Thuốc Octreotide

29/03/2020

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Holevn Health share articles about :Thuốc Octreotide , side effects – dosage , Thuốc Octreotide what disease treatment.Other noted issues. Please refer to the details below.

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Medically reviewed by Holevn.org. Last updated on Nov 10, 2019.

Commonly used brand name(s)

In the U.S.

SandoSTATIN
SandoSTATIN LAR Depot

Available Dosage Forms:

Solution
Powder for Suspension

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Somatostatin (class)

Uses for octreotide

Octreotide injection is used to treat severe diarrhea and other symptoms that occur with certain intestinal tumors or metastatic carcinoid tumors (tumors that has already spread in the body). It does not cure the tumor but it helps the patient feel more comfortable.

Octreotide injection is also used to treat a condition called acromegaly, which is caused by too much growth hormone in the body. Too much growth hormone produced in adults causes the hands, feet, and parts of the face to become large, thick, and bulky. Other problems, such as arthritis, can also develop. Octreotide works by reducing the amount of growth hormone that is produced by the body.

Octreotide is available only with your doctor’s prescription.

Before using octreotide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For octreotide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to octreotide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of the short-acting form of octreotide injection in the pediatric population. Safety and efficacy have not been demonstrated.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of the long-acting form of octreotide injection in children 6 to 17 years of age. Safety and efficacy have not been established in children younger than 6 years of age.

Geriatric

Although appropriate studies on the relationship of age to the effects of octreotide injection have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of octreotide injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving octreotide injection.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking octreotide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using octreotide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amisulpride
Bepridil
Cisapride
Dronedarone
Levomethadyl
Mesoridazine
Pimozide
Piperaquine
Saquinavir
Sparfloxacin
Terfenadine
Thioridazine
Ziprasidone

Using octreotide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose
Acecainide
Acetophenazine
Ajmaline
Albiglutide
Alogliptin
Amiodarone
Amitriptyline
Amoxapine
Anagrelide
Apomorphine
Aprindine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Azimilide
Azithromycin
Bretylium
Buprenorphine
Buserelin
Canagliflozin
Ceritinib
Chloral Hydrate
Chloroquine
Chlorpromazine
Chlorpropamide
Ciprofloxacin
Citalopram
Clarithromycin
Clofazimine
Clomipramine
Clozapine
Crizotinib
Cyclosporine
Dabrafenib
Dapagliflozin
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Deutetrabenazine
Dibenzepin
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Droperidol
Dulaglutide
Efavirenz
Empagliflozin
Encainide
Encorafenib
Enflurane
Entrectinib
Ertugliflozin
Erythromycin
Escitalopram
Ethopropazine
Exenatide
Fingolimod
Flecainide
Fluconazole
Fluoxetine
Fluphenazine
Foscarnet
Gallium Ga 68 Dotatate
Gallium Ga 68 Dotatoc
Gatifloxacin
Gemifloxacin
Glasdegib
Glimepiride
Glipizide
Glyburide
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Halothane
Histrelin
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibutilide
Iloperidone
Imipramine
Inotuzumab Ozogamicin
Insulin
Insulin Aspart, Recombinant
Insulin Bovine
Insulin Degludec
Insulin Detemir
Insulin Glargine, Recombinant
Insulin Glulisine
Insulin Lispro, Recombinant
Isoflurane
Isradipine
Ivabradine
Ivosidenib
Ketoconazole
Lapatinib
Lefamulin
Lenvatinib
Leuprolide
Levofloxacin
Lidoflazine
Linagliptin
Liraglutide
Lixisenatide
Lofexidine
Lopinavir
Lorcainide
Lumefantrine
Lutetium Lu 177 Dotatate
Macimorelin
Mefloquine
Metformin
Methadone
Methotrimeprazine
Metronidazole
Mifepristone
Miglitol
Moxifloxacin
Nafarelin
Nateglinide
Nilotinib
Norfloxacin
Nortriptyline
Ofloxacin
Ondansetron
Osimertinib
Paliperidone
Panobinostat
Pasireotide
Pazopanib
Pentamidine
Perphenazine
Pimavanserin
Pioglitazone
Pipotiazine
Pirmenol
Pitolisant
Posaconazole
Prajmaline
Pramlintide
Probucol
Procainamide
Prochlorperazine
Promazine
Promethazine
Propafenone
Propiomazine
Protriptyline
Quetiapine
Quinidine
Quinine
Ranolazine
Repaglinide
Ribociclib
Risperidone
Rosiglitazone
Saxagliptin
Sematilide
Sertindole
Sertraline
Sevoflurane
Siponimod
Sitagliptin
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
Spiramycin
Sulfamethoxazole
Sulpiride
Sultopride
Sunitinib
Tacrolimus
Tedisamil
Telavancin
Telithromycin
Tetrabenazine
Thiethylperazine
Tolazamide
Tolbutamide
Toremifene
Trazodone
Triclabendazole
Trifluoperazine
Triflupromazine
Trimeprazine
Trimethoprim
Trimipramine
Triptorelin
Vandetanib
Vardenafil
Vasopressin
Vemurafenib
Vildagliptin
Vinflunine
Voriconazole
Zolmitriptan
Zotepine
Zuclopenthixol

