Thuốc Trastuzumab and hyaluronidase-oysk (Subcutaneous)

Thuốc Trastuzumab and hyaluronidase-oysk (Subcutaneous)
Thuốc Trastuzumab and hyaluronidase-oysk (Subcutaneous)

Holevn Health share articles about :Thuốc Trastuzumab and hyaluronidase-oysk (Subcutaneous)  , side effects – dosage , Thuốc Trastuzumab and hyaluronidase-oysk (Subcutaneous) what disease treatment.Other noted issues. Please refer to the details below.

tras-TOOZ-oo-mab, hye-al-ure-ON-i-dase – oysk

Subcutaneous route(Solution)

Cardiomyopathy: Trastuzumab/hyaluronidase-oysk can result in subclinical and clinical cardiac failure manifesting as congestive heart failure, and decreased left ventricular ejection fraction, with greatest risk when administered concurrently with anthracyclines. Evaluate cardiac function prior to and during treatment. Discontinue trastuzumab/hyaluronidase-oysk for cardiomyopathy.Pulmonary Toxicity: Discontinue trastuzumab/hyaluronidase-oysk for anaphylaxis, angioedema, interstitial pneumonitis or acute respiratory distress syndrome.Embryo-Fetal Toxicity: Exposure to trastuzumab/hyaluronidase-oysk during pregnancy can result in oligohydramnios, in some cases complicated by pulmonary hypoplasia and neonatal death. Advise patients of these risks and the need for effective contraception .

Medically reviewed by Last updated on Apr 12, 2019.

Commonly used brand name(s)

In the U.S.

  • Herceptin Hylecta

Available Dosage Forms:

  • Solution

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Monoclonal Antibody

Uses for trastuzumab and hyaluronidase-oysk

Trastuzumab and hyaluronidase-oysk combination injection is used together with other cancer medicines (eg, doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel, docetaxel and carboplatin, or after anthracycline medicine) to treat HER2-overexpressing node-positive or node-negative (ER/PR negative or with one high risk feature) breast cancer.

Trastuzumab and hyaluronidase-oysk combination injection is also used together with paclitaxel for the first-line treatment of HER2-overexpressing metastatic (cancer that has spread) breast cancer. It is also used to treat HER2-overexpressing metastatic breast cancer in patients who have received one or more chemotherapy treatments.

Trastuzumab and hyaluronidase-oysk combination prevents the growth of some tumors that produce extra amounts of a certain substance known as the HER2 protein. It should only be used in patients whose tumors have been shown to produce extra amounts of this protein (HER2 overexpression).

Trastuzumab and hyaluronidase-oysk is to be given only by or under the direct supervision of your doctor.

Before using trastuzumab and hyaluronidase-oysk

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trastuzumab and hyaluronidase-oysk, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to trastuzumab and hyaluronidase-oysk or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of trastuzumab and hyaluronidase-oysk combination injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of trastuzumab and hyaluronidase-oysk combination injection in the elderly. However, elderly patients are more likely to have age-related heart problems, which may require caution in patients receiving trastuzumab and hyaluronidase-oysk.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving trastuzumab and hyaluronidase-oysk, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using trastuzumab and hyaluronidase-oysk with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aclarubicin
  • Amrubicin
  • Daunorubicin
  • Daunorubicin Citrate Liposome
  • Daunorubicin Liposome
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Epirubicin
  • Idarubicin
  • Pirarubicin
  • Pixantrone
  • Tofacitinib
  • Valrubicin

Using trastuzumab and hyaluronidase-oysk with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Warfarin

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of trastuzumab and hyaluronidase-oysk. Make sure you tell your doctor if you have any other medical problems, especially:

  • Congestive heart failure or
  • Heart disease (eg, cardiomyopathy) or
  • Heart rhythm problems (eg, arrhythmia) or
  • Hypertension (high blood pressure) or
  • Lung disease (eg, interstitial pneumonitis, pulmonary fibrosis, tumor)—Use with caution. May make these conditions worse.

Proper use of trastuzumab and hyaluronidase-oysk

Medicines used to treat cancer are very strong and can have many side effects. Before receiving trastuzumab and hyaluronidase-oysk, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

A doctor or other trained health professional will give you trastuzumab and hyaluronidase-oysk in a medical facility. It is given as a shot under your skin for at least 2 to 5 minutes once every 3 weeks.

If you miss a dose of trastuzumab and hyaluronidase-oysk, you must receive a dose as soon as possible. The doses should not be less than three weeks from each other.

Precautions while using trastuzumab and hyaluronidase-oysk

It is very important that your doctor check your progress at regular visits to make sure that trastuzumab and hyaluronidase-oysk is working properly. Blood tests may be needed to check for unwanted effects.

Receiving trastuzumab and hyaluronidase-oysk while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with trastuzumab and hyaluronidase-oysk and for 7 months after the last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

Your doctor may test your heart before you start receiving trastuzumab and hyaluronidase-oysk combination injection and while you are getting treatments with trastuzumab and hyaluronidase-oysk. Contact your doctor right away if you experience any chest pain, increased coughing, trouble with breathing, a sudden difficulty with breathing at night, rapid weight gain, or abnormal swelling in your ankles or legs. These could be symptoms of a serious heart problem.

Serious lung or breathing problems may occur after you receive trastuzumab and hyaluronidase-oysk. Call your doctor right away if have changes in your breathing, chest tightness, or any type of breathing problem.

Trastuzumab and hyaluronidase-oysk can temporarily lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

Trastuzumab and hyaluronidase-oysk may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving trastuzumab and hyaluronidase-oysk.

Do not receive an anthracycline medicine for up to 7 months after stopping treatment with trastuzumab and hyaluronidase-oysk.

Trastuzumab and hyaluronidase-oysk side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Black, tarry stools
  • blurred vision
  • body aches or pain
  • chest pain or tightness
  • chills
  • cough
  • decreased urine output
  • diarrhea
  • difficulty in breathing
  • dilated neck veins
  • dizziness
  • ear congestion
  • extreme tiredness or weakness
  • fast heartbeat
  • fever
  • general feeling of discomfort or illness
  • headache
  • hives, itching, skin rash
  • hoarseness
  • irregular breathing
  • irritation
  • joint pain, stiffness, or swelling
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • nervousness
  • nosebleed
  • painful or difficult urination
  • pale skin
  • pounding in the ears
  • redness of the skin
  • runny nose or stuffy nose
  • shivering
  • slow, fast, or irregular heartbeat
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • swollen glands
  • trouble sleeping
  • troubled swallowing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Less common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate

Incidence not known

  • Bleeding gums
  • bluish color of the fingernails, lips, skin, palms, or nail beds
  • confusion
  • increased thirst
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • pinpoint red spots on the skin
  • seizures
  • stomach cramps or pain
  • tremor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Arm, back, or leg pain
  • belching
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • bone pain
  • burning, numbness, tingling, or painful sensations
  • difficulty in moving
  • discoloration of fingernails or toenails
  • feeling of warmth
  • hair loss or thinning of hair
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss or change in taste
  • muscle stiffness
  • redness of the face, neck, arms and occasionally, upper chest
  • skin discoloration
  • stomach discomfort or upset
  • swelling or inflammation of the mouth
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

Less common

  • Nasal discomfort

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Trastuzumab and hyaluronidase-oysk (Subcutaneous)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

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