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Generic Name: sofosbuvir and velpatasvir (soe FOS bue vir and vel PAT as vir)
Brand Name:Epclusa
Medically reviewed by Holevn.org on Nov 20, 2019 – Written by Cerner Multum
What is sofosbuvir and velpatasvir?
Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults.
sofosbuvir and velpatasvir is sometimes given in combination with another antiviral medicine called ribavirin in people who also have advanced cirrhosis.
Sofosbuvir and velpatasvir treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.
Sofosbuvir and velpatasvir is sometimes used in people who also have HIV. This medicine is not a treatment for HIV or AIDS.
Sofosbuvir and velpatasvir may also be used for purposes not listed in this medication guide.
Important Information
If you have ever had hepatitis B, this medicine can cause the condition to come back or get worse. You will need frequent blood tests to check your liver function.
Sofosbuvir and velpatasvir is sometimes used in combination with other medication. Read the medication guide or patient instructions provided with each medication in your combination therapy.
Before taking this medicine
You should not use sofosbuvir and velpatasvir if you are allergic to sofosbuvir or velpatasvir.
If you take sofosbuvir and velpatasvir with other antiviral medicines: There may be other reasons you should not take this combination treatment. Tell your doctor about all your medical conditions.
Tell your doctor if you have ever had:
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hepatitis B;
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liver problems other than hepatitis C;
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kidney disease (or if you are on dialysis);
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diabetes;
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HIV (human immunodeficiency virus); or
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if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine “INR” or prothrombin time tests.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Sofosbuvir and velpatasvir is sometimes used in combination with ribavirin. Ribavirin can cause birth defects or death in an unborn baby.
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If you are a woman, do not use ribavirin if you are pregnant. You may need to have a negative pregnancy test before taking ribavirin and every month during your treatment.
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If you are a man, do not use ribavirin if your sexual partner is pregnant. An unborn baby could be harmed if you have sex with a pregnant woman while you are taking ribavirin.
While taking sofosbuvir and velpatasvir with ribavirin, use at least 2 effective forms of birth control to prevent pregnancy, whether you are a man or a woman. Ribavirin use by either parent may cause birth defects.
Keep using 2 forms of birth control for at least 6 months after your last dose of ribavirin. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ribavirin.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How should I take sofosbuvir and velpatasvir?
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using this medicine.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
You may take this medicine with or without food.
You will need frequent blood tests to check your liver function.
Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor’s advice. Every person with chronic hepatitis C should remain under the care of a doctor.
You should not stop using sofosbuvir and velpatasvir suddenly. Stopping suddenly could make your hepatitis C harder to treat with antiviral medicine.
If you have ever had hepatitis B, using sofosbuvir and velpatasvir can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.
Store this medicine in the original container at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Get your prescription refilled before you run out of medicine completely.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while taking sofosbuvir and velpatasvir?
Using sofosbuvir and velpatasvir will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Sofosbuvir and velpatasvir side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have new or worsening symptoms such as:
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loss of appetite, upper stomach pain;
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dark urine, clay-colored stools; or
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jaundice (yellowing of the skin or eyes).
If you also take a heart rhythm medicine called amiodarone: Taking amiodarone with sofosbuvir and velpatasvir can cause dangerous side effects on your heart. Get medical help right away if you take these medicines and you have:
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very slow heartbeats, chest pain, shortness of breath;
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confusion, memory problems; or
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weakness, extreme tiredness, light-headed feeling (like you might pass out).
Common side effects may include:
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headache;
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tiredness;
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nausea, diarrhea; or
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sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Sofosbuvir and velpatasvir dosing information
Usual Adult Dose for Chronic Hepatitis C:
1 tablet orally once a day
Recommended Regimen and Duration of Therapy:
-Therapy-naive and therapy-experienced, without cirrhosis and with compensated cirrhosis (Child-Pugh A): Sofosbuvir-velpatasvir for 12 weeks
-Therapy-naive and therapy-experienced, with decompensated cirrhosis (Child-Pugh B or C): Sofosbuvir-velpatasvir plus ribavirin for 12 weeks
Comments:
-Dose recommendations also apply to HCV/HIV-1-coinfected patients.
-In clinical trials, therapy-experienced patients received a peginterferon alfa/ribavirin-based regimen with or without an HCV nonstructural protein 3/4A (NS3/4A) protease inhibitor (boceprevir, simeprevir, or telaprevir).
-If applicable, the manufacturer product information should be consulted for ribavirin dose recommendations; the manufacturer product information for ribavirin should be consulted for further information regarding dosing and dose adjustments.
Uses: For the treatment of chronic HCV genotype 1, 2, 3, 4, 5, or 6 infection
-In patients without cirrhosis or with compensated cirrhosis
-In combination with ribavirin: In patients with decompensated cirrhosis
What other drugs will affect sofosbuvir and velpatasvir?
When you start or stop taking sofosbuvir and velpatasvir, your doctor may need to adjust the doses of any other medicines you take on a regular basis.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
If you also take omeprazole (Prilosec) or an antacid, do not take it for at least 4 hours after you have taken your dose of sofosbuvir and velpatasvir (with food).
Many drugs can affect sofosbuvir and velpatasvir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 4.01.
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Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Sofosbuvir and velpatasvir and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/sofosbuvir-and-velpatasvir.html
