Holevn Health share articles about :Thuốc Lady’s Mantle , side effects – dosage , Thuốc Lady’s Mantle what disease treatment.Other noted issues. Please refer to the details below.
Scientific Name(s): Alchemilla mollis., Alchemilla vulgaris., Alchemilla xanthochlora.
Common Name(s): Alchemilla, Common lady’s mantle, Ladder brake, Lady’s mantle, Lion’s foot
Medically reviewed by Holevn.org. Last updated on Aug 22, 2019.
Lady’s mantle has been traditionally used both topically and internally as a treatment for wounds, GI complaints, and female ailments (eg, menstrual or menopausal complaints); however, clinical studies are lacking to support these uses. Animal studies do not support the use of lady’s mantle in diabetes, and limited studies of use in wound healing have been conducted.
Clinical studies are lacking to support specific dosing recommendations for lady’s mantle. A gel made from the leaves has been used topically for mouth ulcers. Oral dosages of 5 to 10 g of the herb in 1 L of water daily, or of 2 to 4 mL of the liquid herb extract have been traditionally used for the treatment of diarrhea.
Contraindications have not been identified.
Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.
None well documented.
None known with use at low doses.
- Rosaceae (rose)
Alchemilla, an aggregate of species collectively referred to as “lady’s mantle,” is native to cool, temperate regions of Europe and Asia, with some species cultivated in North America, and grows in meadows, woodland clearings, and pastures. It is a perennial herb that grows up to 40 cm in height and consists of a short rhizome carrying ascending or sprawling stems and large (up to 8 cm in width) circular or kidney-shaped grey-green leaves at the base. The main ribs of the leaf protrude to the lower face and have small teeth at their tips. The inflorescence is a compound terminal cyme of dense clusters of small, yellow-green flowers, with sepals occurring in 2 rings of 4 without petals. The fruit is of the achene type (formed from one carpel). The entire plant is covered in fine, soft, short hairs.1, 2, 3 A synonym is Alchemilla vulgaris.
In the Middle Ages, alchemists used rain water or dew collected in the leaf center for its purported magical and medicinal powers, a custom derived from the plant’s generic name “alchemilla,” which is from the Arabic word “alkimiya,” meaning “universal cure for disease.” The plant has long been associated with the Virgin Mary due to the shape of its leaf lobes, which resemble the edges of a mantle, and was one of several herbal plants used in wreaths during Corpus Christi celebrations. Traditional uses for lady’s mantle include as a mild astringent, anti-inflammatory, antidiarrheal, diuretic, menstrual cycle regulator, treatment for digestive disorders, and relaxant for muscular spasms. Externally, lady’s mantle has been widely used in bath preparations, wound healing, skin bruises, and as an herbal cosmetic.2, 3, 4, 5
Lady’s mantle, similar to most members of the Rosaceae family, contains flavonoids and phenolic acids, which may account for its antioxidant activity.6, 7, 8, 9 The flavonoids quercetin, rutin, and kaempferol have been identified, as well as the phenols gallic acid and caffeic acid, although concentrations among species vary.3, 5, 8, 9, 10, 11 The presence of tannins (elagitannins such as pedunculagin and alchemillin) at concentrations of 6% to 8% has also been described.2, 3 Aldehydes, alcohols, terpenes, esters, acids, and hydrocarbons have been identified in the essential oil.12
Uses and Pharmacology
In one study examining the vascular effects of methanol and aqueous extracts of A. vulgaris in rats, the methanol extract was high in quercetin and had a relaxant effect on aortic tissue, while the aqueous extract was higher in gallic acid content and resulted in enhanced contractility.11, 13 Oral administration of the methanol extract had a hypotensive effect.13
No clinical data exist regarding the use of lady’s mantle for hypertension or other cardiovascular diseases.
Despite the plant’s purported use in diabetes, lady’s mantle showed no effect on hyperphagia, polydipsia, body weight loss, hyperglycemia, or hyperinsulinemia in a study involving mice with streptozotocin-induced diabetes.14
No clinical data exist regarding the use of lady’s mantle in diabetes.
