Thuốc Ondansetron

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Thuốc Ondansetron
Thuốc Ondansetron
  • Sorafenib
  • Sotalol
  • Sufentanil
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Tizanidine
  • Tolterodine
  • Toremifene
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vinflunine
  • Voriconazole
  • Vorinostat
    • Zuclopenthixol
    • Using ondansetron with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

      • Cyclophosphamide

      Interactions with food/tobacco/alcohol

      Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

      Using ondansetron with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ondansetron, or give you special instructions about the use of food, alcohol, or tobacco.

      • Tobacco

      Other medical problems

      The presence of other medical problems may affect the use of ondansetron. Make sure you tell your doctor if you have any other medical problems, especially:

      • Allergy to other selective 5-HT3 receptor antagonists (eg, alosetron [Lotronex®], dolasetron [Anzemet®], granisetron [Kytril®], palonosetron [Aloxi®])—Use with caution. It is likely you will also be allergic to ondansetron.
      • Bowel blockage or
      • Gastric distension (enlarged abdomen)—May cover up symptoms of these stomach or intestinal problems.
      • Congestive heart failure or
      • Heart rhythm problems (eg, prolonged QT interval, slow heartbeat) or
      • Hypokalemia (low potassium in the blood) or
      • Hypomagnesemia (low magnesium in the blood)—Use with caution. May make these conditions worse.
      • Heart rhythm problems (eg, congenital long QT syndrome)—Avoid use in patients with this condition.
      • Liver disease—May have an increased chance of side effects.
      • Phenylketonuria (PKU)—The oral disintegrating tablets may contain aspartame, which can make your condition worse.

      Proper use of ondansetron

      Take ondansetron only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

      To use the oral disintegrating tablet:

      • Make sure your hands are dry.
      • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
      • Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

      To use the oral soluble film:

      • Make sure your hands are clean and dry before and after using ondansetron.
      • Fold the pouch along the dotted line to expose the tear notch.
      • While still folded, tear the pouch carefully along the edge and remove the film out from the pouch.
      • Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole.
      • Once the film is dissolved, you may swallow with or without water.

      If you vomit within 30 minutes after using ondansetron, take the same amount of medicine again. If vomiting continues, check with your doctor.

      Ondansetron comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

      Dosing

      The dose of ondansetron will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of ondansetron. If your dose is different, do not change it unless your doctor tells you to do so.

      The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    • For oral dosage forms (oral disintegrating tablets, solution, or tablets):
      • For prevention of moderate nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days.
        • Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days.
        • Children younger than 4 years of age—Use and dose must be determined by your doctor.
      • For prevention of more severe nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment.
        • Children younger than 12 years of age—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after radiation treatment:
        • Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after surgery:
        • Adults—16 milligrams (mg) one hour before anesthesia is given.
        • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (soluble film):
      • For prevention of moderate nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days.
        • Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days.
        • Children younger than 4 years of age—Use and dose must be determined by your doctor.
      • For prevention of more severe nausea and vomiting after treatment with cancer medicines:
        • Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after radiation treatment:
        • Adults—One 8-milligram (mg) film three times a day.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after surgery:
        • Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film.
        • Children—Use and dose must be determined by your doctor.
    • Missed dose

      If you miss a dose of ondansetron, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

      If you miss a dose of ondansetron, and you feel nauseated or you vomit, take the missed dose as soon as possible.

      Storage

      Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

      Keep out of the reach of children.

      Do not keep outdated medicine or medicine no longer needed.

      Ask your healthcare professional how you should dispose of any medicine you do not use.

      Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

      Keep the unused soluble film in the foil pouch until you ready to use it.

      Precautions while using ondansetron

      Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

      Do not use ondansetron if you are receiving apomorphine (Apokyn®). Using these medicines together may increase risk for more serious problems.

      Ondansetron may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using ondansetron.

      Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

      Check with your doctor right away if you start to have pain or swelling in your stomach area. These may be signs of a serious stomach or bowel problem.

      Ondansetron may make you dizzy. Do not drive or do anything else that could be dangerous until you know how ondansetron affects you.

      Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

      Ondansetron side effects

      Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

      Check with your doctor immediately if any of the following side effects occur:

      More common

      • Confusion
      • dizziness
      • fast heartbeat
      • fever
      • headache
      • shortness of breath
      • weakness

      Less common

      • Decrease in the frequency of urination
      • decrease in the urine volume
      • difficulty with passing urine (dribbling)
      • painful urination

      Rare

      • Arm, back, or jaw pain
      • chest pain or discomfort
      • chest tightness or heaviness
      • convulsions
      • cough
      • decreased urine
      • difficulty with breathing
      • difficulty with swallowing
      • dry mouth
      • fast, pounding, or irregular heartbeat or pulse
      • increased thirst
      • loss of appetite
      • loss of bladder control
      • loss of consciousness
      • mood changes
      • muscle pain or cramps
      • nausea or vomiting
      • noisy breathing
      • numbness or tingling in the hands, feet, or lips
      • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
      • skin rash, hives, or itching
      • sweating
      • tightness in the chest
      • total body jerking
      • unusual tiredness or weakness
      • wheezing

      Incidence not known

      • Blurred vision
      • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
      • fixed position of the eye
      • heart stops
      • hoarseness
      • inability to move the eyes
      • increased blinking or spasms of the eyelid
      • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
      • no breathing
      • no pulse or blood pressure
      • noisy breathing
      • pounding heartbeat
      • slow or irregular breathing
      • sticking out of the tongue
      • sweating
      • trouble with speaking
      • unconscious
      • uncontrolled twisting movements of the neck, trunk, arms, or legs
      • unusual facial expressions

      Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

      More common

      • Anxiety
      • difficulty having a bowel movement (stool)
      • dry mouth
      • general feeling of discomfort or illness
      • hyperventilation
      • irritability
      • restlessness
      • shaking
      • trouble sleeping

      Rare

      • Difficulty with speaking
      • drooling
      • loss of balance control
      • muscle trembling, jerking, or stiffness
      • shuffling walk
      • stiffness of the limbs
      • twisting movements of the body
      • uncontrolled movements, especially of the face, neck, and back

      Incidence not known

      • Feeling of warmth
      • hiccups
      • redness of the face, neck, arms, and occasionally, upper chest
      • redness of the skin
      • welts

      Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

      Seek emergency medical attention or call 115

      Further information

      Related questions

      The content of Holevn is solely for the purpose of providing information about Thuốc Ondansetron  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

      Reference from: https://www.drugs.com/cons/ondansetron-oral-oromucosal.html

    • Sorafenib
    • Sotalol
    • Sufentanil
    • Sulpiride
    • Sunitinib
    • Tacrolimus
    • Tamoxifen
    • Tapentadol
    • Tedisamil
    • Telavancin
    • Telithromycin
    • Tetrabenazine
    • Tizanidine
    • Tolterodine
    • Toremifene
    • Tramadol
    • Trazodone
    • Triclabendazole
    • Trifluoperazine
    • Trimipramine
    • Triptorelin
    • Vandetanib
    • Vardenafil
    • Vemurafenib
    • Venlafaxine
    • Vinflunine
    • Voriconazole
    • Vorinostat
    • Zuclopenthixol
    • Using ondansetron with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

      • Cyclophosphamide

      Interactions with food/tobacco/alcohol

      Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

      Using ondansetron with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ondansetron, or give you special instructions about the use of food, alcohol, or tobacco.

      • Tobacco

      Other medical problems

      The presence of other medical problems may affect the use of ondansetron. Make sure you tell your doctor if you have any other medical problems, especially:

      • Allergy to other selective 5-HT3 receptor antagonists (eg, alosetron [Lotronex®], dolasetron [Anzemet®], granisetron [Kytril®], palonosetron [Aloxi®])—Use with caution. It is likely you will also be allergic to ondansetron.
      • Bowel blockage or
      • Gastric distension (enlarged abdomen)—May cover up symptoms of these stomach or intestinal problems.
      • Congestive heart failure or
      • Heart rhythm problems (eg, prolonged QT interval, slow heartbeat) or
      • Hypokalemia (low potassium in the blood) or
      • Hypomagnesemia (low magnesium in the blood)—Use with caution. May make these conditions worse.
      • Heart rhythm problems (eg, congenital long QT syndrome)—Avoid use in patients with this condition.
      • Liver disease—May have an increased chance of side effects.
      • Phenylketonuria (PKU)—The oral disintegrating tablets may contain aspartame, which can make your condition worse.

