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Generic Name: olaparib (oh LAP a rib)
Medically reviewed by Holevn.org on Dec 30, 2019 – Written by Cerner Multum
What is olaparib?
Olaparib is used to treat ovarian cancer, fallopian tube cancer, or peritoneal cancer in women with a certain abnormal inherited gene.
Olaparib is sometimes given when cancer has come back after treatment with other medications.
Olaparib is also used to treat HER2-negative breast cancer that has spread to other parts of the body before or after prior chemotherapy or hormonal treatment.
Olaparib is sometimes used only if your cancer has a specific genetic marker (an abnormal “BRCA” gene). Your doctor will test you for this gene.
Olaparib may also be used for purposes not listed in this medication guide.
Olaparib affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, weakness, tiredness, trouble breathing, easy bruising or bleeding, blood in your urine or stools, or weight loss.
You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.
Olaparib may also cause serious lung problems. Call your doctor if you have chest pain, wheezing, trouble breathing, or a new or worsening cough.
Before taking this medicine
You should not use olaparib if you are allergic to it.
Tell your doctor if you have ever had:
lung disease, breathing problems; or
Olaparib can harm an unborn baby or cause a miscarriage if the mother or the father is using olaparib.
If you are a woman, do not use this medicine if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Also do not to donate sperm during the 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using olaparib.
Do not breastfeed while using this medicine, and for at least 1 month after your last dose.
How should I take olaparib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Olaparib capsules must not be used as a substitute for olaparib tablets. These two pill forms are not taken in the same dosage amounts. Avoid medication errors by using only the form and strength your doctor prescribes.
Take your doses at regular intervals, about 12 hours apart. You may take olaparib with or without food.
Swallow the capsule or tablet whole. Do not crush, chew, dissolve, break, or open it.
Olaparib affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.
You may also need chest x-rays to be sure this medicine is not causing harmful effects on your lungs. Your cancer treatments may be delayed based on the results.
Store olaparib capsules in the refrigerator, do not freeze. Do not use a capsule that has been exposed to high heat (higher than 104 degrees F).
Store olaparib tablets at room temperature away from moisture and heat. You may also store olaparib capsules at room temperature for up to 3 months.
What happens if I miss a dose?
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
Do not take more than 4 olaparib tablets in one day.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while taking olaparib?
Grapefruit and Seville oranges may interact with olaparib and lead to unwanted side effects. Avoid the use of grapefruit products and orange marmalades.
Olaparib side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:
weakness, feeling very tired;
blood in your urine or stools;
cough, wheezing, shortness of breath;
weight loss; or
low blood cell counts–fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
Your cancer treatments may be delayed if you have certain side effects.
Common side effects may include:
low blood cell counts;
nausea, vomiting, stomach pain, diarrhea, constipation;
heartburn, indigestion, loss of appetite;
dizziness, feeling weak or tired;
headache, back pain, muscle or joint pain;
cold or flu symptoms (stuffy or runny nose, sneezing, cough, sore throat);
mouth sores, altered sense of taste;
abnormal kidney function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect olaparib?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may affect olaparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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The content of Holevn is solely for the purpose of providing information about Thuốc Olaparib and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/olaparib.html