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Generic Name: efavirenz (e FAV ir enz)
Brand Names:Sustiva
Medically reviewed by Philip Thornton, DipPharm Last updated on Jan 7, 2020.
What is Sustiva?
Sustiva (efavirenz) is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.
Sustiva is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).
Sustiva is for adults and children who are at least 3 months old and weigh at least 8 pounds. This medicine is not a cure for HIV or AIDS.
Important Information
You should not use Sustiva if you also take elbasvir and grazoprevir (Zepatier) to treat hepatitis C.
Sustiva may cause serious psychiatric symptoms including confusion, severe depression, suicidal thoughts, aggression, extreme fear, hallucinations, or unusual behavior. Contact your doctor at once if you have any of these side effects, even if you have had them before.
Do not use efavirenz without telling your doctor if you are pregnant. It could harm the unborn baby. Use two forms of birth control, including a barrier form (such as a condom or diaphragm with spermicide gel) while you are taking this medicine, and for at least 12 weeks after your treatment ends. Tell your doctor if you become pregnant during treatment.
Taking Sustiva will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Before taking this medicine
You should not use Sustiva if you are allergic to efavirenz, or if you also take elbasvir and grazoprevir (Zepatier) to treat hepatitis C.
Do not take with Atripla (combination efavirenz, emtricitabine, and tenofovir), unless your doctor tells you to.
Tell your doctor if you have ever had:
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liver disease (including hepatitis B or C);
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long QT syndrome;
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a seizure;
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mental illness or psychosis;
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heart disease; or
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if you drink large amounts of alcohol or have a history of injection drug use.
Do not use Sustiva if you are pregnant. It could harm the unborn baby or cause birth defects. Use 2 forms of birth control, including a barrier form (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy while you are using this medicine and for at least 12 weeks after your last dose. Tell your doctor if you become pregnant during treatment.
Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while you are taking Sustiva.
HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
How should I take Sustiva?
Take Sustiva exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Sustiva must be given in combination with other antiviral medications and it should not be used alone. Your disease may become resistant to efavirenz if you do not take it in combination with other HIV medicines your doctor has prescribed.
Take Sustiva on an empty stomach at bedtime.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Swallow the tablet whole and do not crush, chew, or break it.
If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce, yogurt, grape jelly, or infant formula (if you are giving the medicine to a baby). Swallow the mixture right away. Do not save it for later use.
After taking Sustiva using the sprinkle method, do not eat for the next 2 hours. If you give Sustiva mixed with infant formula to a baby, do not feed more formula for at least 2 hours afterward.
Efavirenz doses are based on weight in children. Your child’s dose needs may change if the child gains or loses weight.
You will need frequent medical tests.
Take Sustiva regularly to get the most benefit. Skipping doses may increase the risk of your virus becoming resistant to antiviral medicine.
Store at room temperature away from moisture and heat.
This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use efavirenz.
Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor’s advice. Every person with HIV should remain under the care of a doctor.
Sustiva dosing information
Usual Adult Dose for HIV Infection:
600 mg orally once a day
Comments:
-This drug should be used with a protease inhibitor and/or NRTIs.
Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection
Usual Adult Dose for Nonoccupational Exposure:
US CDC recommendations: 600 mg orally once a day
Duration of therapy: 28 days
Comments:
-This drug should be used with (lamivudine or emtricitabine) plus (zidovudine or tenofovir); recommended as the preferred NNRTI-based regimen for nonoccupational postexposure prophylaxis of HIV infection.
-Prophylaxis should be started as soon as possible, within 72 hours of exposure.
-Not approved by US FDA.
Usual Adult Dose for Occupational Exposure:
US Public Health Service working group recommendations: 600 mg orally once a day
Duration of therapy: 28 days, if tolerated
Comments:
-An alternative antiretroviral agent for use as HIV postexposure prophylaxis only with expert consultation
-Prophylaxis should be started as soon as possible, preferably within hours after exposure.
-The optimal duration of prophylaxis is unknown and may differ based on institution protocol.
-The most current therapeutic guidelines should be consulted for more information.
-Not approved by US FDA.
Usual Pediatric Dose for HIV Infection:
3 months or older:
3.5 to less than 5 kg: 100 mg orally once a day
5 to less than 7.5 kg: 150 mg orally once a day
7.5 to less than 15 kg: 200 mg orally once a day
15 to less than 20 kg: 250 mg orally once a day
20 to less than 25 kg: 300 mg orally once a day
25 to less than 32.5 kg: 350 mg orally once a day
32.5 to less than 40 kg: 400 mg orally once a day
40 kg or more: 600 mg orally once a day
Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Get your prescriptions refilled before you run out of medicine completely.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while taking Sustiva?
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Drinking alcohol can increase certain side effects of efavirenz.
Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Sustiva side effects
Get emergency medical help if you have signs of an allergic reaction to Sustiva: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
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a seizure;
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hallucinations, trouble concentrating, trouble speaking or moving (these symptoms may occur months or years after you start taking efavirenz);
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nervous system problems – dizziness, drowsiness, confusion, trouble concentrating, strange dreams, insomnia, or problems with speech, balance, or muscle movement;
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serious psychiatric symptoms – anxiety, paranoia, unusual behavior, feeling sad or hopeless, hallucinations, suicidal thoughts; or
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liver problems – nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
Sustiva may cause serious psychiatric symptoms including confusion, feeling sad or hopeless, suicidal thoughts, anxiety, paranoia, hallucinations, trouble speaking or moving, or unusual behavior. Contact your doctor at once if you have any of these side effects, even if you have had them before.
Efavirenz affects your immune system, which may cause certain side effects (even weeks or months after you’ve taken this medicine). Tell your doctor if you have:
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signs of a new infection – fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
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trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
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swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.
Common Sustiva side effects may include:
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nausea, vomiting;
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dizziness, drowsiness, trouble concentrating;
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rash;
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headache, tired feeling;
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sleep problems (insomnia), strange dreams; or
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changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Sustiva?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Sustiva can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Other drugs may interact with efavirenz, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sustiva only for the indication prescribed.
Copyright 1996-2020 Cerner Multum, Inc. Version: 18.01.
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Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Sustiva and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/sustiva.html