đau đủ nghiêm trọng để điều trị opioid và khi các loại thuốc giảm đau khác không hoạt động đủ tốt hoặc không thể dung nạp được.

Acetaminophen được sử dụng để giảm đau và hạ sốt ở bệnh nhân. Nó không trở thành thói quen khi được thực hiện trong một thời gian dài. Nhưng acetaminophen có thể gây ra tác dụng không mong muốn khác khi dùng với liều lượng lớn, bao gồm cả tổn thương gan.

Hydrocodone thuộc nhóm thuốc gọi là thuốc giảm đau gây nghiện (thuốc giảm đau). Nó hoạt động trên hệ thống thần kinh trung ương (CNS) để giảm đau, và ngăn chặn hoặc ngăn ngừa ho.

Khi hydrocodone được sử dụng trong một thời gian dài, nó có thể trở thành thói quen, gây ra sự phụ thuộc về tinh thần hoặc thể chất. Tuy nhiên, những người bị đau liên tục không nên để nỗi sợ phụ thuộc ngăn họ sử dụng ma túy để giảm đau. Sự phụ thuộc tinh thần (nghiện) không có khả năng xảy ra khi ma túy được sử dụng cho mục đích này. Sự phụ thuộc về thể chất có thể dẫn đến tác dụng phụ khi rút thuốc nếu ngừng điều trị đột ngột. Tuy nhiên, tác dụng phụ nghiêm trọng khi cai thuốc thường có thể được ngăn chặn bằng cách giảm dần liều trong một khoảng thời gian trước khi ngừng điều trị hoàn toàn.

Thuốc này chỉ có sẵn trong một chương trình phân phối hạn chế được gọi là chương trình giảm đau Opioid REMS (Chiến lược đánh giá và giảm thiểu rủi ro).

Trước khi sử dụng Zydone

Khi quyết định sử dụng thuốc, rủi ro của việc dùng thuốc phải được cân nhắc với lợi ích mà nó sẽ làm. Đây là một quyết định mà bạn và bác sĩ của bạn sẽ đưa ra. Đối với thuốc này, cần xem xét những điều sau đây:

Dị ứng

Hãy cho bác sĩ của bạn nếu bạn đã từng có bất kỳ phản ứng bất thường hoặc dị ứng với thuốc này hoặc bất kỳ loại thuốc khác. Cũng nói với chuyên gia chăm sóc sức khỏe của bạn nếu bạn có bất kỳ loại dị ứng nào khác, chẳng hạn như thực phẩm, thuốc nhuộm, chất bảo quản hoặc động vật. Đối với các sản phẩm không kê đơn, đọc nhãn hoặc thành phần gói cẩn thận.

Nhi khoa

Nghiên cứu thích hợp chưa được thực hiện trên các mối quan hệ của tuổi ảnh hưởng của hydrocodone và kết hợp acetaminophen viên nangmáy tính bảng ở trẻ em. An toàn và hiệu quả chưa được thành lập.

Các nghiên cứu phù hợp được thực hiện cho đến nay đã không chứng minh được các vấn đề cụ thể ở trẻ em sẽ hạn chế tính hữu ích của dung dịch uống kết hợp hydrocodone và acetaminophen ở trẻ em từ 2 tuổi trở lên. Tuy nhiên, sự an toàn và hiệu quả chưa được thiết lập ở trẻ dưới 2 tuổi.

Lão

Các nghiên cứu phù hợp được thực hiện cho đến nay đã không chứng minh được các vấn đề cụ thể về lão khoa sẽ hạn chế tính hữu ích của sự kết hợp hydrocodone và acetaminophen ở người cao tuổi. Tuy nhiên, bệnh nhân cao tuổi có nhiều khả năng bị nhầm lẫn và buồn ngủ, và các vấn đề về gan, thận hoặc tim liên quan đến tuổi, có thể cần thận trọng và điều chỉnh liều cho bệnh nhân dùng kết hợp hydrocodone và acetaminophen.

