Holevn Health share articles about :Thuốc Trexall , side effects – dosage , Thuốc Trexall what disease treatment.Other noted issues. Please refer to the details below.
Generic Name: methotrexate (oral) (meth oh TREX ate)
Brand Name:Trexall, Xatmep
Medically reviewed by Holevn.org on Dec 20, 2019 – Written by Cerner Multum
What is Trexall?
Trexall is used to treat certain types of cancer of the breast, skin, head and neck, or lung. This medicine is also used to treat severe psoriasis and rheumatoid arthritis.
Trexall is usually given after other treatments have failed.
Trexall may also be used for purposes not listed in this medication guide.
YOU MAY NOT NEED TO TAKE Trexall EVERY DAY. Some people have died after incorrectly taking this medicine every day. You must use the correct dose for your condition.
Do not use Trexall to treat psoriasis or rheumatoid arthritis if you have low blood cell counts, a bone marrow disorder, liver disease (especially if caused by alcoholism), or if you are pregnant or breast-feeding.
Trexall can cause serious or life-threatening side effects. Call your doctor if you have diarrhea, mouth sores, cough, shortness of breath, upper stomach pain, dark urine, numbness or tingling, muscle weakness, confusion, seizure, or skin rash that spreads and causes blistering and peeling.
Before taking this medicine
You should not use Trexall if you are allergic to it. You may not be able to take this medicine if you have:
alcoholism, cirrhosis, or chronic liver disease;
low blood cell counts;
a weak immune system or bone marrow disorder; or
if you are pregnant or breastfeeding.
Trexall is sometimes used even when patients do have one of the conditions listed above. Your doctor will decide if Trexall is right for you.
Tell your doctor if you have ever had:
liver problems, especially fluid in your stomach (ascites);
lung problems, especially fluid in the lungs (pleural effusion);
radiation treatments; or
a stomach ulcer or ulcerative colitis.
Trexall can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.
If you are a woman, do not use Trexall to treat psoriasis or rheumatoid arthritis if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use an effective form of birth control while you are taking this medicine, and for 6 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Trexall.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Trexall can harm an unborn baby.
Do not breastfeed while using this medicine.
Do not give this medicine to a child without the advice of a doctor.
How should I take Trexall?
YOU MAY NOT NEED TO TAKE Trexall EVERY DAY. This medicine is sometimes taken only 1 or 2 times per week, or once every 12 hours for only 3 doses. Some conditions are treated daily for just a few days followed by a rest period of 1 week or longer before taking the medicine again.
You must use the correct dose. Some people have died after incorrectly taking Trexall every day.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Ask your doctor or pharmacist if you have questions about how often to take Trexall.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Trexall can be toxic to your organs, and may lower your blood cell counts. You will need frequent medical tests, and your next dose may be delayed based on the results.
If you need to be sedated for dental work, tell your dentist you currently use Trexall.
Store tablets at room temperature away from moisture, heat, and light.
Store the liquid medicine in the refrigerator, do not freeze.
You may also store the liquid at room temperature for up to 60 days.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of Trexall.
What happens if I overdose?
Seek emergency medical attention or call 115. An overdose of methotrexate can be fatal.
Overdose symptoms may include bruising or unusual bleeding, mouth sores, vomiting, little or no urination, bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
What should I avoid while taking Trexall?
Avoid drinking alcohol. It may increase your risk of liver damage.
Do not receive a “live” vaccine while using Trexall, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Trexall could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Trexall can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient’s body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Trexall side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
severe ongoing vomiting or diarrhea;
dry cough, chest pain, shortness of breath or rapid breathing;
kidney problems–little or no urination, swelling in your feet or ankles;
liver problems–stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes);
low blood cell counts–fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
nerve problems–weakness, coordination problems, loss of movement in any part of your body;
signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
signs of tumor cell breakdown–confusion, weakness, muscle cramps, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.
Common side effects may include:
low blood cell counts, infections (fever, chills, tiredness, bruising, not feeling well);
nausea, upset stomach, vomiting, diarrhea;
hair loss; or
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Trexall?
Trexall can harm your liver, especially if you also use certain medicines for infections, tuberculosis, depression, birth control, hormone replacement, high cholesterol, heart problems, high blood pressure, seizures, pain, or arthritis (including Tylenol, Advil, Motrin, or Aleve).
Many drugs can affect Trexall. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 15.01.
The content of Holevn is solely for the purpose of providing information about Thuốc Trexall and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/trexall.html