Thuốc Triple Therapy (Oral)

29/03/2020

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Holevn Health share articles about :Thuốc Triple Therapy (Oral) , side effects – dosage , Thuốc Triple Therapy (Oral) what disease treatment.Other noted issues. Please refer to the details below.

Generic Name: lansoprazole, amoxicillin, and clarithromycin (Oral route)

lan-SOE-pra-zole, a-mox-i-SIL-in, kla-rith-roe-MYE-sin

Medically reviewed by Holevn.org. Last updated on Jul 22, 2019.

Commonly used brand name(s)

In the U.S.

Prevpac
Triple Therapy

Available Dosage Forms:

Capsule
Tablet
Capsule, Delayed Release

Uses for Triple Therapy

Prevpac® is a product containing three components: lansoprazole, amoxicillin, and clarithromycin. This medicine is used to treat patients with H. pylori infection and duodenal ulcers caused by H. pylori bacteria.

Lansoprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach. Amoxicillin and clarithromycin both belong to the class of medicines known as antibiotics. They work by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor’s prescription.

Before using Triple Therapy

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Prevpac® in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Prevpac® in the elderly. However, elderly patients are more likely to have kidney or liver problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Pregnancy

Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Alfuzosin
Amisulpride
Astemizole
Bepridil
Cisapride
Colchicine
Conivaptan
Dihydroergotamine
Dronedarone
Eletriptan
Eliglustat
Eplerenone
Ergoloid Mesylates
Ergonovine
Ergotamine
Flibanserin
Fluconazole
Isavuconazonium Sulfate
Ivabradine
Ketoconazole
Lomitapide
Lovastatin
Lurasidone
Maraviroc
Mesoridazine
Methylergonovine
Methysergide
Naloxegol
Nelfinavir
Nimodipine
Pimozide
Piperaquine
Posaconazole
Ranolazine
Rilpivirine
Saquinavir
Silodosin
Simvastatin
Sparfloxacin
Terfenadine
Thioridazine
Tolvaptan
Venetoclax
Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acalabrutinib
Ado-Trastuzumab Emtansine
Afatinib
Ajmaline
Alfentanil
Alprazolam
Amiodarone
Amitriptyline
Amlodipine
Amobarbital
Amphetamine
Amprenavir
Anagrelide
Apalutamide
Apomorphine
Aprepitant
Aprindine
Aprobarbital
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Artemether
Asenapine
Atazanavir
Atorvastatin
Avanafil
Axitinib
Azithromycin
Bedaquiline
Benzhydrocodone
Benzphetamine
Betrixaban
Bosutinib
Bretylium
Brexpiprazole
Brigatinib
Bromocriptine
Buprenorphine
Buserelin
Butabarbital
Butalbital
Cabazitaxel
Cabozantinib
Calcifediol
Capecitabine
Carbamazepine
Cariprazine
Ceritinib
Chloroquine
Chlorpromazine
Chlortetracycline
Cholera Vaccine, Live
Cilostazol
Ciprofloxacin
Citalopram
Clofazimine
Clomipramine
Clonazepam
Clopidogrel
Clozapine
Cobicistat
Cobimetinib
Codeine
Copanlisib
Crizotinib
Cyclobenzaprine
Dabigatran Etexilate
Dabrafenib
Daclatasvir
Dacomitinib
Dasatinib
Deflazacort
Degarelix
Delamanid
Delavirdine
Demeclocycline
Desipramine
Deslorelin
Deutetrabenazine
Dexamethasone
Dextroamphetamine
Digoxin
Dihydrocodeine
Diltiazem
Disopyramide
Docetaxel
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Doxorubicin
Doxorubicin Hydrochloride Liposome
Doxycycline
Droperidol
Dutasteride
Duvelisib
Ebastine
Edoxaban
Efavirenz
Elagolix
Elexacaftor
Encorafenib
Entrectinib
Enzalutamide
Eribulin
Erlotinib
Erythromycin
Escitalopram
Eslicarbazepine Acetate
Estazolam
Eszopiclone
Etravirine
Everolimus
Famotidine
Fedratinib
Felbamate
Felodipine
Fentanyl
Fingolimod
Flecainide
Fluoxetine
Fluticasone
Fosaprepitant
Foscarnet
Fosnetupitant
Fosphenytoin
Galantamine
Gatifloxacin
Gefitinib
Gemifloxacin
Glasdegib
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Halothane
Histrelin
Hydrocodone
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibrutinib
Ibutilide
Idelalisib
Ifosfamide
Iloperidone
Imipramine
Inotuzumab Ozogamicin
Irinotecan
Irinotecan Liposome
Isoflurane
Isradipine
Istradefylline
Itraconazole
Ivacaftor
Ivosidenib
Ixabepilone
Ketoconazole
Lapatinib
Larotrectinib
Ledipasvir
Lefamulin
Lenvatinib
Letrozole
Leuprolide
Levofloxacin
Levomilnacipran
Lisdexamfetamine
Lofexidine
Lopinavir
Lorcainide
Lorlatinib
Losartan
Lumacaftor
Lumefantrine
Lymecycline
Macimorelin
Macitentan
Manidipine
Meclocycline
Mefloquine
Meperidine
Mephobarbital
Methacycline
Methadone
Methamphetamine
Methohexital
Methotrexate
Metronidazole
Midazolam
Midostaurin
Mifepristone
Minocycline
Mizolastine
Modafinil
Morphine
Morphine Sulfate Liposome
Moxifloxacin
Mycophenolate Mofetil
Nafarelin
Nafcillin
Nelfinavir
Neratinib
Netupitant
Nicardipine
Nifedipine
Nilotinib
Nisoldipine
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Olanzapine
Olaparib
Ondansetron
Osimertinib
Ospemifene
Oxcarbazepine
Oxycodone
Oxytetracycline
Palbociclib
Paliperidone
Panobinostat
Paroxetine
Pasireotide
Pazopanib
Pentamidine
Pentazocine
Pentobarbital
Perampanel
Perphenazine
Pexidartinib
Phenobarbital
Phenytoin
Pimavanserin
Pipamperone
Pirmenol
Pitolisant
Pixantrone
Ponatinib
Probucol
Procainamide
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinidine
Quinine
Reboxetine
Regorafenib
Retapamulin
Ribociclib
Rifabutin
Rifapentine
Riociguat
Risperidone
Ritonavir
Rivaroxaban
Roflumilast
Rolitetracycline
Romidepsin
Ruxolitinib
Salmeterol
Saquinavir
Sarecycline
Secobarbital
Secretin Human
Sertindole
Sertraline
Sevoflurane
Sildenafil
Simeprevir
Siponimod
Sirolimus
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sonidegib
Sorafenib
Sotalol
Spiramycin
St John’s Wort
Sufentanil
Sulfamethoxazole
Sulfasalazine
Sulpiride
Sunitinib
Suvorexant
Tacrolimus
Tadalafil
Talazoparib
Tamoxifen
Tamsulosin
Telaprevir
Telavancin
Telithromycin
Temsirolimus
Tetrabenazine
Tetracycline
Tezacaftor
Thiopental
Thiotepa
Ticagrelor
Tizanidine
Tolterodine
Topotecan
Toremifene
Trabectedin
Tramadol
Trazodone
Triazolam
Triclabendazole
Trimethoprim
Trimipramine
Triptorelin
Valbenazine
Vandetanib
Vardenafil
Velpatasvir
Vemurafenib
Venlafaxine
Verapamil
Vilanterol
Vilazodone
Vinblastine
Vincristine
Vincristine Sulfate Liposome
Vinflunine
Vinorelbine
Vismodegib
Vorapaxar
Voriconazole
Vorinostat
Voxelotor
Warfarin
Zaleplon
Zanubrutinib
Zidovudine
Zileuton
Zolpidem
Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol
Cyclosporine
Darunavir
Delavirdine
Diazepam
Dicumarol
Glipizide
Glyburide
Hexobarbital
Indinavir
Khat
Levothyroxine
Linezolid
Methylprednisolone
Nevirapine
Phenprocoumon
Pravastatin
Prednisone
Probenecid
Repaglinide
Rifampin
Tacrolimus
Tipranavir
Warfarin

