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Generic Name: nalbuphine (NAL bue feen)
Medically reviewed by Holevn.org on Oct 17, 2019 – Written by Cerner Multum
What is nalbuphine?
Nalbuphine is an opioid pain medication, sometimes called a narcotic.
Nalbuphine is used to treat moderate to severe pain. It is also used for treating pain just after surgery or childbirth.
Nalbuphine may also be used for purposes not listed in this medication guide.
MISUSE OF nalbuphine CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.
Nalbuphine can slow or stop your breathing, especially when you also use other medicines that can make you sleepy or slow your breathing.
Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Before you receive nalbuphine, tell your doctor about all other medicines you have recently used, especially a sedative or tranquilizer, sleep medicine, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for depression or seizures.
Before taking this medicine
You should not be treated with nalbuphine if you are allergic to it, or if you have:
severe asthma or breathing problems; or
a stomach or bowel obstruction (including paralytic ileus).
Your dose needs may be different if you are already using a similar opioid medicine and are tolerant to it. Before you receive nalbuphine, tell your doctor about all other pain medicines you have recently used.
Tell your doctor if you have ever had:
breathing problems, sleep apnea;
problems with your pancreas or adrenal gland;
a head injury, brain tumor, or seizures;
alcoholism, drug addiction, mental illness;
liver or kidney disease; or
a slow heart rate, or a heart attack.
Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with nalbuphine and cause a serious condition called serotonin syndrome.
Although nalbuphine is sometimes used during labor and delivery, if you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.
Unless you are given nalbuphine during labor or delivery, tell your doctor if you are pregnant before you are treated with this medicine.
Nalbuphine can pass into breast milk and may cause drowsiness or breathing problems in a nursing baby. You should not breast-feed while you are using nalbuphine.
How is nalbuphine given?
Nalbuphine is injected under the skin or into a muscle, or as an infusion into a vein. A healthcare provider will give you this injection.
Nalbuphine is usually given every 3 to 6 hours as needed. Your doctor may occasionally change your dose to make sure you get the best results.
Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
Do not stop using nalbuphine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using nalbuphine.
What happens if I miss a dose?
Because you will receive nalbuphine in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Seek emergency medical attention or call 115. A nalbuphine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.
What should I avoid while receiving nalbuphine?
Do not drink alcohol. Dangerous side effects or death could occur.
Avoid driving or hazardous activity until you know how nalbuphine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Nalbuphine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Tell your caregiver right away if you have:
shallow breathing, breathing that stops during sleep;
a light-headed feeling, like you might pass out;
severe constipation; or
low cortisol levels–nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.
Common side effects may include:
dizziness, spinning sensation;
cold, clammy skin; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Nalbuphine dosing information
Usual Adult Dose for Pain:
Initial dose: 10 mg IV, IM, or subcutaneous every 3 to 6 hours as needed
Maximum single dose: 20 mg
Maximum daily dose: 160 mg
-Usual adult dose is based on a 70 kg individual; dosage should be adjusted according to the severity of pain, physical status, and concomitant medications.
-Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy and with each dose increase.
-Because of the risks of addiction, abuse, and misuse, reserve use to patients for whom alternative treatment options have not been tolerated, or are not expected to be tolerated; or have not provided adequate analgesia or are not expected to provide adequate analgesia.
Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
Usual Adult Dose for Anesthesia:
Supplement to balanced anesthesia:
Induction dose: 0.3 to 3 mg/kg IV over 10 to 15 minutes
Maintenance dose: 0.25 to 0.5 mg/kg in single IV administrations as required
-This drug should be administered as a supplement to general anesthesia by persons specifically trained in the use of IV anesthetics and management of the respiratory effects of potent opioids; naloxone, resuscitative and intubation equipment and oxygen should be readily available.
Use: As a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.
What other drugs will affect nalbuphine?
Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (“water pill”);
medicines for motion sickness, irritable bowel syndrome, or overactive bladder;
other narcotic medications–opioid pain medicine or prescription cough medicine;
a sedative like Valium–diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;
drugs that make you sleepy or slow your breathing–a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness;
drugs that affect serotonin levels in your body–a stimulant, or medicine for depression, Parkinson’s disease, migraine headaches, serious infections, or nausea and vomiting.
This list is not complete. Other drugs may affect nalbuphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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The content of Holevn is solely for the purpose of providing information about Thuốc Nalbuphine and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/nalbuphine.html