Cho con bú

Không có nghiên cứu đầy đủ ở phụ nữ để xác định nguy cơ trẻ sơ sinh khi sử dụng thuốc này trong thời gian cho con bú. Cân nhắc lợi ích tiềm năng chống lại các rủi ro tiềm ẩn trước khi dùng thuốc này trong khi cho con bú.

Tương tác với thuốc

Mặc dù một số loại thuốc không nên được sử dụng cùng nhau, trong các trường hợp khác, hai loại thuốc khác nhau có thể được sử dụng cùng nhau ngay cả khi có thể xảy ra tương tác. Trong những trường hợp này, bác sĩ của bạn có thể muốn thay đổi liều, hoặc các biện pháp phòng ngừa khác có thể là cần thiết. Khi bạn đang dùng thuốc này, điều đặc biệt quan trọng là chuyên gia chăm sóc sức khỏe của bạn phải biết nếu bạn đang sử dụng bất kỳ loại thuốc nào được liệt kê dưới đây. Các tương tác sau đây đã được chọn trên cơ sở ý nghĩa tiềm năng của chúng và không nhất thiết phải bao gồm tất cả.

Sử dụng thuốc này với bất kỳ loại thuốc sau đây không được khuyến khích. Bác sĩ có thể quyết định không điều trị cho bạn bằng thuốc này hoặc thay đổi một số loại thuốc khác mà bạn dùng.

  • Nalmefene
  • Naltrexone
  • Safinamid

Sử dụng thuốc này với bất kỳ loại thuốc nào sau đây thường không được khuyến cáo, nhưng có thể được yêu cầu trong một số trường hợp. Nếu cả hai loại thuốc được kê đơn cùng nhau, bác sĩ có thể thay đổi liều hoặc tần suất bạn sử dụng một hoặc cả hai loại thuốc.

  • Acepromazine
  • Alfentanil
  • Almotriptan
  • Alprazolam
  • Amifampridine
  • Aminptine
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amitriptylinoxide
  • Amobarbital
  • Amoxapin
  • Amphetamine
  • Amprenavir
  • Anileridin
  • Aprepitant
  • Aripiprazole
  • Armodafinil
  • Asenapine
  • Atazanavir
  • Baclofen
  • Benperidol
  • Benzphetamine
  • Boceprevir
  • Bosentan
  • Bromazepam
  • Bromopride
  • Brompheniramine
  • Buprenorphin
  • Buspirone
  • Butabarbital
  • Butanol
  • Cần sa
  • Carbamazepin
  • Carbinoxamine
  • Carisoprodol
  • Carphenazine
  • Ceritinib
  • Cetirizin
  • Hydrat clo
  • Chlordiazepoxide
  • Clorpheniramine
  • Clorpromazine
  • Clorzoxazone
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codein
  • Conivaptan
  • Crizotinib
  • Xyclobenzaprine
  • Cyclosporine
  • Darunavir
  • Dasabuvir
  • Delavirdine
  • Desipramine
  • Desmopressin
  • Desvenlafaxine
  • Dexamethasone
  • Dexmedetomidin
  • Dextroamphetamine
  • Dextromethorphan
  • Thuốc khử trùng
  • Diazepam
  • Dibenzepin
  • Dichloralphenazone
  • Difenoxin
  • Dihydrocodeine
  • Diltiazem
  • Diphenhydramin
  • Diphenoxylate
  • Cá heo
  • Donepezil
  • Doxepin
  • Doxylamine
  • Dronedarone
  • Thuốc nhỏ giọt
  • Duloxetine
  • Efavirenz
  • Eletriptan
  • Enflurane
  • Enzalutamid
  • Erythromycin
  • Escitalopram
  • Esketamine
  • Acetate Eslicarbazepine
  • Estazolam
  • Eszopiclone
  • Ethchlorvynol
  • Ethopropazine
  • Ethylmorphin
  • Etravirine
  • Fentanyl
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluphenazine
  • Flurazepam
  • Fluspirilene
  • Fluvoxamine
  • Fosamprenavir
  • Chất khử trùng
  • Fosnetupitant
  • Fosphenytoin
  • Fospropofol
  • Frovatriptan
  • Tapentadol
  • Telaprevir
  • Telithromycin
  • Temazepam
  • Thiethylperazine
  • Thiopental
  • Thiopropazate
  • Thioridazine
  • Tianeptine
  • Tilidine
  • Tizanidine
  • Tolonium Chloride
  • Topiramate
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Triazolam
  • Trifluoperazine
  • Trifluperidol
  • Triflupromazine
  • Trimeprazine
  • Trimipramine
  • Tryptophan
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Zaleplon
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Zopiclone
  • Zotepine
  • Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

