Holevn Health share articles about :Thuốc Rho(d) immune globulin , side effects – dosage , Thuốc Rho(d) immune globulin what disease treatment.Other noted issues. Please refer to the details below.
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Intravascular hemolysis (IVH) leading to death has been reported in patients treated for immune thrombocytopenic purpura (ITP) with Rho(D) immune globulin. IVH can lead to clinically compromising anemia and multi-system organ failure, including acute respiratory distress syndrome (ARDS), acute renal insufficiency, renal failure, and disseminated intravascular coagulation (DIC). Alert patients and closely monitor for the signs and symptoms of IVH in a health care setting for at least 8 hours after administration for ITP. Perform a dipstick urinalysis at baseline, 2 hours, 4 hours after administration, and prior to the end of the monitoring period. If signs and/or symptoms of IVH are present or suspected, post-treatment laboratory tests should be performed .
Medically reviewed by Holevn.org. Last updated on Apr 7, 2019.
Commonly used brand name(s)
In the U.S.
- HyperRHO S/D
- MicRhogam Ultra-Filtered
- RhoGAM Ultra-Filtered Plus
- WinRho SDF
- Winrho SDF
Available Dosage Forms:
Therapeutic Class: Immune Serum
Uses for rho(d) immune globulin
Rho(D) immune globulin is used to treat immune thrombocytopenic purpura (ITP) in patients with Rh-positive blood. ITP is a type of blood disorder where the person has a very low number of platelets. Platelets help to clot the blood. Rho(D) immune globulin is also used to prevent antibodies from forming after a person with Rh-negative blood receives a transfusion with Rh-positive blood, or during pregnancy when a mother has Rh-negative blood and the baby is Rh-positive. It belongs to a group of medicines called immunizing agents. Rho(D) immune globulin works to boost the immune system and prevent excessive bleeding.
The Rh factor is one part of the red blood cell. A person has either Rh-positive or Rh-negative blood. If you receive the opposite type of blood, your body will create antibodies that can destroy the red blood cells. When a pregnant woman is Rh-negative and her baby is Rh-positive, the baby’s blood can get into her system and cause her to make antibodies. When the same woman has a second baby with Rh-positive blood, the antibodies will destroy the red blood cells in the baby. Rho(D) immune globulin is given to these women during pregnancy or after delivery to prevent them from making antibodies.
Rho(d) immune globulin is to be administered only by or under the supervision of your doctor.
Before using rho(d) immune globulin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rho(d) immune globulin, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to rho(d) immune globulin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Rho(D) immune globulin in children. It is not recommended for an infant with Rh-positive blood whose mother is Rh-negative.
Although appropriate studies on the relationship of age to the effects of Rho(D) immune globulin have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of Rho(D) immune globulin in the elderly. However, elderly patients are more likely to have age-related heart, kidney, or liver problems, and might have conditions that require an adjustment in the dose for patients receiving Rho(D) immune globulin.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of rho(d) immune globulin. Make sure you tell your doctor if you have any other medical problems, especially:
- Anemia, severe or
- Blood clotting problems, history of or
- Breathing problems, severe or
- Disseminated intravascular coagulation (blood clotting problem) or
- Kidney problems or
- Pulmonary edema (fluid in the lungs), history of—Use with caution. May make these conditions worse.
- Atherosclerosis (hardening of the arteries), history of or
- Heart or blood vessel problems or
- Hyperviscosity (thick blood), history of or
- Stroke—Use with caution. May cause side effects to become worse.
- Autoimmune hemolytic anemia (bleeding problem) or
- Hemolysis, active (red blood cells are being destroyed) or
- Immunoglobulin A (IgA) deficiency with antibodies against IgA—Should not be used in patients with these conditions.
- Diabetes—The liquid form of WinRho® contains maltose. Some glucose testing systems will not work properly if maltose is in the blood. Discuss this with your doctor.
Proper use of rho(d) immune globulin
A nurse or other trained health professional will give you rho(d) immune globulin in a hospital. Rho(d) immune globulin is given through a needle placed in one of your veins or as a shot into one of your muscles.
Precautions while using rho(d) immune globulin
It is very important that your doctor check the progress of you or your child at regular visits for any problems or unwanted effects that may be caused by rho(d) immune globulin. Blood and urine tests may be needed to check for unwanted effects.
Check with your doctor right away if you or your child have back pain; shaking chills; a fever; dark urine; a decreased amount of urine; a sudden weight gain; swelling of the hands or feet; or shortness of breath after receiving rho(d) immune globulin. These may be symptoms of a serious blood problem called intravascular hemolysis (IVH).
Rho(d) immune globulin is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made from human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the making of these medicines. Although the risk is low, talk with your doctor if you have concerns.
Rho(d) immune globulin may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have itching, a rash, hives, chest pain, dizziness or lightheadedness, trouble breathing, or any swelling of your hands, face, or mouth after you receive rho(d) immune globulin.
Rho(d) immune globulin may cause blood clots, especially in patients with a history of blood clotting problems, heart disease, and atherosclerosis (hardening of the arteries) or circulation problems. Patients who stay in bed for a long time because of surgery or illness may also have blood clots. Check with your doctor right away if you or your child suddenly have chest pain, shortness of breath, a severe headache, leg pain, or problems with vision, speech, or walking.
Rho(d) immune globulin may cause a rare and serious lung problem a few hours after it is given. Tell your doctor right away if you or your child have any breathing problems with or without a fever after you receive the medicine.
While you are being treated with Rho(D) immune globulin, do not have any immunizations (vaccines) without your doctor’s approval. Live virus vaccines should not be given for 3 months after receiving Rho(D) immune globulin.
Rho(d) immune globulin side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Bloody urine
- decreased frequency of urination or amount of urine
- increased blood pressure
- increased thirst
- loss of appetite
- lower back pain
- nausea or vomiting
- pale skin
- swelling of the face, fingers, or lower legs
- troubled breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- weight gain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Soreness at the place of injection
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
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Reference from: https://www.drugs.com/cons/rho-d-immune-globulin-intravenous-intramuscular-injection.html