      Proper use of ondansetron

      Take ondansetron only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

      To use the oral disintegrating tablet:

      • Make sure your hands are dry.
      • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
      • Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

      To use the oral soluble film:

      • Make sure your hands are clean and dry before and after using ondansetron.
      • Fold the pouch along the dotted line to expose the tear notch.
      • While still folded, tear the pouch carefully along the edge and remove the film out from the pouch.
      • Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole.
      • Once the film is dissolved, you may swallow with or without water.

      If you vomit within 30 minutes after using ondansetron, take the same amount of medicine again. If vomiting continues, check with your doctor.

      Ondansetron comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

      Dosing

      The dose of ondansetron will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of ondansetron. If your dose is different, do not change it unless your doctor tells you to do so.

      The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    • For oral dosage forms (oral disintegrating tablets, solution, or tablets):
      • For prevention of moderate nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days.
        • Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days.
        • Children younger than 4 years of age—Use and dose must be determined by your doctor.
      • For prevention of more severe nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment.
        • Children younger than 12 years of age—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after radiation treatment:
        • Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after surgery:
        • Adults—16 milligrams (mg) one hour before anesthesia is given.
        • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (soluble film):
      • For prevention of moderate nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days.
        • Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days.
        • Children younger than 4 years of age—Use and dose must be determined by your doctor.
      • For prevention of more severe nausea and vomiting after treatment with cancer medicines:
        • Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after radiation treatment:
        • Adults—One 8-milligram (mg) film three times a day.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after surgery:
        • Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film.
        • Children—Use and dose must be determined by your doctor.
    • Missed dose

      If you miss a dose of ondansetron, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

      If you miss a dose of ondansetron, and you feel nauseated or you vomit, take the missed dose as soon as possible.

      Storage

      Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

      Keep out of the reach of children.

      Do not keep outdated medicine or medicine no longer needed.

      Ask your healthcare professional how you should dispose of any medicine you do not use.

      Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

      Keep the unused soluble film in the foil pouch until you ready to use it.

      Precautions while using ondansetron

      Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

      Do not use ondansetron if you are receiving apomorphine (Apokyn®). Using these medicines together may increase risk for more serious problems.

      Ondansetron may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using ondansetron.

      Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

      Check with your doctor right away if you start to have pain or swelling in your stomach area. These may be signs of a serious stomach or bowel problem.

      Ondansetron may make you dizzy. Do not drive or do anything else that could be dangerous until you know how ondansetron affects you.

      Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

      Ondansetron side effects

      Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

      Check with your doctor immediately if any of the following side effects occur:

      More common

      • Confusion
      • dizziness
      • fast heartbeat
      • fever
      • headache
      • shortness of breath
      • weakness

      Less common

      • Decrease in the frequency of urination
      • decrease in the urine volume
      • difficulty with passing urine (dribbling)
      • painful urination

      Rare

      • Arm, back, or jaw pain
      • chest pain or discomfort
      • chest tightness or heaviness
      • convulsions
      • cough
      • decreased urine
      • difficulty with breathing
      • difficulty with swallowing
      • dry mouth
      • fast, pounding, or irregular heartbeat or pulse
      • increased thirst
      • loss of appetite
      • loss of bladder control
      • loss of consciousness
      • mood changes
      • muscle pain or cramps
      • nausea or vomiting
      • noisy breathing
      • numbness or tingling in the hands, feet, or lips
      • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
      • skin rash, hives, or itching
      • sweating
      • tightness in the chest
      • total body jerking
      • unusual tiredness or weakness
      • wheezing