    • Acenocoumarol
    • Carbamazepine
    • Fosphenytoin
    • Lixisenatide
    • Phenytoin
    • Warfarin
    • Zidovudine

    Interactions with food/tobacco/alcohol

    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

    • Ethanol
    • Grapefruit Juice
    • Tobacco

    Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

    • Cabbage

    Other medical problems

    The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

    • Addison’s disease (adrenal gland problem) or
    • Alcohol abuse, history of or
    • Brain tumor, or history of or
    • Breathing or lung problems (eg, asthma, apnea, chronic obstructive pulmonary disease [COPD], cor pulmonale, emphysema, hypoxia) or
    • CNS depression or
    • Drug dependence, especially narcotic abuse or dependence, or history of or
    • Enlarged prostate (BPH, prostatic hypertrophy) or
    • Head injuries, or history of or
    • Increased pressure in the head or
    • Hypothyroidism (an underactive thyroid) or
    • Problems with passing urine—Use with caution. May increase risk for more serious side effects.
    • Hypotension (low blood pressure) or
    • Pancreatitis (swelling of the pancreas) or
    • Seizures, history of—Use with caution. May make these conditions worse.
    • Kidney disease or
    • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
    • Lung disease or breathing problems, severe or
    • Stomach or bowel blockage (eg, paralytic ileus)—Should not be used in patients with these conditions.

    Proper use of Zydone

    This section provides information on the proper use of a number of products that contain hydrocodone and acetaminophen. It may not be specific to Zydone. Please read with care.

    Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose. Large amounts of acetaminophen may cause liver damage.

    It is very important that you understand the rules of the Opioid Analgesic REMS program to prevent addiction, abuse, and misuse of hydrocodone and acetaminophen combination. This medicine should also come with a Medication Guide and patient information leaflet. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. Ask your doctor if you have any questions.

    Measure the oral liquid with a marked measuring spoon, oral syringe, dropper, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

    This combination medicine contains acetaminophen (Tylenol®). Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).

    Dosing

    The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    For moderate to severe pain:

  • For oral dosage form (capsules):
    • Adults—1 or 2 capsules every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 8 capsules per day.
    • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (elixir):
    • Adults and children 14 years of age and older and weighing 46 kilograms (kg) and more—11.25 milliliters (mL) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 67.5 mL per day.
    • Children 10 to 13 years of age and weighing 32 to 45 kg—7.5 mL every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 45 mL per day.
    • Children 7 to 9 years of age and weighing 23 to 31 kg—5.6 mL every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 33.6 mL per day.
    • Children 4 to 6 years of age and weighing 16 to 22 kg—3.75 mL every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 22.5 mL per day.
    • Children 2 to 3 years of age and weighing 12 to 15 kg—2.8 mL every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 16.8 mL per day.
    • Children younger than 2 years of age—Use and dose must be determined by your doctor.
  • For oral dosage form (7.5 milligrams [mg] per 325 mg per 15 mL solution):
    • Adults and children 14 years of age and older and weighing 46 kg and more—15 milliliters (mL) or 1 tablespoonful every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mL (6 tablespoonfuls) per day.
    • Children 10 to 13 years of age and weighing 32 to 45 kg—10 mL (2 teaspoonfuls) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 60 mL (12 teaspoonfuls) per day.
    • Children 7 to 9 years of age and weighing 23 to 31 kg—7.5 mL (1 and 1/2 teaspoonfuls) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 45 mL (9 teaspoonfuls) per day.
    • Children 4 to 6 years of age and weighing 16 to 22 kg—5 mL (1 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 30 mL (6 teaspoonfuls) per day.
    • Children 2 to 3 years of age and weighing 12 to 15 kg—3.75 mL (3/4 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 22.5 mL (4 and 1/2 teaspoonfuls) per day.
    • Children younger than 2 years of age—Use and dose must be determined by your doctor.
  • For oral dosage form (10 milligrams [mg] per 325 mg per 15 mL solution):
    • Adults—15 milliliters (mL) or 1 tablespoonful every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mL (6 tablespoonfuls) per day.
    • Children 14 years of age and older and weighing 46 kg and more—11.25 mL (2 and 1/4 teaspoonfuls) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 67.5 mL (13 and 1/2 teaspoonfuls) per day.
    • Children 10 to 13 years of age and weighing 32 to 45 kg—7.5 mL (1 and 1/2 teaspoonfuls) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 45 mL (9 teaspoonfuls) per day.
    • Children 7 to 9 years of age and weighing 23 to 31 kg—5.6 mL (1 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 33.6 mL (6 and 1/2 teaspoonfuls) per day.
    • Children 4 to 6 years of age and weighing 16 to 22 kg—3.75 mL (3/4 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 22.5 mL (4 and 1/2 teaspoonfuls) per day.
    • Children 2 to 3 years of age and weighing 12 to 15 kg—2.8 mL (1/2 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 16.8 mL (3 and 1/4 teaspoonfuls) per day.
    • Children younger than 2 years of age—Use and dose must be determined by your doctor.
  • For oral dosage form (5 milligrams [mg] per 325 mg tablets):
    • Adults—
      • Lortab®: 1 or 2 tablets every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 12 tablets per day.
      • Norco® 5/325: 1 or 2 tablets every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 8 tablets per day.
      • Generic: Dose depends on the strength of the tablet and must be determined by your doctor.
    • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (7.5 mg per 325 mg tablets):
    • Adults—
      • Lortab®: 1 tablet every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 6 tablets per day.
      • Norco® 7.5/325: 1 tablet every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 6 tablets per day.
      • Generic: Dose depends on the strength of the tablet and must be determined by your doctor.
    • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (10 mg per 325 mg tablets):
    • Adults—
      • Lortab®: 1 tablet every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 6 tablets per day.
      • Norco® 10/325: 1 tablet every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 6 tablets per day.
      • Generic: Dose depends on the strength of the tablet and must be determined by your doctor.
    • Children—Use and dose must be determined by your doctor.
  • Missed dose

    If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    If you miss a dose of hydrocodone and acetaminophen oral solution or Norco®, skip the missed dose and go back to your regular dosing schedule.

    Storage

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

    Keep out of the reach of children.

    Do not keep outdated medicine or medicine no longer needed.

    Hydrocodone can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines. Make sure you store the medicine in a safe and secure place to prevent others from getting it.

    Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm .

    Precautions while using Zydone

    It is very important that your doctor check your or your child’s progress while using this medicine, especially within the first 24 to 72 hours of treatment. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to take it. Blood and urine tests may be needed to check for unwanted effects.

    Do not use this medicine if you are using or have used an MAO inhibitor (eg, isocarboxazid [Marplan®], linezolid [Zyvox®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]) within the past 14 days.

    It is against the law and dangerous for anyone else to use your medicine. Keep your unused tablets in a safe and secure place. People who are addicted to drugs might want to steal this medicine.

    This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics (numbing medicines), including some dental anesthetics. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine.

    This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose.

    Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

    Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.

    This medicine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

    This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

    Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

    Before you or your child have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of certain tests may be affected by this medicine.

    Do not change your dose or suddenly stop using this medicine without first checking with your doctor. Your doctor may want you or your child to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.

    Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn baby. Tell your doctor right away if your child has the following symptoms: an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, sneezing, weight loss, vomiting, yawning, or failure to gain weight.

    Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

    Using too much of this medicine may cause infertility (unable to have children). Talk with your doctor before using this medicine if you plan to have children.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

    Zydone side effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:

    More common

    • Dizziness
    • lightheadedness

    Incidence not known

    • Back, leg, or stomach pains
    • black, tarry stools
    • bleeding gums
    • blood in the urine or stools
    • blood in vomit
    • bluish lips or skin
    • chills
    • choking
    • cough
    • dark urine
    • decrease in the frequency of urination
    • decrease in urine volume
    • difficult or troubled breathing
    • difficulty in passing urine (dribbling)
    • difficulty with swallowing
    • fast heartbeat
    • fever
    • fever with or without chills
    • general body swelling
    • general feeling of tiredness or weakness
    • headache
    • hoarseness
    • irregular, fast or slow, or shallow breathing
    • light-colored stools
    • loss of appetite
    • lower back or side pain
    • nausea
    • nosebleeds
    • not breathing
    • painful or difficult urination
    • pale or blue lips, fingernails, or skin
    • pinpoint red spots on the skin
    • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    • severe or continuing stomach pain
    • skin rash, hives, or itching
    • sore throat
    • sore tongue
    • sores, ulcers, or white spots on the lips or in the mouth
    • tightness in the chest
    • unable to speak
    • unusual bleeding or bruising
    • unusual tiredness or weakness
    • upper right abdominal or stomach pain
    • vomiting
    • yellow eyes and skin

    Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of overdose

    • Bloody or cloudy urine
    • change in consciousness
    • chest pain or discomfort
    • cold and clammy skin
    • decreased awareness or responsiveness
    • extreme drowsiness
    • general feeling of discomfort or illness
    • increased sweating
    • irregular heartbeat
    • lightheadedness, dizziness, or fainting
    • loss of consciousness
    • no blood pressure or pulse
    • no muscle tone or movement
    • not breathing
    • severe sleepiness
    • slow or irregular heartbeat
    • stopping of heart
    • sudden decrease in the amount of urine
    • unpleasant breath odor

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    More common

    • Drowsiness
    • relaxed and calm feeling
    • sleepiness

    Incidence not known

    • Belching
    • changes in mood
    • difficulty having a bowel movement
    • fear or nervousness
    • feeling of indigestion
    • hearing loss
    • impaired hearing
    • pain in the chest below the breastbone
    • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Seek emergency medical attention or call 115

    Further information

    The content of Holevn is solely for the purpose of providing information about Thuốc Zydone (Oral)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

    Reference from: https://www.drugs.com/cons/zydone.html

  • Prazepam
  • Prednisone
  • Pregabalin
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propofol
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Ramelteon
  • Ranitidine
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Remoxipride
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
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  • Saquinavir
  • Scopolamine
  • Secobarbital
  • Selegiline
  • Sertindole
  • Sertraline
  • Sibutramine
  • Sodium Oxybate
  • St John’s Wort
  • Sufentanil
  • Sulpiride
  • Sumatriptan
  • Suvorexant
  • Tapentadol
  • Telaprevir
  • Telithromycin
  • Temazepam
  • Thiethylperazine
  • Thiopental
  • Thiopropazate
  • Thioridazine
  • Tianeptine
  • Tilidine
  • Tizanidine
  • Tolonium Chloride
  • Topiramate
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Triazolam
  • Trifluoperazine
  • Trifluperidol
  • Triflupromazine
  • Trimeprazine
  • Trimipramine
  • Tryptophan
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Zaleplon
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Zopiclone
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Carbamazepine
  • Fosphenytoin
  • Lixisenatide
  • Phenytoin
  • Warfarin
  • Zidovudine

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol
  • Grapefruit Juice
  • Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Cabbage

