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Generic Name: vortioxetine (VOR tye OX e teen)
May 2, 2016 – Takeda Pharmaceuticals U.S.A., Inc. and Lundbeck announced that Brintellix (vortioxetine) will be marketed in the United States under the new name Trintellix (vortioxetine) effective June 2016. The change comes after receiving reports of name confusion in the marketplace between Brintellix and the anti-blood clotting therapy Brilinta (ticagrelor). The formulation, indication, dosage forms and strengths of Trintellix remain the same as Brintellix.
Medically reviewed by J. Stewart, BPharm Last updated on Sep 4, 2019.
What is Trintellix?
Trintellix (vortioxetine) is a precription medicine that affects chemicals in the brain that may be unbalanced.
Trintellix is an antidepressant that is used to treat major depressive disorder in adults.
Trintellix may also be used for purposes not listed in this medication guide.
Do not use Trintellix if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. After you stop taking Trintellix you must wait at least 21 days before you start taking an MAO inhibitor.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Do not give Trintellix to anyone younger than 18 years old without the advice of a doctor. This medicine is not approved for use in children.
Before taking this medicine
You should not use Trintellix if you are allergic to vortioxetine.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
After you stop taking Trintellix you must wait at least 21 days before you start taking an MAO inhibitor.
Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with vortioxetine and cause a serious condition called serotonin syndrome.
Trintellix is not approved for use by anyone younger than 18 years old.
To make sure this medicine is safe for you, tell your doctor if you have:
bipolar disorder (manic depression), or a history of drug abuse or suicidal thoughts;
seizures or epilepsy;
bleeding or blood clotting disorder; or
low levels of sodium in your blood.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Taking Trintellix in the last 3 months of pregnancy may cause problems in the newborn, such as life-threatening withdrawal symptoms, serious lung problems or other complications in the baby. Tell your doctor if you are pregnant.
Do not start or stop taking Trintellix during pregnancy without your doctor’s advice. Vortioxetine may harm an unborn baby, but you may have a relapse of major depressive disorder or other problems if you stop taking this medicine during pregnancy. The benefit of continuing treatment with this medicine may outweigh any risks to the baby.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How should I take Trintellix?
Take Trintellix exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
You may take Trintellix with or without food.
Do not stop using Trintellix suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture and heat.
Trintellix dosing information
Usual Adult Dose for Depression:
Initial dose: 10 mg orally once a day
Maintenance dose: 5 to 20 mg orally once a day
Maximum dose: 20 mg/day
-Efficacy was established in trials lasting 6 to 8 weeks.
-Treatment of acute episodes should be followed by maintenance therapy lasting at least several months to decrease the risk of recurrence.
Use: Treatment of major depressive disorder (MDD)
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while taking Trintellix?
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Trintellix side effects
Get emergency medical help if you have signs of an allergic reaction to Trintellix: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
racing thoughts, decreased need for sleep, unusual risk-taking behavior, feelings of extreme happiness or sadness, being more talkative than usual;
vision changes, eye pain, eye redness or swelling;
easy bruising, unusual bleeding, coughing up blood; or
low sodium level (may be more likely to occur in older adults – confusion, memory problems, hallucinations, slurred speech, severe weakness, feeling unsteady.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common Trintellix side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Trintellix?
Tell your doctor about all your current medicines. Many drugs can interact with vortioxetine, especially:
medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;
any other antidepressant;
a blood thinner (warfarin, Coumadin, Jantoven);
a diuretic or “water pill”;
St. John’s wort, tryptophan (sometimes called L-tryptophan);
migraine headache medicine (triptan);
NSAIDs (nonsteroidal anti-inflammatory drugs) – aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or
seizure medicine – carbamazepine, phenytoin.
This list is not complete and many other drugs may affect vortioxetine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trintellix only for the indication prescribed.
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The content of Holevn is solely for the purpose of providing information about Thuốc Trintellix and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/trintellix.html