      Incidence not known

      • Blurred vision
      • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
      • fixed position of the eye
      • heart stops
      • hoarseness
      • inability to move the eyes
      • increased blinking or spasms of the eyelid
      • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
      • no breathing
      • no pulse or blood pressure
      • noisy breathing
      • pounding heartbeat
      • slow or irregular breathing
      • sticking out of the tongue
      • sweating
      • trouble with speaking
      • unconscious
      • uncontrolled twisting movements of the neck, trunk, arms, or legs
      • unusual facial expressions

      Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

      More common

      • Anxiety
      • difficulty having a bowel movement (stool)
      • dry mouth
      • general feeling of discomfort or illness
      • hyperventilation
      • irritability
      • restlessness
      • shaking
      • trouble sleeping

      Rare

      • Difficulty with speaking
      • drooling
      • loss of balance control
      • muscle trembling, jerking, or stiffness
      • shuffling walk
      • stiffness of the limbs
      • twisting movements of the body
      • uncontrolled movements, especially of the face, neck, and back

      Incidence not known

      • Feeling of warmth
      • hiccups
      • redness of the face, neck, arms, and occasionally, upper chest
      • redness of the skin
      • welts

      Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

      Seek emergency medical attention or call 115

      Further information

      Related questions

      The content of Holevn is solely for the purpose of providing information about Thuốc Ondansetron  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

      Reference from: https://www.drugs.com/cons/ondansetron-oral-oromucosal.html

    • Sorafenib
    • Sotalol
    • Sufentanil
    • Sulpiride
    • Sunitinib
    • Tacrolimus
    • Tamoxifen
    • Tapentadol
    • Tedisamil
    • Telavancin
    • Telithromycin
    • Tetrabenazine
    • Tizanidine
    • Tolterodine
    • Toremifene
    • Tramadol
    • Trazodone
    • Triclabendazole
    • Trifluoperazine
    • Trimipramine
    • Triptorelin
    • Vandetanib
    • Vardenafil
    • Vemurafenib
    • Venlafaxine
    • Vinflunine
    • Voriconazole
    • Vorinostat
    • Zuclopenthixol

    Using ondansetron with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

    • Cyclophosphamide

    Interactions with food/tobacco/alcohol

    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using ondansetron with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ondansetron, or give you special instructions about the use of food, alcohol, or tobacco.

    • Tobacco

    Other medical problems

    The presence of other medical problems may affect the use of ondansetron. Make sure you tell your doctor if you have any other medical problems, especially:

    • Allergy to other selective 5-HT3 receptor antagonists (eg, alosetron [Lotronex®], dolasetron [Anzemet®], granisetron [Kytril®], palonosetron [Aloxi®])—Use with caution. It is likely you will also be allergic to ondansetron.
    • Bowel blockage or
    • Gastric distension (enlarged abdomen)—May cover up symptoms of these stomach or intestinal problems.
    • Congestive heart failure or
    • Heart rhythm problems (eg, prolonged QT interval, slow heartbeat) or
    • Hypokalemia (low potassium in the blood) or
    • Hypomagnesemia (low magnesium in the blood)—Use with caution. May make these conditions worse.
    • Heart rhythm problems (eg, congenital long QT syndrome)—Avoid use in patients with this condition.
    • Liver disease—May have an increased chance of side effects.
    • Phenylketonuria (PKU)—The oral disintegrating tablets may contain aspartame, which can make your condition worse.

    Proper use of ondansetron

    Take ondansetron only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

    To use the oral disintegrating tablet:

    • Make sure your hands are dry.
    • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
    • Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

    To use the oral soluble film:

    • Make sure your hands are clean and dry before and after using ondansetron.
    • Fold the pouch along the dotted line to expose the tear notch.
    • While still folded, tear the pouch carefully along the edge and remove the film out from the pouch.
    • Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole.
    • Once the film is dissolved, you may swallow with or without water.

    If you vomit within 30 minutes after using ondansetron, take the same amount of medicine again. If vomiting continues, check with your doctor.

