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Generic Name: rolapitant (roe LA pi tant)
Medically reviewed by Holevn.org on Apr 10, 2019 – Written by Cerner Multum
What is rolapitant?
Rolapitant is used together with other medicines to prevent nausea and vomiting caused by cancer chemotherapy.
Rolapitant may also be used for purposes not listed in this medication guide.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Before taking this medicine
Some medicines can cause unwanted or dangerous effects when used with rolapitant. Your doctor may change your treatment plan if you also use:
Tell your doctor if you have ever had:
Tell your doctor if you are pregnant or breastfeeding.
rolapitant may affect fertility (your ability to have children) for a short time.
Rolapitant is not approved for use by anyone younger than 18 years old.
How should I use rolapitant?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Rolapitant is usually given on Day 1 of your chemotherapy treatment.
Rolapitant is given either as a tablet taken by mouth, or as an injection infused into a vein. A healthcare provider will give the injection.
You may take rolapitant tablets with or without food.
You should not take rolapitant tablets more than once every 14 days.
You will be given other medication to prevent nausea or vomiting. Keep using these medicines for as long as your doctor has prescribed. Read the medication guide or patient instructions provided with each medication.
Store the tablets at room temperature away from moisture and heat.
What happens if I miss a dose?
Call your doctor for instructions if you forget to take the tablets at the correct time before chemotherapy. The timing of your rolapitant dose is important for rolapitant to be effective.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid after using rolapitant?
For at least 1 month after you use rolapitant, avoid using any cough or cold medicine that contains dextromethorphan. Talk to your doctor about how to best treat a cough due to the common cold.
Rolapitant side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pain or burning when you urinate;
low red blood cells (anemia)–pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
low white blood cell counts–fever, swollen gums, painful mouth sores, skin sores, cold or flu symptoms, cough, trouble breathing.
Common side effects may include:
low blood cell counts;
loss of appetite.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Rolapitant dosing information
Usual Adult Dose for Nausea/Vomiting — Chemotherapy Induced:
180 mg orally approximately 1 to 2 hours prior to initiation of each chemotherapy cycle.
Comments: Dexamethasone and a 5-HT3 receptor antagonist should be administered concurrently with rolapitant. Consult manufacturer product information for appropriate dosing information for these drugs.
Use: In combination with other antiemetic agents for prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.
What other drugs will affect rolapitant?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect rolapitant, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using. For at least 28 days after you use rolapitant, it could affect other medicines you are using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 6.01.
The content of Holevn is solely for the purpose of providing information about Thuốc Rolapitant and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/rolapitant.html