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Addison’s disease (adrenal gland problem) or
  • Alcohol abuse, history of or
  • Brain tumor, or history of or
  • Breathing or lung problems (eg, asthma, apnea, chronic obstructive pulmonary disease [COPD], cor pulmonale, emphysema, hypoxia) or
  • CNS depression or
  • Drug dependence, especially narcotic abuse or dependence, or history of or
  • Enlarged prostate (BPH, prostatic hypertrophy) or
  • Head injuries, or history of or
  • Increased pressure in the head or
  • Hypothyroidism (an underactive thyroid) or
  • Problems with passing urine—Use with caution. May increase risk for more serious side effects.
  • Hypotension (low blood pressure) or
  • Pancreatitis (swelling of the pancreas) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Lung disease or breathing problems, severe or
  • Stomach or bowel blockage (eg, paralytic ileus)—Should not be used in patients with these conditions.

Proper use of Zydone

This section provides information on the proper use of a number of products that contain hydrocodone and acetaminophen. It may not be specific to Zydone. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose. Large amounts of acetaminophen may cause liver damage.

It is very important that you understand the rules of the Opioid Analgesic REMS program to prevent addiction, abuse, and misuse of hydrocodone and acetaminophen combination. This medicine should also come with a Medication Guide and patient information leaflet. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. Ask your doctor if you have any questions.

Measure the oral liquid with a marked measuring spoon, oral syringe, dropper, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

This combination medicine contains acetaminophen (Tylenol®). Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For moderate to severe pain:

    • For oral dosage form (capsules):
      • Adults—1 or 2 capsules every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 8 capsules per day.
      • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (elixir):
      • Adults and children 14 years of age and older and weighing 46 kilograms (kg) and more—11.25 milliliters (mL) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 67.5 mL per day.
      • Children 10 to 13 years of age and weighing 32 to 45 kg—7.5 mL every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 45 mL per day.
      • Children 7 to 9 years of age and weighing 23 to 31 kg—5.6 mL every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 33.6 mL per day.
      • Children 4 to 6 years of age and weighing 16 to 22 kg—3.75 mL every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 22.5 mL per day.
      • Children 2 to 3 years of age and weighing 12 to 15 kg—2.8 mL every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 16.8 mL per day.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For oral dosage form (7.5 milligrams [mg] per 325 mg per 15 mL solution):
      • Adults and children 14 years of age and older and weighing 46 kg and more—15 milliliters (mL) or 1 tablespoonful every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mL (6 tablespoonfuls) per day.
      • Children 10 to 13 years of age and weighing 32 to 45 kg—10 mL (2 teaspoonfuls) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 60 mL (12 teaspoonfuls) per day.
      • Children 7 to 9 years of age and weighing 23 to 31 kg—7.5 mL (1 and 1/2 teaspoonfuls) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 45 mL (9 teaspoonfuls) per day.
      • Children 4 to 6 years of age and weighing 16 to 22 kg—5 mL (1 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 30 mL (6 teaspoonfuls) per day.
      • Children 2 to 3 years of age and weighing 12 to 15 kg—3.75 mL (3/4 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 22.5 mL (4 and 1/2 teaspoonfuls) per day.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For oral dosage form (10 milligrams [mg] per 325 mg per 15 mL solution):
      • Adults—15 milliliters (mL) or 1 tablespoonful every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mL (6 tablespoonfuls) per day.
      • Children 14 years of age and older and weighing 46 kg and more—11.25 mL (2 and 1/4 teaspoonfuls) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 67.5 mL (13 and 1/2 teaspoonfuls) per day.
      • Children 10 to 13 years of age and weighing 32 to 45 kg—7.5 mL (1 and 1/2 teaspoonfuls) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 45 mL (9 teaspoonfuls) per day.
      • Children 7 to 9 years of age and weighing 23 to 31 kg—5.6 mL (1 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 33.6 mL (6 and 1/2 teaspoonfuls) per day.
      • Children 4 to 6 years of age and weighing 16 to 22 kg—3.75 mL (3/4 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 22.5 mL (4 and 1/2 teaspoonfuls) per day.
      • Children 2 to 3 years of age and weighing 12 to 15 kg—2.8 mL (1/2 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 16.8 mL (3 and 1/4 teaspoonfuls) per day.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For oral dosage form (5 milligrams [mg] per 325 mg tablets):
      • Adults—
        • Lortab®: 1 or 2 tablets every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 12 tablets per day.
        • Norco® 5/325: 1 or 2 tablets every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 8 tablets per day.
        • Generic: Dose depends on the strength of the tablet and must be determined by your doctor.
      • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (7.5 mg per 325 mg tablets):
      • Adults—
        • Lortab®: 1 tablet every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 6 tablets per day.
        • Norco® 7.5/325: 1 tablet every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 6 tablets per day.
        • Generic: Dose depends on the strength of the tablet and must be determined by your doctor.
      • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (10 mg per 325 mg tablets):
      • Adults—
        • Lortab®: 1 tablet every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 6 tablets per day.
        • Norco® 10/325: 1 tablet every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 6 tablets per day.
        • Generic: Dose depends on the strength of the tablet and must be determined by your doctor.
      • Children—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of hydrocodone and acetaminophen oral solution or Norco®, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Hydrocodone can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines. Make sure you store the medicine in a safe and secure place to prevent others from getting it.

Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm .

Precautions while using Zydone

It is very important that your doctor check your or your child’s progress while using this medicine, especially within the first 24 to 72 hours of treatment. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to take it. Blood and urine tests may be needed to check for unwanted effects.

Do not use this medicine if you are using or have used an MAO inhibitor (eg, isocarboxazid [Marplan®], linezolid [Zyvox®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]) within the past 14 days.

It is against the law and dangerous for anyone else to use your medicine. Keep your unused tablets in a safe and secure place. People who are addicted to drugs might want to steal this medicine.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics (numbing medicines), including some dental anesthetics. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.

This medicine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

Before you or your child have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of certain tests may be affected by this medicine.

Do not change your dose or suddenly stop using this medicine without first checking with your doctor. Your doctor may want you or your child to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.

Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn baby. Tell your doctor right away if your child has the following symptoms: an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, sneezing, weight loss, vomiting, yawning, or failure to gain weight.

Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

Using too much of this medicine may cause infertility (unable to have children). Talk with your doctor before using this medicine if you plan to have children.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Zydone side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Dizziness
  • lightheadedness

Incidence not known

  • Back, leg, or stomach pains
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blood in vomit
  • bluish lips or skin
  • chills
  • choking
  • cough
  • dark urine
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or troubled breathing
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing
  • fast heartbeat
  • fever
  • fever with or without chills
  • general body swelling
  • general feeling of tiredness or weakness
  • headache
  • hoarseness
  • irregular, fast or slow, or shallow breathing
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • nausea
  • nosebleeds
  • not breathing
  • painful or difficult urination
  • pale or blue lips, fingernails, or skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe or continuing stomach pain
  • skin rash, hives, or itching
  • sore throat
  • sore tongue
  • sores, ulcers, or white spots on the lips or in the mouth
  • tightness in the chest
  • unable to speak
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • vomiting
  • yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  • Bloody or cloudy urine
  • change in consciousness
  • chest pain or discomfort
  • cold and clammy skin
  • decreased awareness or responsiveness
  • extreme drowsiness
  • general feeling of discomfort or illness
  • increased sweating
  • irregular heartbeat
  • lightheadedness, dizziness, or fainting
  • loss of consciousness
  • no blood pressure or pulse
  • no muscle tone or movement
  • not breathing
  • severe sleepiness
  • slow or irregular heartbeat
  • stopping of heart
  • sudden decrease in the amount of urine
  • unpleasant breath odor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Drowsiness
  • relaxed and calm feeling
  • sleepiness

Incidence not known

  • Belching
  • changes in mood
  • difficulty having a bowel movement
  • fear or nervousness
  • feeling of indigestion
  • hearing loss
  • impaired hearing
  • pain in the chest below the breastbone
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Zydone (Oral)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/zydone.html

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