    Ondansetron comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

    Dosing

    The dose of ondansetron will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of ondansetron. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    • For oral dosage forms (oral disintegrating tablets, solution, or tablets):
      • For prevention of moderate nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days.
        • Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days.
        • Children younger than 4 years of age—Use and dose must be determined by your doctor.
      • For prevention of more severe nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment.
        • Children younger than 12 years of age—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after radiation treatment:
        • Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after surgery:
        • Adults—16 milligrams (mg) one hour before anesthesia is given.
        • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (soluble film):
      • For prevention of moderate nausea and vomiting after treatment with cancer medicines:
        • Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days.
        • Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days.
        • Children younger than 4 years of age—Use and dose must be determined by your doctor.
      • For prevention of more severe nausea and vomiting after treatment with cancer medicines:
        • Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after radiation treatment:
        • Adults—One 8-milligram (mg) film three times a day.
        • Children—Use and dose must be determined by your doctor.
      • For prevention of nausea and vomiting after surgery:
        • Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film.
        • Children—Use and dose must be determined by your doctor.

    Missed dose

    If you miss a dose of ondansetron, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    If you miss a dose of ondansetron, and you feel nauseated or you vomit, take the missed dose as soon as possible.

    Storage

    Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

    Keep out of the reach of children.

    Do not keep outdated medicine or medicine no longer needed.

    Ask your healthcare professional how you should dispose of any medicine you do not use.

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

    Keep the unused soluble film in the foil pouch until you ready to use it.

    Precautions while using ondansetron

    Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

    Do not use ondansetron if you are receiving apomorphine (Apokyn®). Using these medicines together may increase risk for more serious problems.

    Ondansetron may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using ondansetron.

    Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

    Check with your doctor right away if you start to have pain or swelling in your stomach area. These may be signs of a serious stomach or bowel problem.

    Ondansetron may make you dizzy. Do not drive or do anything else that could be dangerous until you know how ondansetron affects you.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

    Ondansetron side effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:

    More common

    • Confusion
    • dizziness
    • fast heartbeat
    • fever
    • headache
    • shortness of breath
    • weakness

    Less common

    • Decrease in the frequency of urination
    • decrease in the urine volume
    • difficulty with passing urine (dribbling)
    • painful urination

    Rare

    • Arm, back, or jaw pain
    • chest pain or discomfort
    • chest tightness or heaviness
    • convulsions
    • cough
    • decreased urine
    • difficulty with breathing
    • difficulty with swallowing
    • dry mouth
    • fast, pounding, or irregular heartbeat or pulse
    • increased thirst
    • loss of appetite
    • loss of bladder control
    • loss of consciousness
    • mood changes
    • muscle pain or cramps
    • nausea or vomiting
    • noisy breathing
    • numbness or tingling in the hands, feet, or lips
    • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    • skin rash, hives, or itching
    • sweating
    • tightness in the chest
    • total body jerking
    • unusual tiredness or weakness
    • wheezing

    Incidence not known

    • Blurred vision
    • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    • fixed position of the eye
    • heart stops
    • hoarseness
    • inability to move the eyes
    • increased blinking or spasms of the eyelid
    • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    • no breathing
    • no pulse or blood pressure
    • noisy breathing
    • pounding heartbeat
    • slow or irregular breathing
    • sticking out of the tongue
    • sweating
    • trouble with speaking
    • unconscious
    • uncontrolled twisting movements of the neck, trunk, arms, or legs
    • unusual facial expressions

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    More common

    • Anxiety
    • difficulty having a bowel movement (stool)
    • dry mouth
    • general feeling of discomfort or illness
    • hyperventilation
    • irritability
    • restlessness
    • shaking
    • trouble sleeping

    Rare

    • Difficulty with speaking
    • drooling
    • loss of balance control
    • muscle trembling, jerking, or stiffness
    • shuffling walk
    • stiffness of the limbs
    • twisting movements of the body
    • uncontrolled movements, especially of the face, neck, and back

    Incidence not known

    • Feeling of warmth
    • hiccups
    • redness of the face, neck, arms, and occasionally, upper chest
    • redness of the skin
    • welts

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Seek emergency medical attention or call 115

    Further information

    Related questions

    The content of Holevn is solely for the purpose of providing information about Thuốc Ondansetron  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

    Reference from: https://www.drugs.com/cons/ondansetron-oral-oromucosal.html

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