Holevn Health share articles about :Thuốc Olaratumab , side effects – dosage , Thuốc Olaratumab what disease treatment.Other noted issues. Please refer to the details below.
Generic Name: olaratumab (OH lar AT ue mab)
Brand Name:Lartruvo
Medically reviewed by Holevn.org on Nov 20, 2019 – Written by Cerner Multum
What is olaratumab?
Olaratumab is a monoclonal antibody that blocks a certain type of cell receptor in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body, which may help slow or stop tumor growth.
Olaratumab is used in combination with another cancer medicine called doxorubicin, to treat adults with soft tissue sarcoma. Olaratumab is used when your condition cannot be treated with surgery or radiation.
Olaratumab was approved by the US Food and Drug Administration (FDA) on an “accelerated” basis. In clinical studies, olaratumab was shown to lengthen survival time. However, further studies are needed to determine if olaratumab is effective in larger numbers of patients with soft tissue sarcoma.
Olaratumab may also be used for purposes not listed in this medication guide.
Important Information
Olaratumab can cause an infusion reaction during the injection. Tell your caregiver right away if you feel dizzy, light-headed, chilled, flushed, feverish, or short of breath.
You should not receive olaratumab if you are pregnant. Avoid pregnancy for at least 3 months after you stop using this medicine.
Before taking this medicine
You should not be treated with olaratumab if you are allergic to it.
To make sure olaratumab is safe for you, tell your doctor if you have:
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diabetes; or
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an electrolyte imbalance (such as low levels of potassium in your blood).
You should not receive olaratumab if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using olaratumab and for at least 3 months after your last dose.
It is not known whether olaratumab passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How is olaratumab given?
Olaratumab is injected into a vein through an IV. A healthcare provider will give you this injection.
Olaratumab is given in a 21-day treatment cycle. You may receive the medicine only during the first 2 weeks of each cycle, on Day 1 and Day 8 of the full cycle.
The day before you receive olaratumab, you may be given other IV medications to prevent certain side effects.
Olaratumab must be given slowly, and the IV infusion can take at least 60 minutes to complete.
For the first 8 treatment cycles, you will also be treated with doxorubicin.
Read all patient information and medication guides provided to you for each of your medications. Ask your doctor or pharmacist if you have any questions.
Your doctor will determine how long to treat you with olaratumab.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your olaratumab injection.
What happens if I overdose?
Since olaratumab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving olaratumab?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity.
Olaratumab side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, chilled, flushed, feverish, or short of breath, or if you have a cold sweat, chest tightness, or trouble breathing.
Call your doctor at once if you have:
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sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;
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easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
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fever, cough, cold or flu symptoms;
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swollen gums;
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skin sores; or
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trouble breathing.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
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nausea, vomiting, stomach pain, diarrhea, loss of appetite;
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feeling tired;
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muscle or joint pain;
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numbness, weakness, or pain in your hands or feet;
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hair loss; or
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headache.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Olaratumab dosing information
Usual Adult Dose for Soft Tissue Sarcoma:
15 mg/kg IV over 60 minutes on Days 1 and 8 of each 21-day cycle until disease progression or unacceptable toxicity; for the first 8 cycles of therapy, this drug is administered with doxorubicin
Premedication: Premedicate with diphenhydramine (25 to 50 mg IV) and dexamethasone (10 to 20 mg IV) prior to olaratumab on Day 1 of cycle 1.
Comments:
-Refer to doxorubicin prescribing information for dosing and dose modifications.
Use: In combination with doxorubicin, for the treatment of adult patients with soft tissue sarcoma (STS) with a histologic subtype for which an anthracycline-containing regimen is appropriate and which is not amenable to curative treatment with radiotherapy or surgery
What other drugs will affect olaratumab?
Other drugs may interact with olaratumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Further information
- Your doctor can provide more information about olaratumab.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.01.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Olaratumab and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/olaratumab.html
