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Generic Name: dolutegravir (DOE loo TEG ra vir)
Medically reviewed by P. Thornton, DipPharm Last updated on Dec 11, 2018.
What is Tivicay?
Tivicay (dolutegravir) is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.
Tivicay is used with other antiviral medications to treat HIV, the virus that can cause the acquired immunodeficiency syndrome (AIDS).
Tivicay is not a cure for HIV or AIDS.
Tivicay is for use in adults and children who weigh at least 66 pounds (30 kilograms).
You should not use Tivicay if you are also taking dofetilide (Tikosyn).
Taking Tivicay during the first trimester of pregnancy may cause birth defects. Use effective birth control to prevent pregnancy while you are using dolutegravir.
Before taking this medicine
You should not use Tivicay if you are allergic to dolutegravir, or if you are also taking dofetilide (Tikosyn).
Tell your doctor if you have ever had:
liver disease, especially hepatitis B or C.
You may need to have a negative pregnancy test before starting treatment with Tivicay.
Tivicay may harm an unborn baby if you take the medicine at the time of conception or during the first 12 weeks of pregnancy. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of dolutegravir on the baby.
Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
How should I take Tivicay?
Take Tivicay exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
You may take Tivicay with or without food.
Dolutegravir doses are based on weight in children. Your child’s dose needs may change if the child gains or loses weight.
While using Tivicay, you may need frequent blood tests.
If you’ve ever had hepatitis B, using dolutegravir can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.
Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor’s advice. Every person with HIV should remain under the care of a doctor.
Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with any packet or canister of moisture-absorbing preservative.
Tivicay dosing information
Usual Adult Dose for HIV Infection:
Therapy-naive or therapy-experienced integrase strand transfer inhibitor (INSTI)-naive patients or virologically-suppressed patients switching to this drug plus rilpivirine: 50 mg orally once a day
Therapy-naive or therapy-experienced INSTI-naive patients when coadministered with certain UGT1A or CYP450 3A inducers: 50 mg orally twice a day
INSTI-experienced patients with certain INSTI-associated resistance substitutions or clinically suspected INSTI resistance: 50 mg orally twice a day
-Rilpivirine dose is 25 mg orally once a day for patients switching to this drug plus rilpivirine.
-The manufacturer product information should be consulted for relevant UGT1A or CYP450 3A inducers.
-In INSTI-experienced patients, alternative combinations that do not include metabolic inducers should be considered where possible.
-In combination with other antiretroviral agents, for the treatment of HIV-1 infection
-In combination with rilpivirine, as a complete regimen for the treatment of HIV-1 infection to replace a stable antiretroviral regimen in patients who are virologically-suppressed (HIV-1 RNA less than 50 copies/mL) for at least 6 months with no history of treatment failure and no known substitutions associated with resistance to either drug
Usual Pediatric Dose for HIV Infection:
30 to less than 40 kg: 35 mg orally once a day
At least 40 kg: 50 mg orally once a day
-Recommended for therapy-naive or therapy-experienced INSTI-naive patients
-If certain UGT1A or CYP450 3A inducers are coadministered, the weight-based dose should be increased to twice a day; the manufacturer product information should be consulted for relevant inducers.
-Safety and efficacy not established in INSTI-experienced patients with documented or clinically suspected resistance to other INSTIs (raltegravir, elvitegravir).
Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while taking Tivicay?
Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Tivicay side effects
Stop taking this medicine and get emergency medical help if you have signs of an allergic reaction ro Tivicay: fever, general ill feeling, trouble breathing, extreme tiredness; mouth sores, redness or swelling in your eyes; blistering or peeling skin; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
the first sign of any skin rash, no matter how mild; or
liver problems – nausea, vomiting, loss of appetite, upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Dolutegravir affects your immune system, which may cause certain side effects (even weeks or months after you’ve taken this medicine). Tell your doctor if you have:
signs of a new infection – fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.
Common Tivicay side effects may include:
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Tivicay?
Some medicines can make dolutegravir much less effective when taken at the same time. If you take any of the following medicines, take your Tivicay dose 2 hours before or 6 hours after you take the other medicine.
antacids or laxatives that contain calcium, magnesium, or aluminum (such as Amphojel, Di-Gel Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Rulox, Tums, and others), or the ulcer medicine sucralfate (Carafate);
vitamin or mineral supplements that contain calcium or iron (but if you take Tivicay with food, you can take these supplements at the same time).
Tell your doctor about all your other medicines, especially:
oral diabetes medication that contains metformin;
tuberculosis medication that contains rifampin;
St. John’s wort;
other HIV or AIDS medicines – efavirenz, etravirine, fosamprenavir/ritonavir, nevirapine, tipranavir/ritonavir; or
seizure medication – carbamazepine, oxcarbazepine, phenobarbital, phenytoin.
This list is not complete. Other drugs may interact with dolutegravir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tivicay only for the indication prescribed.
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The content of Holevn is solely for the purpose of providing information about Thuốc Tivicay and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/tivicay.html
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