Thuốc Letrozole and ribociclib

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Thuốc Letrozole and ribociclib
Thuốc Letrozole and ribociclib
  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

  • liver problems–loss of appetite, right-sided stomach pain, tiredness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes); or

  • low white blood cell counts–fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, vomiting, diarrhea, constipation;

  • headache;

  • feeling tired;

  • abnormal liver function tests;

  • back pain; or

  • hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Letrozole and ribociclib dosing information

Usual Adult Dose for Breast Cancer:

Letrozole: 2.5 mg orally once a day throughout the 28-day cycle
Ribociclib: 600 mg orally once a day for 21 consecutive days followed by 7 days off for a 28-day cycle

Use: Initial endocrine-based therapy for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer

What other drugs will affect letrozole and ribociclib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Letrozole and ribociclib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect letrozole and ribociclib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

The content of Holevn is solely for the purpose of providing information about Thuốc Letrozole and ribociclib  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/mtm/letrozole-and-ribociclib.html

Tell your doctor if you have any signs of infection, such as fever or chills, or if you have ever had:

  • heart disease, heart failure;

  • a heart attack;

  • heart rhythm problems, including slow heartbeats;

  • long QT syndrome;

  • low levels of calcium, phosphorus, potassium, or magnesium in your blood; or

  • liver or kidney disease.

If you have not gone through menopause, you may need an additional hormonal medication while taking letrozole and ribociclib. Tell your doctor if you have begun having symptoms of menopause such as irregular menstrual periods, hot flashes, night sweats, sleep problems, or vaginal dryness.

You may need to have a negative pregnancy test before starting this treatment.

Letrozole and ribociclib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 weeks after your last dose. Tell your doctor right away if you become pregnant.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important for women to use birth control to prevent pregnancy because letrozole and ribociclib may harm the baby if a pregnancy does occur.

You should not breast-feed while using this medicine and for at least 3 weeks after your last dose.

How should I take letrozole and ribociclib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

It is best to take this medicine in the morning, but take it at the same time each day. You may take letrozole and ribociclib with or without food.

Letrozole and ribociclib is given in a 28-day treatment cycle. On days 1 through 21, you will take both ribociclib and letrozole together at the same time each day. During the last 7 days you will take only letrozole each day.

Your doctor may occasionally change the number of tablets in your dose. Follow all dosing instructions very carefully.

Swallow each tablet whole and do not crush, chew, or break it. Do not take any tablet that is broken or cracked.

If you vomit shortly after taking a tablet, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

This medicine can cause a serious heart rhythm problem. Call your doctor at once if you have a fast or pounding heartbeats and severe dizziness.

You will need frequent medical tests while taking letrozole and ribociclib. Your cancer treatments may be delayed based on the results of these tests.

Do not change your dose or stop taking this medicine without your doctor’s advice.

Store each medicine in its original container at room temperature, away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call 115.

What should I avoid while taking letrozole and ribociclib?

Grapefruit may interact with letrozole and ribociclib and lead to unwanted side effects. Avoid the use of grapefruit products.

Letrozole and ribociclib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

  • liver problems–loss of appetite, right-sided stomach pain, tiredness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes); or

  • low white blood cell counts–fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, vomiting, diarrhea, constipation;

  • headache;

  • feeling tired;

  • abnormal liver function tests;

  • back pain; or

  • hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Letrozole and ribociclib dosing information

Usual Adult Dose for Breast Cancer:

Letrozole: 2.5 mg orally once a day throughout the 28-day cycle
Ribociclib: 600 mg orally once a day for 21 consecutive days followed by 7 days off for a 28-day cycle

Use: Initial endocrine-based therapy for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer

What other drugs will affect letrozole and ribociclib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Letrozole and ribociclib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect letrozole and ribociclib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

The content of Holevn is solely for the purpose of providing information about Thuốc Letrozole and ribociclib  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/mtm/letrozole-and-ribociclib.html

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