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Generic Name: ertugliflozin and sitagliptin
Medically reviewed by P. Thornton, DipPharm Last updated on Feb 14, 2019.
What is Steglujan?
Steglujan contains a combination of ertugliflozin and sitagliptin. Ertugliflozin and sitagliptin help control blood sugar levels. Ertugliflozin works by helping the kidneys get rid of glucose from your bloodstream. Sitagliptin works by regulating the levels of insulin your body produces after eating.
Steglujan is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Steglujan is not for treating type 1 diabetes.
You should not use Steglujan if you have severe kidney disease, if you are on dialysis, or if you have diabetic ketoacidosis.
This medicine can make you dehydrated, which could cause you to feel weak or dizzy (especially when you stand up).
Stop taking Steglujan and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, with or without nausea and vomiting.
In rare cases, this medicine can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don’t feel well.
Before taking this medicine
You should not use Steglujan if you are allergic to ertugliflozin o sitagliptin, or if you have:
severe kidney disease (or if you are on dialysis); or
diabetic ketoacidosis (call your doctor for treatment).
To make sure Steglujan is safe for you, tell your doctor if you have ever had:
liver or kidney disease;
a bladder infection or urination problems;
problems with your pancreas, including surgery;
a diabetic foot ulcer or amputation;
heart problems, high or low blood pressure;
blood circulation problems, especially in your legs;
nerve damage in your legs;
high triglycerides (a type of fat in blood);
if you are on a low salt diet.
Ertugliflozin may harm an unborn baby if you take the medicine during your second or third trimester. Tell your doctor if you become pregnant while using Steglujan.
You should not breast-feed while using this medicine.
Steglujan is not approved for use by anyone younger than 18 years old.
How should I take Steglujan?
Steglujan is usually taken once per day in the morning. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
You may take Steglujan with or without food.
Call your doctor if you are sick with vomiting or diarrhea, if you consume less food or fluid than usual, or if you are sweating more than usual.
Your blood sugar will need to be checked often, and you may also need to test the level of ketones your urine. Ertugliflozin can cause life-threatening ketoacidosis (too much acid in the blood). Even if your blood sugar is normal, contact your doctor if a urine test shows that you have ketones in the urine.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
This medicine can cause unusual results with certain lab tests. Tell any doctor who treats you that you are using Steglujan.
Store at room temperature away from moisture and heat. Keep unused tablets in the foil blister pack in its original container.
Steglujan dosing information
Usual Adult Dose for Diabetes Type 2:
Initial dose: 1 tablet (ertugliflozin 5 mg/sitagliptin 100 mg) orally once a day
-For patients tolerating therapy and requiring additional glycemic control, may increase to 1 tablet (ertugliflozin 15 mg/sitagliptin 100 mg) orally once a day
Maximum dose: ertugliflozin 15 mg/sitagliptin 100 mg per day
For patients already receiving ertugliflozin: Switch to combination product with same ertugliflozin dose
-Volume depletion should be corrected prior to initiating therapy.
-This drug is not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
-This drug has not been studied in patients with a history of pancreatitis; it is not known whether this may increase the risk of developing pancreatitis during therapy.
Use: An adjunct to diet and exercise to improve glycemic control in adults with Type 2 diabetes mellitus when treatment with both Steglujan is appropriate.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while taking Steglujan?
Avoid drinking alcohol.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Steglujan side effects
Get emergency medical help if you have signs of an allergic reaction to Steglujan (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical attention right away if you have signs of a rare but serious genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.
Call your doctor at once if you have:
severe autoimmune reaction – itching, blisters, breakdown of the outer layer of skin;
new pain, tenderness, sores, ulcers, or infections in your legs or feet;
severe or ongoing pain in your joints;
little or no urination;
ketoacidosis (too much acid in the blood) – nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing;
dehydration symptoms – dizziness, weakness, feeling light-headed (like you might pass out);
signs of a bladder infection – pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back;
symptoms of heart failure – shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain; or
symptoms of pancreatitis – severe pain in your upper stomach spreading to your back, with or without nausea and vomiting.
Some side effects may be more likely to occur in older adults.
Common Steglujan side effects may include:
urinating more than usual;
upset stomach, diarrhea;
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Steglujan?
When you start or stop taking Steglujan, your doctor may need to adjust the doses of any other diabetes medicines you use on a regular basis.
Other drugs may interact with ertugliflozin and sitagliptin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Steglujan only for the indication prescribed.
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The content of Holevn is solely for the purpose of providing information about Thuốc Steglujan and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/steglujan.html