Using octreotide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Pegvisomant
Telotristat Ethyl

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper use of octreotide

A nurse or other trained health professional may give you octreotide. It is given as a shot under your skin or muscle, or as a needle placed into one of your veins. Octreotide may also be given at home to patients who do not need to be in a medical facility. If you are using octreotide at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine.

If you use octreotide at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections.

You might not use all of the medicine in each ampul or vial (glass container). Do not save an opened ampul or vial. If the medicine in the ampul or vial has changed color, or if you see particles in it, do not use it.

Some patients may feel pain, stinging, tingling, or burning sensations at the place where they inject the medicine. Injecting the medicine after it has been warmed to room temperature rather than cold from the refrigerator may reduce the discomfort. However, do not use heat to warm it faster because heat can destroy the medicine.

Put used needles and syringes in a puncture-resistant disposable container or dispose of them as directed by your doctor. Do not reuse needles and syringes.

Dosing

The dose of octreotide will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of octreotide. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For long-acting injection dosage form:
- For treatment of acromegaly:
  - Adults—At first, 20 milligrams (mg) injected into the buttocks once every 4 weeks for 3 months. Your doctor will adjust your dose as needed and tolerated.
  - Children—Use and dose must be determined by your doctor.
- For treatment of severe diarrhea and other symptoms that occur with certain types of intestinal tumors:
  - Adults—At first, 20 milligrams (mg) injected into the muscles once every 4 weeks for 2 months. Your doctor will adjust your dose as needed and tolerated.
  - Children—Use and dose must be determined by your doctor.
For short-acting injection dosage form (solution):
- For treatment of acromegaly:
  - Adults—At first, 50 micrograms (mcg) given as a shot under the skin 3 times a day. Your doctor will adjust your dose as needed.
  - Children—Use and dose must be determined by your doctor.
- For treatment of carcinoid tumors:
  - Adults—At first, 100 to 600 micrograms (mcg) per day, given in 2 to 4 divided doses, injected under the skin for the first 2 weeks. Your doctor will adjust your dose as needed. However, the dose is usually not more than 1500 mcg per day.
  - Children—Use and dose must be determined by your doctor.
- For treatment of severe diarrhea that occurs with certain types of intestinal tumors:
  - Adults—At first, 200 to 300 micrograms (mcg) per day, given in 2 to 4 divided doses, injected under the skin for the first 2 weeks. Your doctor will adjust your dose as needed. However, the dose is usually not more than 450 mcg per day.
  - Children—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of octreotide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of the long-acting form of octreotide, contact your doctor.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may also keep the vials at room temperature, away from heat and direct light, for up to 14 days. Throw away any unused medicine after 14 days.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Precautions while using octreotide

It is very important that your doctor check your progress closely while you are receiving octreotide to make sure that octreotide is working properly. Blood and urine tests may be needed to check for unwanted effects.

Make sure your doctor knows if you are pregnant or planning to become pregnant. You must use an effective form of birth control to keep from getting pregnant. Talk to your doctor about effective birth control.

