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lan-a-DEL-ue-mab – flyo
Medically reviewed by Holevn.org. Last updated on Jul 18, 2019.
Commonly used brand name(s)
In the U.S.
- Takhzyro
Available Dosage Forms:
- Solution
Therapeutic Class: Immune Modulator
Pharmacologic Class: Lanadelumab
Uses for lanadelumab-flyo
Lanadelumab-flyo injection is used to prevent hereditary angioedema (HAE) attacks. HAE is a rare disease that causes swelling of the face, hands, feet, throat, stomach, bowels, or genitals.
Lanadelumab-flyo is available only with your doctor’s prescription.
Before using lanadelumab-flyo
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lanadelumab-flyo, the following should be considered:
Allergies
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of lanadelumab-flyo injection in children younger than 12 years of age. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lanadelumab-flyo injection in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Proper use of lanadelumab-flyo
A nurse or other trained health professional will give you lanadelumab-flyo. It is given as a shot under your skin, usually in the stomach, thighs, or upper arms. You or your caregiver may be trained to prepare and inject the medicine at home. Be sure that you understand how to use the medicine.
Lanadelumab-flyo comes with a patient information leaflet and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.
You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems. Do not inject into skin areas that are swollen, painful, bruised, or less than 2 inches away from scars or your belly button.
Check the liquid in the vial. It should be colorless or slightly yellow. Do not use lanadelumab-flyo if it is cloudy, discolored, or if it has particles in it. Do not shake.
Use a new needle and syringe each time you inject your medicine.
Dosing
The dose of lanadelumab-flyo will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of lanadelumab-flyo. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For injection dosage form (solution):
- For hereditary angioedema:
- Adults and children 12 years of age and older—The usual dose is 300 milligrams (mg) injected under the skin every 2 weeks. 300 mg every 4 weeks may also be given if the patient is well controlled (attack free) for more than 6 months.
- Children younger than 12 years of age—Use and dose must be determined by your doctor.
- For hereditary angioedema:
Missed dose
Call your doctor or pharmacist for instructions.
Storage
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Store unopened vials in the original carton in the refrigerator. Do not freeze.
Use lanadelumab-flyo within 2 hours after preparing it at room temperature. You may also refrigerate the prepared dosing syringe and use it within 8 hours. Allow it to warm to room temperature first for 15 minutes before you use it.
Throw away used needles in a hard, closed container which the needles cannot poke through. Keep this container away from children and pets.
Precautions while using lanadelumab-flyo
It is very important that your doctor check your or your child’s progress at regular visits to make sure that the medicine is working properly and to check for unwanted effects.
Make sure to use lanadelumab-flyo regularly. HAE attacks are life-threatening and require immediate medical attention. Carefully follow all of your doctor’s instructions.
Lanadelumab-flyo may cause serious allergic reactions, which can be life-threatening and require immediate medical attention. Call your doctor or nurse right away if you or your child have a rash, itching, hives, hoarseness, chest tightness, lightheadedness, dizziness or fainting, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using lanadelumab-flyo.
Make sure any doctor or dentist who treats you knows that you are using lanadelumab-flyo. Lanadelumab-flyo may affect the results of certain medical tests.
Lanadelumab-flyo side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
- Rash
Less common
- Fast heartbeat
- fever
- hives, itching
- hoarseness
- irritation
- joint pain, stiffness, or swelling
- redness of the skin
- swelling of the eyelids, face, lips, hands, or feet
- tightness in the chest
- troubled breathing or swallowing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- body aches or pain
- chills
- cough
- difficulty in moving
- dizziness
- ear congestion
- headache
- loss of voice
- muscle ache, cramps, pain, or stiffness
- nasal congestion
- runny nose
- sneezing
- sore throat
- unusual tiredness or weakness
Less common
- Diarrhea
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
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Related questions
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Lanadelumab-flyo (Subcutaneous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/lanadelumab-flyo-subcutaneous.html