Inhibition of the activity of the proteolytic enzymes elastase, trypsin, and alpha-chymotrypsin has been attributed to the tannin content of lady’s mantle extracts.3, 15, 16 Promitotic activity in epithelial cells and myofibroblasts was demonstrated in rats administered A. vulgaris extract.17 In a study of rats with induced endometrial adhesions, A. mollis aerial plant parts administered daily by gavage resulted in modulation of inflammatory cytokines (including tumor necrosis factor, endothelial growth factor, and interleukin 6).18
In an open-label study in patients with recurrent aphthous ulcers, topical applications of A. vulgaris gel resulted in faster self-reported healing of ulcers.19, 20
In vitro, lady’s mantle leaf extract demonstrated some activity against human bacterial and fungal pathogens, including Helicobacter pylori.9, 21 An inhibitory effect against influenza viruses was also observed in vitro.22 In a rat model of endometriosis, A. mollis extract significantly reduced adhesion scores and reduced mean endometrioma volume (from 101.35 to 11.87 mm3).18
A. vulgaris administered as part of a mixture of 4 plants was studied for its potential weight loss properties in humans. Significant and progressive weight reductions were observed over 3 months, with higher levels of weight loss observed in subjects with body mass index (BMI) 25 to 30 kg/m2 compared to those with BMI greater than 30 kg/m2.23
Clinical studies are lacking to provide dosing guidelines. Lady’s mantle has been used topically as a 3% gel for oral, nonherpetiform ulcers.19, 20
Oral dosages of 5 to 10 g of the herb in 1 L of water daily,3 or of 2 to 4 mL of the liquid herb extract have been traditionally used for the treatment of diarrhea.24
Pregnancy / Lactation
Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.24
None well documented.
Information regarding adverse reactions with the use of lady’s mantle is limited.3, 24
Information regarding toxicity of lady’s mantle is limited. No morphological changes or cytotoxicity were observed in an in vitro study.17 The tannin content of lady’s mantle extracts may be toxic at higher than usual doses.24 In another study, the quercetin content of lady’s mantle was too low to be mutagenic.25
1. Alchemilla mollis (Buser) Rothm. USDA, NRCS. 2016. The PLANTS Database (http://plants.usda.gov, 2016). National Plant Data Team, Greensboro, NC 27401-4901 USA. Accessed July 28, 2016.2. Bisset N, ed. Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis. Stuttgart, Germany: CRC Press; 1994.3. Ghedira K, Goetz P, Le Jeune R. Alchemilla vulgaris L.: Alchémille (Rosaceae). Phytotherapie. 2012;10(4):263-266.4. Luczaj LJ. A relic of medieval folklore: Corpus Christi Octave herbal wreaths in Poland and their relationship with the local pharmacopoeia. J Ethnopharmacol. 2012;142(1):228-240.225757055. Smolyakova IM, Andreeva VY, Kalinkina GI, Avdeenko SN, Shchetinin PP. Development of extraction techniques and standardization methods for a common lady’s mantle (Alchemilla vulgaris) extract. Pharm Chem J. 2012;45(11):675-678.6. Olafsdottir ES, Omarsdottir S, Jaroszewski JW. Constituents of three Icelandic Alchemilla species. Biochem Syst Ecol. 2001;29(9):959-962.114452967. Condrat D, Crisan F, Szabo MR, Lupea AX. Flavonoids in angiosprmatophyta and spermatophyta species and their antioxidant activity. Rev Chim. 2009;60(11):1129-1134.8. Condrat D, Mosoarca C, Zamfir AD, Crisan F, Szabo MR, Lupea AX. Qualitative and quantitative analysis of gallic acid in Alchemilla vulgaris, Allium ursinum, Acorus calamus and Solidago virga-aurea by chip-electrospray ionization mass spectrometry and high performance liquid chromatography. Cent Eur J Chem. 2010;8(3):530-535.9. Denev P, Kratchanova M, Ciz M, et al. Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts. Acta Biochim Pol. 2014;61(2):359-367.2494513510. Fraisse D, Heitz A, Carnat A, Carnat AP, Lamaison JL. Quercetin 3-arabinopyranoside, a major flavonoid compound from Alchemilla xanthochlora. Fitoterapia. 2000;71(4):463-464.1092502911. Takir S, Sezgi B, Süzgeç-Selçuk S, et al. Endothelium-dependent vasorelaxant effect of Alchemilla vulgaris methanol extract: a comparison with the aqueous extract in rat aorta. Nat Prod Res. 2014;28(23):2182-2185.2493875512. Falchero L, Coppa M, Fossi A, Lombardi G, Ramella D, Tava A. Essential oil composition of lady’s mantle (Alchemilla xanthochlora Rothm.) growing wild in Alpine pastures. Nat Prod Res. 2009;23(15):1367-1372.1980990713. Takir S, Altun IH, Sezgi B, Süzgeç-Selçuk S, Mat A, Uydeş-Doğan BS. Vasorelaxant and blood pressure lowering effects of Alchemilla vulgaris: A comparative study of methanol and aqueous extracts. Pharmacogn Mag. 2015;11(41):163-169.2570922814. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia. 1990;33(8):462-464.221011815. Jonadet M, Meunier MT, Villie F, Bastide JP, Lamaison JL. Flavonoids extracted from Ribes nigrum L. and Alchemilla vulgaris L.: 1. In vitro inhibitory activities on elastase, trypsin and chymotrypsin. 2. Angioprotective activities compared in vivo [in French]. J Pharmacol. 1986;17(1):21-27.363565316. Lamaison JL, Carnat A, Petitjean-Freytet C. Tannin content and inhibiting activity of elastase in Rosaceae [in French]. Ann Pharm Fr. 1990;48(6):335-340.213176617. Shrivastava R, Cucuat N, John GW. Effects of Alchemilla vulgaris and glycerine on epithelial and myofibroblast cell growth and cutaneous lesion healing in rats. Phytother Res. 2007;21(4):369-373.1723616918. Küpeli Akkol E, Demirel MA, Bahadir Acikara O, et al. Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model. Arch Gynecol Obstet. 2015;292(3):619-628.2570065919. Shrivastava R, John GW. Treatment of aphthous stomatitis with topical Alchemilla vulgaris in glycerine. Clin Drug Investig. 2006;26(10):567-573.1716329020. Abascal K, Yarnell E. Treatments for recurrent aphthous stomatitis. Altern Complement Ther. 2010;16(2):100-106.21. Krivokuća M, Niketić M, Milenković M, et al. Anti-Helicobacter pylori activity of four Alchemilla species (Rosaceae). Nat Prod Commun. 2015;10(8):1369-1371.2643411922. Makau JN, Watanabe K, Kobayashi N. Anti-influenza activity of Alchemilla mollis extract: possible virucidal activity against influenza virus particles. Drug Discov Ther. 2013;7(5):189-195.2427038323. Said O, Saad B, Fulder S, Khalil K, Kassis E. Weight loss in animals and humans treated with “Weighlevel”, a combination of four medicinal plants used in traditional Arabic and Islamic medicine. Evid Based Complement Alternat Med. 2011;2011:874538.1895268824. Duke J, Bogenschutz-Godwin M, duCellier J, Duke P. Handbook of Medicinal Herbs. 2nd ed. Boca Raton, FL: CRC Press; 2002.25. Schimmer O, Häfele F, Krüger A. The mutagenic potencies of plant extracts containing quercetin in Salmonella typhimurium TA98 and TA100. Mutat Res. 1988;206(2):201-208.3050500
This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.
This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.
Copyright © 2019 Wolters Kluwer Health
The content of Holevn is solely for the purpose of providing information about Thuốc Lady’s Mantle and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/npp/lady-s-mantle.html