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Life-threatening anaphylactic reactions have been observed in some patients during laronidase infusions. Appropriate medical support should be readily available when laronidase is administered. Patients with compromised respiratory function or acute respiratory disease may be at risk of serious acute exacerbation of their respiratory condition due to infusion reactions and need additional monitoring .
Medically reviewed by Holevn.org. Last updated on Aug 5, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Endocrine-Metabolic Agent
Pharmacologic Class: Enzyme
Uses for laronidase
Laronidase is used to treat Hurler and Hurler-Schele syndrome forms of mucopolysaccharidosis (MPS I) disease caused by the lack of a certain enzyme called α-L-iduronidasein the body.
Laronidase is available only with your doctor’s prescription.
Before using laronidase
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For laronidase, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to laronidase or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of laronidase in children younger than 5 years of age. Safety and efficacy have not been established .
Appropriate studies on the relationship of age to the effects of laronidase have not been performed in the geriatric population .
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of laronidase. Make sure you tell your doctor if you have any other medical problems, especially:
- Breathing problems or
- Lung disease—Use with caution. May make these conditions worse .
Proper use of laronidase
A nurse or other trained health professional will give you laronidase. Laronidase is given through a needle placed in one of your veins .
You may also be given other medicines to keep you from having a fever or to prevent allergic reactions before you receive the injection .
Precautions while using laronidase
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it .
Laronidase may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; swelling of the face, tongue, and throat; lightheadedness; slow or irregular heartbeat; shortness of breath; trouble breathing; or chest pain or tightness after you get the injection .
Laronidase side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Abdominal or stomach pain
- accumulation of pus
- back pain
- black, tarry stools
- bleeding gums
- blood in urine or stools
- blurred vision
- chest pain
- chest tightness
- clay-colored stools
- dark urine
- facial swelling
- fast, pounding, or irregular heartbeat or pulse
- hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
- lightheadedness when getting up from a lying or sitting position suddenly
- loss of appetite
- nausea or vomiting
- pale skin
- pinpoint red spots on skin
- shortness of breath
- skin rash
- swollen, red, or tender area of infection
- trouble breathing
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
- difficulty breathing
- itching skin
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- noisy breathing
- redness of skin
- tightness in chest
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bleeding, blistering, burning, coldness, or discoloration of skin
- body aches or pain
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- decreased vision
- difficulty in moving
- ear congestion
- feeling of pressure
- loss of voice
- muscle pain or stiffness
- nasal congestion
- overactive reflexes
- pain in joints
- runny nose
- sore throat
- swelling of legs and feet
- swelling or puffiness of face
- varicose or spider veins
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
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The content of Holevn is solely for the purpose of providing information about Thuốc Laronidase (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/laronidase-intravenous.html