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tee-boe – fil-GRA-stim
Medically reviewed by Holevn.org. Last updated on Apr 18, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Hematopoietic
Pharmacologic Class: Colony Stimulating Factor
Uses for tbo-filgrastim
Tbo-filgrastim injection is used to treat severe neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in the body called a colony stimulating factor. Tbo-filgrastim helps the bone marrow to make new white blood cells.
When certain cancer medicines are used to fight cancer cells, they also affect the white blood cells that fight infections. Tbo-filgrastim is used to prevent or reduce the risk of infection while you are being treated with cancer medicines.
Tbo-filgrastim is available only with your doctor’s prescription.
Before using tbo-filgrastim
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tbo-filgrastim, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to tbo-filgrastim or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of tbo-filgrastim injection in children younger than 1 month of age. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tbo-filgrastim injection in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of tbo-filgrastim. Make sure you tell your doctor if you have any other medical problems, especially:
- Glomerulonephritis (kidney disease) or
- Leukocytosis (high white blood cell count) or
- Lung disease or breathing problems or
- Sickle cell disease (red blood cell disease), history—Use with caution. May make these conditions worse.
Proper use of tbo-filgrastim
A nurse or other trained health professional will give you tbo-filgrastim. It is given as a shot under your skin (usually in the abdomen, front of the middle thighs, upper outer areas of the buttocks, or upper back portion of the upper arms).
You may be taught how to give tbo-filgrastim at home. Make sure you understand all of the instructions before giving yourself an injection. Use tbo-filgrastim only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.
Tbo-filgrastim comes with a patient information leaflet and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions about:
- How to prepare the injection.
- The proper use of disposable syringes.
- How to give the injection.
- How long the injection can be stored at home.
Tbo-filgrastim is available in two forms: a vial (glass container) or a prefilled syringe. These are the dosage forms that you can use at home.
Allow the medicine to warm to room temperature for 30 minutes before you inject it. If the liquid in the syringe or vial has changed color, looks cloudy, or if you see particles in it, do not use it. Do not shake the syringe or vial.
Each syringe or vial of medicine is good for only one dose. Throw the syringe or vial away after your dose. Do not save unused medicine from an opened syringe or vial.
You should not use tbo-filgrastim within 24 hours (1 day) before or after receiving cancer medicine or radiation treatments. Also do not use it within 24 hours before you begin another dose of chemotherapy.
The dose of tbo-filgrastim will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of tbo-filgrastim. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For injectable dosage form:
- For neutropenia:
- Adults and children 1 month of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 microgram per kilogram (mcg/kg) of body weight injected under the skin per day.
- Children younger than 1 month of age—Use and dose must be determined by your doctor.
- For neutropenia:
Tbo-filgrastim needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Store in the refrigerator. Do not freeze.
Keep tbo-filgrastim in its original container until you are ready to use it. You may store it at room temperature for up to 5 days, and if not used can be returned to the refrigerator. Throw away any unused medicine that has been left at room temperature for more than 5 days.
Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
Precautions while using tbo-filgrastim
It is very important that your doctor check your or your child’s progress at regular visits to make sure tbo-filgrastim is working properly. Blood and urine tests may be needed to check for unwanted effects.
Check with your doctor right away at the first sign of an infection, such as fever, chills, cough, sore throat, or unusual tiredness or weakness.
Check with your doctor right away if you or your child have pain in the upper left part of your stomach or at the tip of the left shoulder. These could be symptoms of a serious condition with the spleen.
Check with your doctor right away if you or your child have a fever, chest pain or tightness, or trouble breathing. These could be symptoms of a serious lung condition called acute respiratory distress syndrome (ARDS).
Tbo-filgrastim may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have a rash, itching skin, dizziness, lightheadedness, or fainting, swelling of the face, tongue, or throat, trouble breathing, or chest pain after using the medicine.
Tbo-filgrastim may cause kidney problems. Call your doctor right away if you or your child have swelling in your face or ankles, blood in the urine, or a decrease in how much or how often you urinate.
Tbo-filgrastim may cause a condition called capillary leak syndrome. It can cause fluid to leak from the blood vessels into your body’s tissues. Call your doctor right away if you or your child have swelling or puffiness, urinating less often, trouble breathing, feeling of fullness, dizziness, or feeling faint.
Tbo-filgrastim may cause aortitis (inflammation of the aorta, the largest artery in the body). Check with your doctor right away if you have fever, stomach pain, unusual tiredness or weakness, or back pain.
Make sure any doctor or dentist who treats you knows that you are using tbo-filgrastim. Tbo-filgrastim may affect the results of certain medical tests (eg, bone-imaging test).
Tbo-filgrastim side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- bone pain
- pinpoint red spots on the skin
- unusual bleeding or bruising
- eye pain
- general feeling of illness
- sore throat
- unusual tiredness
Incidence not known
- Blisters or fever sores on the skin
- bloody or cloudy urine
- chest pain or tightness
- difficulty with swallowing
- fast heartbeat
- hives, itching, or skin rash
- pain in the upper left part of the stomach or at the tip of the left shoulder
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- trouble breathing
- unusual weakness
- weight gain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- pain in the arms or legs
Incidence not known
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- lack or loss of strength
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
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Reference from: https://www.drugs.com/cons/tbo-filgrastim-subcutaneous.html