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Intravenous route(Powder for Solution)
Patients with preexisting moderate/severe renal impairment (CrCl 50 mL/min or less) who were treated with telavancin for hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia had increased mortality observed versus vancomycin. Use of telavancin in patients with pre-existing moderate/severe renal impairment (CrCl 50 mL/min or less) should be considered only when the anticipated benefit to the patient outweighs the potential risk. Nephrotoxicity: New onset or worsening renal impairment has occurred. Monitor renal function in all patients. Women of childbearing potential should have a serum pregnancy test prior to administration of telavancin. Avoid use of telavancin during pregnancy unless the potential benefit to the patient outweighs the potential risk of the fetus. Adverse development outcomes observed in 3 animal species at clinically relevant doses raise concerns about potential adverse developmental outcomes in humans .
Medically reviewed by Holevn.org. Last updated on Sep 12, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antibiotic
Chemical Class: Glycopeptide
Uses for telavancin
Telavancin injection is used alone or together with other medicines to treat serious bacterial skin infections, and hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP).
Telavancin belongs to the group of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, telavancin will not work for colds, flu, or other virus infections.
Telavancin is to be given only by or under the direct supervision of your doctor.
Before using telavancin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For telavancin, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to telavancin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of telavancin injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of telavancin injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving telavancin injection.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving telavancin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using telavancin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using telavancin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Cholera Vaccine, Live
- Inotuzumab Ozogamicin
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of telavancin. Make sure you tell your doctor if you have any other medical problems, especially:
- Congestive heart failure or
- Diabetes or
- Hypertension (high blood pressure)—Use of telavancin may lead to kidney problems.
- Heart rhythm problems (eg, QT prolongation), or a family history of—Use with caution. May make these conditions worse.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper use of telavancin
A nurse or other trained health professional will give you telavancin. Telavancin is given through a needle placed in one of your veins.
Telavancin comes with a Medication Guide. Read and follow the instructions in the guide carefully. Ask your doctor if you have any questions.
Precautions while using telavancin
It is very important that your doctor check your progress while you are receiving telavancin to make sure that it is working properly. Blood and urine tests may be needed to check for unwanted effects.
Using telavancin while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
You must have a negative pregnancy test before you will be given telavancin. If you miss a period while you are using telavancin, tell your doctor right away.
Do not use telavancin if you are also receiving unfractionated heparin sodium injection. Using these medicines together may cause serious unwanted effects.
Check with your doctor right away if you have blood in the urine, a change in the frequency of urination or amount of urine, difficulty with breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, or swelling of the feet or lower legs. These may be symptoms of a serious kidney problem.
Telavancin may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you get the injection.
Telavancin may cause a rare but serious type of infusion reaction called the “Red-man Syndrome.” Tell your doctor right away if you start to have itching, hives, chills or fever, a fast heartbeat, nausea or vomiting, a rash or redness of the face, base of the neck, upper body, back, and arms.
Telavancin injection may cause diarrhea, and in some cases, it can be severe. It may occur 2 months or more after you stop using telavancin. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
Before you have any medical tests, tell the medical doctor in charge that you are using telavancin. The results of some tests may be affected by telavancin.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Telavancin side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Blood in the urine
- change in the frequency of urination or amount of urine
- difficulty with breathing
- increased thirst
- loss of appetite
- nausea or vomiting
- swelling of the feet or lower legs
Incidence not known
- Abdominal or stomach tenderness
- chills or fever
- difficulty with swallowing
- dizziness, faintness, or lightheadedness, especially when getting up suddenly from a lying or sitting position
- fast heartbeat
- hives or itching of the skin
- nausea or vomiting
- pain, redness, or soreness at the injection site
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rash or redness of the face, base of the neck, upper body, back, and arms
- severe abdominal or stomach cramps and pain
- tightness in the chest
- unusual tiredness or weakness
- watery and severe diarrhea, which may also be bloody
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bad, unusual or unpleasant (after) taste
- change in taste
- foamy urine
- Decreased appetite
- dry, red, hot, or irritated skin
- feeling unusually cold
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
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Reference from: https://www.drugs.com/cons/telavancin-intravenous.html