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Generic Name: hepatitis a and hepatitis b vaccine (Intramuscular route)
hep-a-TYE-tis A VAX-een, in-AK-ti-vay-ted, hep-a-TYE-tis B VAX-een re-KOM-bin-ant
Medically reviewed by Holevn.org. Last updated on Sep 1, 2019.
Commonly used brand name(s)
In the U.S.
- Twinrix Adult
- Twinrix Junior
Available Dosage Forms:
Therapeutic Class: Vaccine
Uses for Twinrix Adult
Hepatitis A and hepatitis B combination vaccine is used to prevent infection caused by the hepatitis A and hepatitis B virus. The vaccine works by causing your body to produce its own protection (antibodies) against the disease.
Hepatitis A is a serious disease of the liver that can cause death. It is caused by the hepatitis A virus (HAV), and is spread most often through infected food or water. Hepatitis A may also be spread by close person-to-person contact with infected persons (such as between persons living in the same household). Although some infected persons do not appear to be sick, they are still able to spread the virus to others.
Hepatitis A is less common in the U.S. and other areas of the world that have a higher level of sanitation and good water and sewage (waste) systems. However, it is a significant health problem in parts of the world that do not have such systems. If you are traveling to certain countries or remote (out-of-the-way) areas, hepatitis A vaccine will help protect you from hepatitis A disease.
Hepatitis B is caused by hepatitis B virus (HBV), and is spread by contact with body fluids, such as blood, saliva, semen, or vaginal fluids; by needle sticks or sharing needles; or from mother to child.
Hepatitis A and hepatitis B combination vaccine is recommended for all persons 18 years of age or older who are at risk from infection from their jobs or some behaviors, or from traveling to the following parts of the world:
- Central and South America.
- Eastern and Southern Europe.
- South and Southeast Asia (except Japan).
- The Caribbean.
- The Middle East.
- The former Soviet Union
Hepatitis A and Hepatitis B combination vaccine is also recommended for:
- Military personnel.
- Persons living in or moving to areas that have a high rate of HAV infection and who are at a high risk of HBV infection.
- Persons engaging in high-risk sexual activity, such as homosexual and bisexual males.
- Persons who use illegal injection drugs.
- Persons at risk through their work, such as laboratory workers who handle live hepatitis A and hepatitis B virus, police, and those who give first aid or medical help, and workers who come in contact with stool or sewage.
- People who work in child daycare centers and correctional facilities, residents of drug and alcohol treatment centers, and patients and staff in hemodialysis units.
- People who are at increased risk for HBV infection and who are in close contact with patients that have hepatitis A or B.
- Persons with hemophilia.
- Persons with chronic liver disease.
This vaccine is to be given only by or under the supervision of a doctor.
Before using Twinrix Adult
In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of hepatitis A and hepatitis B combination vaccine in the pediatric population. Safety and efficacy have not been established.
Appropriate studies on the relationship of age to the effects of hepatitis A and hepatitis B combination vaccine have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to neomycin or
- Allergy to yeast—Should not be used in patients with these conditions.
- Moderate or severe illness with fever—Your dose may need to be given at a later time.
- Weak immune system from a disease or medicine—The vaccine may not work as well in patients with this condition.
Proper use of Twinrix Adult
This section provides information on the proper use of a number of products that contain hepatitis a and hepatitis b vaccine. It may not be specific to Twinrix Adult. Please read with care.
A nurse or other trained health professional will give you this vaccine. This vaccine is given as a shot into your muscles.
This vaccine is usually given as 3 doses. After the first dose, two more doses are given 1 month and 6 months after the first dose, unless your doctor tells you otherwise.
It is important that you receive all doses at the right time. If you miss your scheduled shot, call your doctor to make another appointment as soon as possible.
Precautions while using Twinrix Adult
It is very important that you return to your doctor’s office at the right time for all of the doses. Be sure to notify your doctor of any unwanted effects that occur after you receive this vaccine.
This vaccine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, swelling of the tongue and throat, or trouble breathing after you get the injection.
Tell your doctor if you are allergic to latex. The needle cover and the rubber plunger of the prefilled syringe contains dry natural latex rubber, which may cause an allergic reaction in people with a latex allergy.
This vaccine may not protect you against hepatitis A or hepatitis B infection if you are already infected with the virus at the time you receive the shot.
Twinrix Adult side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Fever more than 99.5 degrees F
- unusual tiredness or weakness
- Difficulty with breathing or swallowing
- itching, especially of the hands or feet
- reddening of the skin, especially around the ears
- swelling of the eyes, face, or inside of the nose
- unusual tiredness or weakness (sudden and severe)
Incidence not known
- back pain
- being forgetful
- black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- bloody nose
- blurred vision
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- convulsions or seizures
- dark urine
- difficulty controlling your bladder or bowels
- difficulty with walking
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling of discomfort
- feeling sad or depressed
- general feeling of illness
- general tiredness and weakness
- heavier menstrual periods
- inability to move the arms and legs
- increased sweating
- inflammation of the joints
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- muscle aches or cramps
- nausea or vomiting
- numbness or tingling in your arms, face, hands, or legs
- partial or slight paralysis
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, irritated eyes
- redness, soreness, or itching skin
- severe headache
- shortness of breath
- slurred speech or problems with swallowing
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- sores, welting, or blisters
- stiff neck or back
- sudden numbness and weakness in the arms and legs
- swollen lymph glands
- tightness in the chest
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- yellow eyes and skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Body aches or pain
- ear congestion
- hard lump, redness, soreness, or swelling at the injection site
- loss of voice
- nasal congestion
- runny nose
- Abdominal or stomach pain
- bruising at the injection site
- dry mouth
- fainting or lightheadedness when getting up suddenly from a lying or sitting position
- feeling of constant movement of self or surroundings
- feeling of warmth
- headache, severe and throbbing
- large, flat, blue or purplish patches in the skin at the injection site
- loss of appetite
- muscle pain or stiffness
- pain, swelling, or redness in the joints
- redness of the face, neck, arms, and occasionally, upper chest
- sensation of spinning
- sleepiness or unusual drowsiness
- small, red or purple spots on the skin
- trouble with sleeping
- unable to sleep
- unusually fast heartbeat
- unusually warm skin
- weight loss
Incidence not known
- Acid or sour stomach
- continuing ringing or buzzing or other unexplained noise in the ears
- disturbed color perception
- double vision
- hair loss or thinning of the hair
- halos around lights
- hearing loss
- night blindness
- overbright appearance of lights
- painful blisters on the trunk of the body
- stomach discomfort or upset
- tunnel vision
- weakness of the muscles in your face
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
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