Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
Incidence not known
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
Incidence not known
- Hiccups
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
Incidence not known
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
Incidence not known
- Hiccups
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
Incidence not known
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
Incidence not known
- Hiccups
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
Incidence not known
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
Incidence not known
- Hiccups
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
Incidence not known
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
Incidence not known
- Hiccups
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
- Hiccups
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
- Hiccups
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
- Hiccups
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
- Hiccups
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
Incidence not known
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Incidence not known
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
Incidence not known
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Incidence not known
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
Incidence not known
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Incidence not known
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
Incidence not known
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Incidence not known
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html
- Decreased amount of urine
- decreased frequency of urination
- fast, irregular, or troubled breathing
- hives
- increased blood pressure
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
Incidence not known
- Abdominal or stomach pain and tenderness
- agitation
- bloated or full feeling
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- coma
- constipation
- depression
- heartburn or indigestion
- hostility
- irritability
- lethargy
- muscle pain and cramps
- muscle twitching
- pain in the stomach, side, or abdomen, possibly radiating to the back
- pain or discomfort in the arms, jaw, back, or neck
- rectal bleeding
- severe abdominal or stomach cramping or burning
- severe and continuing nausea
- stupor
- swelling of the face, lower legs, ankles, fingers, or hands
- tightness in the chest
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- belching
- blistering, peeling, redness, or swelling of the palms of hands or bottoms of the feet
- cracked lips
- excess air or gas in the stomach or intestines
- feeling of constant movement of self or surroundings
- numbness, pain, tingling, or unusual sensations in the palms of hands or bottoms of feet
- passing gas
- right upper abdominal or stomach pain and fullness
- sensation of spinning
- sleepiness or unusual drowsiness
- sleeplessness
- stomach discomfort, upset, or pain
- trouble sleeping
- unable to sleep
- weight loss
Incidence not known
- Hiccups
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Novaplus Irinotecan Hydrochloride (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/novaplus-irinotecan-hydrochloride.html