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la-KOE-sa-mide
Medically reviewed by Holevn.org. Last updated on Mar 19, 2019.
Commonly used brand name(s)
In the U.S.
- Vimpat
Available Dosage Forms:
- Solution
Therapeutic Class: Anticonvulsant
Uses for lacosamide
Lacosamide injection is used to control partial seizures (convulsions) in the treatment of epilepsy. It acts on the central nervous system (CNS) to reduce the number and severity of seizures.
Lacosamide is to be given only by or under the direct supervision of your doctor.
Before using lacosamide
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lacosamide, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to lacosamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of lacosamide injection in children younger than 17 years of age. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lacosamide injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving lacosamide injection.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving lacosamide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using lacosamide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acebutolol
- Amiodarone
- Amitriptyline
- Amlodipine
- Aranidipine
- Atazanavir
- Atenolol
- Bepridil
- Betaxolol
- Bisoprolol
- Calcifediol
- Carteolol
- Carvedilol
- Celiprolol
- Chlordiazepoxide
- Cilnidipine
- Clevidipine
- Dalfampridine
- Diltiazem
- Disopyramide
- Dofetilide
- Dolasetron
- Dronedarone
- Encainide
- Eslicarbazepine Acetate
- Esmolol
- Felodipine
- Flecainide
- Ibutilide
- Isradipine
- Labetalol
- Levobunolol
- Lidocaine
- Lopinavir
- Manidipine
- Metipranolol
- Metoprolol
- Mexiletine
- Nadolol
- Nebivolol
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitrendipine
- Orlistat
- Oxcarbazepine
- Oxprenolol
- Penbutolol
- Phenytoin
- Pindolol
- Practolol
- Procainamide
- Propafenone
- Propranolol
- Quinidine
- Quinine
- Ritonavir
- Saquinavir
- Sotalol
- Timolol
- Tocainide
- Verapamil
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of lacosamide. Make sure you tell your doctor if you have any other medical problems, especially:
- Brugada syndrome (genetic disease) or
- Depression, history of or
- Drug or alcohol abuse or dependence, history of or
- Heart attack or
- Heart block or
- Heart disease (eg, heart failure, myocardial ischemia) or
- Heart failure or
- Heart rhythm problems (eg, prolonged PR interval) or
- Mental illness, history of or
- Sick sinus syndrome (type of abnormal heart rhythm), without pacemaker—Use with caution. May make these conditions worse.
- Diabetic neuropathy or
- Heart or blood vessel disease—May increase risk for more serious side effects.
- Kidney disease, severe or
- Liver disease, mild to moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Liver disease, severe—Should not be used in patients with this condition.
Proper use of lacosamide
A nurse or other trained health professional will give you lacosamide in a hospital. It is given through a needle placed into one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for at least 15 to 60 minutes.
Lacosamide should come with a Medication Guide. It is very important that you read and understand this information. Ask your doctor if you have any questions.
Your doctor may give you a few doses of lacosamide until your condition improves, and then you may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.
Precautions while using lacosamide
Your doctor will check your progress closely while you are receiving lacosamide. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.. Blood and urine tests may be needed to check for unwanted effects.
If you develop any unusual or strange thoughts and behavior while receiving lacosamide injection, be sure to discuss it with your doctor. Some changes that have occurred in people receiving lacosamide are like those seen in people who drink too much alcohol. Other changes might be confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.
Lacosamide may cause blurred vision, double vision, clumsiness, unsteadiness, dizziness, drowsiness, sleepiness, or trouble with thinking. Do not drive or do anything else that could be dangerous until you know how lacosamide affects you. If these side effects are especially bothersome, check with your doctor.
Lacosamide can cause changes in heart rhythms, such as a condition called PR prolongation. It may change the way your heart beats and cause lightheadedness, fainting, or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, slow, or irregular heartbeats.
Lacosamide injection may cause a condition called drug reaction with eosinophilia and systemic symptoms (DRESS), which is a serious allergic reaction affecting multiple body organs (eg, liver or kidney). Check with your doctor right away if you have the following symptoms: fever, dark urine, headache, rash, stomach pain, swollen, painful, or tender lymph glands in the neck, armpit, or groin, unusual tiredness, or yellow eyes or skin.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Lacosamide side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
- Dizziness
- shakiness and unsteady walk
- sleepiness or unusual drowsiness
- trembling or shaking of the hands or feet
- unsteadiness, trembling, or other problems with muscle control or coordination
Less common
- Being forgetful
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- discouragement
- feeling sad or empty
- irritability
- itching skin
- lack of appetite
- loss of balance control
- loss of interest or pleasure
- mood or mental changes
- tearing of the skin
- tiredness
- trouble concentrating
- trouble with sleeping
- trouble with walking
Rare
- Chest pain or discomfort
- flushing or redness of the skin
- lightheadedness, dizziness, or fainting
- slow or irregular heartbeat
- unusual tiredness
- unusually warm skin
Incidence not known
- Abnormal or decreased touch sensation
- black, tarry stools
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- changes in patterns and rhythms of speech
- chills
- continuing ringing or buzzing or other unexplained noise in the ears
- cough
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling drunk
- fever
- hearing loss
- lower back or side pain
- painful or difficult urination
- pale skin
- slurred speech
- sore throat
- trouble performing routine tasks
- trouble with balance
- trouble with speaking
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Blurred vision
- double vision
- headache
- nausea
- seeing double
- vomiting
Less common
- Diarrhea
- feeling of constant movement of self or surroundings
- lack or loss of strength
- sensation of spinning
- uncontrolled eye movements
Incidence not known
- Belching
- difficulty having a bowel movement
- dry mouth
- heartburn
- indigestion
- muscle spasms
- stomach discomfort, upset, or pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
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Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Lacosamide (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/lacosamide-intravenous.html
