Thuốc Mechlorethamine (Intravenous)

0
374
Thuốc Mechlorethamine (Intravenous)
Thuốc Mechlorethamine (Intravenous)

Holevn Health share articles about :Thuốc Mechlorethamine (Intravenous)  , side effects – dosage , Thuốc Mechlorethamine (Intravenous) what disease treatment.Other noted issues. Please refer to the details below.

me-klor-ETH-a-meen

Intravenous route(Powder for Solution)

This drug is highly toxic and both powder and solution must be handled and administered with care. Inhalation of dust or vapors and contact with skin, eyes, or mucous membranes must be avoided. Avoid exposure during pregnancy. Due to the toxic properties of mechlorethamine (eg, corrosivity, carcinogenicity, mutagenicity, teratogenicity), special handling procedures should be reviewed prior to handling and followed diligently. Extravasation of the drug into subcutaneous tissues results in a painful inflammation and if leakage of drug is obvious, prompt infiltration of the area with sterile isotonic sodium thiosulfate and application of an ice compress may minimize the local reaction .

Medically reviewed by Holevn.org. Last updated on Jul 2, 2019.

Commonly used brand name(s)

In the U.S.

  • Mustargen

Pharmacologic Class: Alkylating Agent

Chemical Class: Nitrogen Mustard

Uses for mechlorethamine

Mechlorethamine belongs to the group of medicines called alkylating agents. It is used to treat some kinds of cancer as well as some noncancerous conditions.

Mechlorethamine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by mechlorethamine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with mechlorethamine, you and your doctor should talk about the good mechlorethamine will do as well as the risks of using it.

Mechlorethamine is to be administered only by or under the immediate supervision of your doctor.

Before using mechlorethamine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mechlorethamine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to mechlorethamine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of mechlorethamine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of mechlorethamine in the elderly with use in other age groups.

Pregnancy

Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking mechlorethamine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using mechlorethamine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Varicella Virus Vaccine, Live
  • Zoster Vaccine, Live

Using mechlorethamine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Cholera Vaccine, Live
  • Dengue Tetravalent Vaccine, Live
  • Influenza Virus Vaccine, Live
  • Poliovirus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine
  • Warfarin
  • Yellow Fever Vaccine

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of mechlorethamine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Chickenpox (including recent exposure) or
  • Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body
  • Gout or
  • Kidney stones—Mechlorethamine may increase levels of uric acid in the body, which can cause gout and kidney stones
  • Infection—Mechlorethamine may decrease your body’s ability to fight infection

Proper use of mechlorethamine

Mechlorethamine is sometimes given together with certain other medicines. If you are using a combination of medicines, it is important that you receive each one at the proper time. If you are taking some of these medicines by mouth, ask your health care professional to help you plan a way to take them at the right times.

While you are using mechlorethamine, your doctor may want you to drink extra fluids so that you will pass more urine. This will help prevent kidney problems and keep your kidneys working well.

Mechlorethamine often causes nausea and vomiting, which usually last only 8 to 24 hours. It is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects.

Dosing

The dose of mechlorethamine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of mechlorethamine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Precautions while using mechlorethamine

It is very important that your doctor check your progress at regular visits to make sure that mechlorethamine is working properly and to check for unwanted effects.

While you are being treated with mechlorethamine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor’s approval. Mechlorethamine may lower your body’s resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Mechlorethamine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
  • Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin.
  • Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
  • Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
  • Avoid contact sports or other situations where bruising or injury could occur.

If mechlorethamine accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the health care professional right away if you notice redness, pain, or swelling at the place of injection.

Mechlorethamine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way cancer medicines act on the body, there is a chance that they might cause other effects that may not occur until months or years after these medicines are used. These delayed effects may include certain types of cancer. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur:

Less common

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • pain or redness at place of injection
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Rare

  • Shortness of breath, itching, or wheezing

Check with your doctor as soon as possible if any of the following side effects occur:

More common

  • Missing menstrual periods
  • painful rash

Less common

  • Dizziness
  • joint pain
  • loss of hearing
  • ringing in ears
  • swelling of feet or lower legs

Rare

  • Numbness, tingling, or burning of fingers, toes, or face
  • sores in mouth and on lips
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Nausea and vomiting (usually lasts only 8 to 24 hours)

Less common

  • Confusion
  • diarrhea
  • drowsiness
  • headache
  • loss of appetite
  • metallic taste
  • weakness

Mechlorethamine may cause a temporary loss of hair in some people. After treatment with mechlorethamine has ended, normal hair growth should return.

After you stop using mechlorethamine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Mechlorethamine (Intravenous)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/mechlorethamine-intravenous.html

Đánh giá 5* bài viết này

LEAVE A REPLY

Please enter your comment!
Please enter your name here