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Generic Name: emtricitabine and tenofovir disoproxil fumarate (EM trye SYE ta been and ten OF oh vir)
Brand Names:Truvada
Medically reviewed by Sanjai Sinha, MD Last updated on Apr 14, 2019.
What is Truvada?
Truvada contains a combination of emtricitabine and tenofovir disoproxil fumarate. Emtricitabine and tenofovir disoproxil fumarate are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body.
Emtricitabine and tenofovir is to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS, but it can be used to treat HIV in adults and children who are at least 12 years old and weigh at least 17 kilograms (37 pounds).
Truvada is also used in children who weigh between 55 and 77 pounds (25 to 35 kilograms) and who take certain other HIV medications.
Truvada PrEP is used together with safer-sex practices to reduce the risk of becoming infected with HIV. You must be HIV-negative and an adult to use Truvada PrEP for this purpose.
Important Information
Do not take Truvada if you also take other medicines that contain emtricitabine, tenofovir, lamivudine, or adefovir.
Truvada PrEP is used to reduce the risk of becoming infected with HIV in adults who are HIV-negative. This medicine alone will not protect you from infection with HIV. You must also use safer sex practices and get tested for HIV at least every 3 months.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.
If you’ve ever had hepatitis B, it may become active or get worse after you stop using Truvada. You may need frequent liver function tests for several months.
Before taking this medicine
You should not take Truvada if you are allergic to emtricitabine or tenofovir disoproxil fumarate. Do not take if you also use other medicines that contain emtricitabine, tenofovir, lamivudine, or adefovir (such as Atripla, Combivir, Complera, Descovy, Dutrebis, Emtriva, Epivir, Epzicom, Genvoya, Hepsera, Odefsey, Stribild, Triumeq, Trizivir, or Viread).
If you take Truvada PrEP to reduce your risk of HIV infection: You must have a negative HIV test immediately before you start taking the medicine.
Do not take Truvada PrEP to reduce infection risk if you are HIV-positive, if have been exposed to HIV within the past month, or if you had any symptoms (such as fever, sore throat, night sweats, swollen glands, diarrhea, body aches).
To make sure Truvada is safe for you, tell your doctor if you have ever had:
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liver disease (you may be tested for hepatitis B before you can use this medicine);
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osteopenia (low bone mineral density); or
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kidney disease.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you’ve taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.
Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
You should not breast-feed while you are using Truvada to treat or prevent HIV. Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
It is not known if Truvada is safe and effective in children with HIV-1 infection who weigh less than 37 pounds (less than 17 kilograms).
The dosing schedule for Truvada for the treatment of HIV-1 Infection in pediatric patients weighing 37 pounds (17) kg to less than 77 pounds (35) kg is as follows:
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Body weight 37 lb (17 kg) to less than 48 lb (22 kg) – one 100 mg/150 mg tablet once daily
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Body weight 48 lb (22 kg) to less than 62 lb (28 kg) – one 133 mg/200 mg tablet once daily
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Body weight 62 lb (28 kg) to less than 77 ln (35 kg) – one 167 mg/250 mg tablet once daily.
How should I take Truvada?
Take Truvada exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
You may take Truvada with or without food.
Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor’s advice. Every person with HIV should remain under the care of a doctor.
You will need frequent medical tests to check your kidney and liver function, or your bone mineral density.
Truvada PrEP alone will not protect you from infection with HIV. You must also use safer sex practices and get tested for HIV at least every 3 months.
Store in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use.
If you’ve ever had hepatitis B, this virus may become active or get worse in the months after you stop using Truvada. You may need frequent liver function tests while using this medicine and for several months after your last dose.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skipping doses may increase the risk of your virus becoming resistant to antiviral medicine. Try not to miss any doses.
Get your prescription refilled before you run out of medicine completely.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while taking Truvada?
Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Truvada side effects
Get emergency medical help if you have signs of an allergic reaction to Truvada: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.
Call your doctor at once if you have:
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symptoms of new HIV infection – fever, night sweats, tiredness, muscle or joint pain, sore throat, vomiting, diarrhea, rash, swollen glands in your neck or groin;
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sudden or unusual bone pain;
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kidney problems – little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or
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liver problems – nausea, swelling around your midsection, upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Emtricitabine and tenofovir disoproxil fumarate affects your immune system, which may cause certain side effects (even weeks or months after you’ve taken Truvada). Tell your doctor if you have:
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signs of a new infection – fever, sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
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trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
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swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.
Common Truvada side effects may include:
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headache, dizziness, feeling depressed or tired;
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trouble sleeping, strange dreams;
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nausea, stomach pain;
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weight loss; or
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rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Truvada?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Truvada can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Tylenol, Advil, and Aleve).
Other drugs may interact with emtricitabine and tenofovir disoproxil fumarate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Truvada only for the indication prescribed.
Copyright 1996-2020 Cerner Multum, Inc. Version: 13.01.
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Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Truvada and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/truvada.html
