Holevn Health share articles about :Thuốc Talimogene laherparepvec (Injection) , side effects – dosage , Thuốc Talimogene laherparepvec (Injection) what disease treatment.Other noted issues. Please refer to the details below.
Medically reviewed by Holevn.org. Last updated on Apr 25, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antineoplastic Agent
Uses for talimogene laherparepvec
Talimogene laherparepvec injection is used to treat melanoma (skin cancer) when it is on your skin or in your lymph glands. Talimogene laherparepvec is a weakened form of Herpes Simplex Virus Type 1 (cold sore virus).
Talimogene laherparepvec is given only by or under the direct supervision of your doctor.
Before using talimogene laherparepvec
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For talimogene laherparepvec, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to talimogene laherparepvec or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of talimogene laherparepvec injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of talimogene laherparepvec injection in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of talimogene laherparepvec. Make sure you tell your doctor if you have any other medical problems, especially:
- Autoimmune disease or
- Glomerulonephritis (kidney problem) or
- Pneumonitis (inflammation of the lung tissue) or
- Psoriasis (skin problem) or
- Vasculitis (inflammation of the blood vessels) or
- Vitiligo (skin problem)—Use with caution. May make these conditions worse.
- Leukemia, history of or
- Lymphoma, history of or
- Weak immune system (including AIDS or HIV infection), history of—Should not be used in patients with these conditions.
- Multiple myeloma—May increase risk for more serious side effects.
Proper use of talimogene laherparepvec
A doctor or other trained health professional will give you talimogene laherparepvec in a hospital or cancer treatment center. Talimogene laherparepvec is injected directly into your tumor(s).
You will receive talimogene laherparepvec again 3 weeks after your first treatment. After that, you will receive talimogene laherparepvec every 2 weeks for as long as you have tumor(s).
Talimogene laherparepvec should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
Precautions while using talimogene laherparepvec
Your doctor will check your progress closely while you are receiving talimogene laherparepvec. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.
Using talimogene laherparepvec while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
Talimogene laherparepvec can spread to other areas of the body or to other people (eg, household members, caregiver, or persons sharing the same bed). To avoid spreading the medicine:
- Avoid direct contact between your treatment sites, dressings, body fluids or close contacts. Do not touch or scratch the treatment sites.
- Wear gloves when putting on or changing your dressings.
- Cover the treatment sites with airtight and watertight dressings for at least 1 week after each treatment.
- If the dressing comes loose or falls off, use a new, clean dressing to replace it.
- Place all used dressings and cleaning materials in a sealed plastic bag and throw them in the trash can.
Talimogene laherparepvec may cause herpes infections (including cold sores). Tell your doctor right away if you have pain, burning, or tingling in a blister around the mouth or genitals or on the fingers or ears, confusion, extreme drowsiness, blurred vision, eye pain, sensitivity to light, or weakness in your arms or legs.
Talimogene laherparepvec may cause delayed healing at the injection site. It is more likely to occur if you had previous radiation treatment at the injection site or lesions. Tell your doctor right away if you have infection or delayed healing of the injection sites.
Immune-mediated events may occur while receiving talimogene laherparepvec. These include glomerulonephritis, pneumonitis, psoriasis, vasculitis, or vitiligo. Tell your doctor if you have bloody or cloudy urine, swelling of the feet or lower legs, weight gain, fever, sores, welting, or blisters, or red, scaling, or crusted skin.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Talimogene laherparepvec side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- general feeling of discomfort or illness
- joint pain
- loss of appetite
- muscle aches and pains
- pain at the injection site
- runny nose
- sore throat
- trouble sleeping
- unusual tiredness or weakness
Incidence not known
- Break in the skin, especially associated with blue-black discoloration, swelling, or drainage of fluid
- burning or stinging of the skin
- painful cold sores or blisters on the lips, nose, eyes, or genitals
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Abdominal or stomach pain
- difficulty having a bowel movement (stool)
- difficulty with moving
- muscle pain or stiffness
- pain in the arms or legs
- weight loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
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Reference from: https://www.drugs.com/cons/talimogene-laherparepvec-injection.html