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Generic Name: naloxegol (nal OX ee gol)
Medically reviewed by Holevn.org on Aug 30, 2019 – Written by Cerner Multum
What is naloxegol?
Naloxegol blocks certain effects of opioid medication. An opioid is sometimes called a narcotic.
Naloxegol reduces constipation caused by opioid (narcotic) pain medicine used to treat severe chronic pain. Naloxegol works by treating constipation without reducing the pain-relieving effects of the narcotic.
Naloxegol is used in people who have been taking narcotic pain medicine for at least 4 weeks, to treat chronic pain that is not caused by cancer.
Naloxegol may also be used for purposes not listed in this medication guide.
You should not use naloxegol if you have a blockage in your stomach or intestines.
Tell your doctor if you have symptoms of opioid withdrawal, such as anxiety, feeling irritable, sweating, chills, yawning, stomach pain, and diarrhea.
Stop using naloxegol and call your doctor at once if you have severe stomach pain and/or diarrhea (which can lead to serious medical problems).
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Before taking this medicine
You should not use naloxegol if you are allergic to it, or if you have:
a blockage in your stomach or intestines.
Some medicines can cause unwanted or dangerous effects when used with naloxegol. Your doctor may need to change your treatment plan if you also use:
heart medication; or
antiviral medicine to treat hepatitis C or HIV.
Tell your doctor if you have ever had:
a stomach or intestinal disorder (including Crohn’s disease, diverticulitis, or Ogilvie’s syndrome);
stomach cancer, colorectal cancer;
a perforation (a hole or tear) in your esophagus, stomach, or intestines;
liver disease; or
If you use naloxegol while you are pregnant, your baby could have opioid withdrawal symptoms. Tell your doctor if you are pregnant or plan to become pregnant.
Do not breastfeed while taking naloxegol.
Naloxegol is not approved for use by anyone younger than 18 years old.
How should I take naloxegol?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take naloxegol on an empty stomach, at least 1 hour before or 2 hours after your first meal of the day.
If you cannot swallow a naloxegol tablet whole, you may crush the tablet into powder and mix it with 4 ounces of water. Stir and drink this mixture right away. To get the entire dose, add a little more water to the same glass, swirl gently and drink right away.
Naloxegol can also be given through a nasogastric (NG) feeding tube. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Call your doctor if your symptoms do not improve after 3 days of treatment.
After you stop using your pain medication, you should also stop taking naloxegol.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while taking naloxegol?
Do not use any other laxatives that your doctor has not prescribed.
Grapefruit may interact with naloxegol and lead to unwanted side effects. Avoid the use of grapefruit products.
Naloxegol side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using naloxegol and call your doctor at once if you have:
severe stomach pain that will not go away;
severe diarrhea; or
symptoms of narcotic medicine withdrawal–anxiety, feeling irritable, sweating, chills, yawning, stomach pain, diarrhea.
Common side effects may include:
nausea, vomiting, stomach pain;
diarrhea, gas; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Naloxegol dosing information
Usual Adult Dose for Constipation – Drug Induced:
Opioid-Induced Constipation – Chronic:
Initial dose: 25 mg orally once a day
Maintenance dose: 25 mg orally once a day; dose may be reduced to 12.5 mg orally once a day for patients unable to tolerate higher dose
Comments: Prior to initiation, discontinue all maintenance laxative therapy; laxatives can be used as needed for suboptimal response after 3 days.
Use: For the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain.
What other drugs will affect naloxegol?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may interact with naloxegol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 6.01.
The content of Holevn is solely for the purpose of providing information about Thuốc Naloxegol and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/naloxegol.html