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Cranberry
food

Proper use of Triple Therapy

This section provides information on the proper use of a number of products that contain lansoprazole, amoxicillin, and clarithromycin. It may not be specific to Triple Therapy. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Prevpac® comes with an individual daily administration card that contains: 2 pink and black capsules of lansoprazole, 4 opaque, yellow capsules of amoxicillin, and 2 yellow tablets of clarithromycin.

Swallow the capsules and tablet whole. Do not crush, break, chew, or open any of them. Take each dose on an empty stomach, before a meal.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (kit):
- For treatment of duodenal ulcers and H. pylori infections:
  - Adults—30 milligrams (mg) or 1 capsule of lansoprazole, 1000 mg or 2 capsules of amoxicillin, and 500 mg or 1 tablet of clarithromycin taken together two times per day (morning and evening) for 10 or 14 days.
  - Children—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using Triple Therapy

It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, talk with your doctor.

Do not use this medicine if you are also using astemizole (Hismanal®), atazanavir (Reyataz®), cisapride (Propulsid®), lovastatin (Mevacor®), pimozide (Orap®), simvastatin (Zocor®), terfenadine (Seldane®), certain ergot medicines (such as dihydroergotamine, ergotamine, D.H.E. 45®, Ergomar®, Ergostat®, or Migranal®), or medicines containing rilpivirine. If you have kidney or liver disease, do not take this medicine together with colchicine (Colcrys®). Using these medicines together may increase risk for more serious side effects.

This medicine may cause serious allergic reactions, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, fever or chills, hoarseness, sores or ulcers on the skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine.

Make sure your doctor knows if you are pregnant or planning to become pregnant. If you become pregnant while using this medicine, tell your doctor right away.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Check with your doctor right away if you have a fever, joint pain, skin rash, swelling of the body, feet, or ankles, or unusual weight gain after receiving this medicine. These could be symptoms of serious kidney problem called acute interstitial nephritis.

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John’s wort) or vitamin supplements.

Triple Therapy side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Blistering, peeling, or loosening of the skin
chills
clay colored stools
dark urine
diarrhea
difficulty with swallowing
dizziness or fainting
fast, slow, or irregular heartbeat
fever
headache
hives, itching, or skin rash
joint or muscle pain
loss of appetite
nausea
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red skin lesions, often with a purple center
red, irritated eyes
sores, ulcers, or white spots in the mouth or on the lips
stomach pain or tenderness
swelling of the body, feet, and ankles
tightness in the chest
unusual tiredness or weakness
unusual weight gain
vomiting
watery and severe diarrhea, which may also be bloody
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bad, unusual or unpleasant (after) taste
change in taste

Less common

Confusion
discoloration of the tongue
itching of the vagina or genital area
pain during sexual intercourse
redness, swelling, or soreness of the tongue
sore mouth or tongue
thick, white vaginal discharge with no odor or with a mild odor
white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

Medical Disclaimer

The content of Holevn is solely for the purpose of providing information about Thuốc Triple Therapy (Oral) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/triple-therapy.html

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