Octreotide may increase your risk of having gallstones, which may lead to swelling of the gallbladder (cholecystitis), bile ducts (cholangitis), or pancreas (pancreatitis). Check with your doctor right away if you have severe stomach pain with nausea and vomiting, indigestion, fever, chills, pains in the stomach, side, or abdomen, possibly radiating to the back, fast heartbeat, dark urine, bloating, or yellow eyes or skin.

Octreotide may cause your blood sugar levels to rise or fall. Octreotide may cover up signs of hypoglycemia (low blood sugar), such as a change in your pulse rate. If you notice a change in the results of your blood sugar test or urine sugar test, check with your doctor.

Octreotide may increase your risk for heart and blood vessel problems, including hypertension and a slow heartbeat. This may cause chest pain or discomfort, headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high or if your heartbeat is too slow, call your doctor right away.

Octreotide may improve fertility in women and may cause unwanted pregnancies. Talk to your doctor if you have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Octreotide side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Constipation
depressed mood
diarrhea
dizziness
dry skin and hair
fainting
fast, slow, or irregular heartbeat
feeling cold
hair loss
hoarseness or husky voice
loss of appetite
muscle cramps and stiffness
nausea
severe stomach pain with nausea and vomiting
stomach pain
unusual tiredness or weakness
vomiting
weight gain

Less common

Anxiety
bladder pain
bloody or cloudy urine
blurred vision
chills
cold sweats
collection of blood under the skin
confusion
cool, pale skin
deep, dark purple bruise
difficult, burning, or painful urination
dry mouth
flushed, dry skin
frequent urge to urinate
fruit-like breath odor
headache
increased hunger
increased thirst
increased urination
itching, pain, redness, or swelling
loss of consciousness
lower back or side pain
nervousness
nightmares
seizures
shakiness
slurred speech
sweating
swelling
troubled breathing
unexplained weight loss

Rare

Black, tarry stools
bleeding gums
blood in vomit
changes in skin color, pain, tenderness, swelling of the foot or leg
chest pain
cough
coughing up blood
dark urine
decreased urine output
difficulty in breathing or swallowing
difficulty swallowing
dilated neck veins
extreme tiredness or weakness
fast, irregular, pounding, or racing heartbeat or pulse
fever
hives, itching, skin rash
increased menstrual flow or vaginal bleeding
irregular breathing
itching, pain, redness, swelling, tenderness, or warmth on the skin
light-colored stools
nosebleeds
pain in the groin or genitals
pale skin
paleness or cold feeling in the fingertips and toes
paralysis
pounding in the ears
prolonged bleeding from cuts
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red or dark brown urine
severe or continuing stomach pain
sharp back pain just below the ribs
sneezing
sore throat
swelling of the face, fingers, feet, or lower legs
tightness in the chest
tingling or pain in the fingers or toes when exposed to cold temperatures
tremor
troubled breathing with exertion
unusual bleeding or bruising
upper right abdominal pain
yellow eyes and skin

Incidence not known

Bloating
gaseous
indigestion
pains in the stomach, side, or abdomen, possibly radiating to the back
pinpoint red spots on the skin
recurrent fever
severe constipation
stomach fullness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abnormal stool
excess air or gas in the stomach or bowels
full feeling
pain, redness, stinging, swelling, tingling, or burning sensation at the injection site
passing of gas

Less common

Backache
feeling of warmth
hair loss
joint pain
redness of the face, neck, arms and occasionally, upper chest

Rare

Absent, missed, or irregular menstrual periods
change in vision
difficulty in moving
feeling of constant movement of self or surroundings
hearing loss
itching of the vagina or genital area
joint swelling or redness
loss of vision
memory loss
muscle pain
numbness or tingling of the hands, feet, or face
pain during sexual intercourse
sensation of spinning
stopping of menstrual bleeding
swelling of the breasts or breast soreness in both females and males
thick, white vaginal discharge with no odor or with a mild odor
unexpected or excess milk flow from the breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

Medical Disclaimer

The content of Holevn is solely for the purpose of providing information about Thuốc Octreotide and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/octreotide-injection-intramuscular.html

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