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Scientific Name(s): Polygonum cuspidatum Siebold & Zucc.
Common Name(s): Fleeceflower, Huzhang, Japanese bamboo, Japanese knotweed, Mexican bamboo
Medically reviewed by Holevn.org. Last updated on Dec 25, 2019.
Huzhang (Japanese Knotweed) has been used in traditional Chinese medicine as well as in Japan and Korea for many years. Although used for various applications, few clinical studies validate claims and guidance regarding dosing or safety is limited.
For information specific to the activity of resveratrol, see Resveratrol.
Clinical evidence on which to base dosing guidelines is limited. One clinical study used an oral extract of P. cuspidatum 200 mg containing resveratrol 40 mg over 6 weeks for anti-inflammatory effect.
Do not use. Avoid use during lactation because information is lacking.
None well documented.
Clinical evidence is limited.
Information is limited.
- Polygonaceae (Buckwheat)
P. cuspidatum is a perennial plant growing to approximately 2 m tall. It has mucous hollow stems with reddish purple spots and ovate/elliptical deciduous leaves (5 to 12 cm by 4 to 9 cm). The male and female flowers occur on separate plants, and the fruits are black/brown, shiny, and ovoid. The plant is native to eastern Asia, including Japan, China, and Korea. It is cultivated in those countries and in the US, and is propagated by seeds or the root. Synonyms include Pleuropterus cuspidatus (Siebold & Zucc.) Moldenke, Fallopia japonica (Houtt.) Ronse Decr., Pleuropterus zuccarinii (Small) Small, Polygonum cuspidatum Siebold & Zucc. var. compactum (Hook. f.) L.H. Bailey, and Reynoutria japonica Houtt.
Because of the plant’s spreading rhizomes, P. cuspidatum is grown commercially as a major source for resveratrol production (see Resveratrol monograph), while also being considered a noxious, invasive class B or C weed in certain US states.Chen 2013, Peng 2013, USDA 2013
At least 100 prescriptions using the root exist in the Pharmacopoeia of the People’s Republic of China to treat bronchitis and cough, gonorrhea, inflammation, infection, jaundice, hyperlipidemia and hypertension, menopausal symptoms and amenorrhea, and skin burns. The root is used extensively in traditional medicine in China, Japan, and Korea, and the young plant parts are eaten as a vegetable. P. cuspidatum is a primary source of resveratrol, which is widely available in the United States as a botanical dietary supplement.Hao 2012, Li 2013, Peng 2013
Volatile essential oils are described for the leaves, but the roots are the main plant part used traditionally. Major constituent chemicals include quinines (eg, anthraquinone, naphthoquinone, phylloquinone) and emodin-type anthroquinones, stilbenes (eg, resveratrol, piceatannol polydatin), flavonoids (eg, quercetin, catechin, rutin), coumarins, lignans, and other compounds.Chen 2012, Du 2013, Hao 2012, Kirino 2012, Li 2013, Peng 2013, Piotrowska 2012, Shen 2011, Zhang 2012
Emodin and phsycion demonstrate anti-inflammatory effects.Shen 2011 The stilbene content, including resveratrol, resveratroloside, polydatin, and piceatannol, are responsible for observed antioxidant activity.Kirino 2012, Piotrowska 2012
Methods of identification have been published, including high-performance liquid chromatography and thin-layer chromatography, which are based on the content of emodin and polydatin (minimum concentrations of 0.6% and 0.15%, respectively, per the Chinese pharmacopoeia). Chemical composition varies seasonally and with harvest time.Babu 2005, Chen 2013, Hao 2012, Peng 2013
Uses and Pharmacology
Research reveals no clinical data regarding the use of Japanese knotweed for antioxidant effect.
Reductions in inflammation and improvements in wound-healing rates were demonstrated with topical application of P. cuspidatum extract in studies in mice.Bralley 2008, Peng 2013, Wu 2012 With oral extract reductions in tumor necrosis factor alpha (TNF-alpha), interleukin (IL-6) and C-reactive protein were found in animals with experimentally induced arthritis.Han 2012 An analgesic effect was also demonstrated in rodents.Han 2012
Limited clinical studies have been conducted. A study among healthy volunteers found a decreased expression of modulators of inflammation in mononuclear cells following 6 weeks of P. cuspidatum extract daily containing resveratrol 40 mg.Ghanim 2010 A small study (N = 20) found decreased plasma TNF-alpha and IL-6 versus placebo.Zahedi 2013
In vitro studies have shown broad antibacterial and antifungal activity of P. cuspidatum extracts.Peng 2013, Piotrowska 2012, Song 2006 Activity against Streptococcus mutans has been investigated in oral health.Ban 2010, Pandit 2012 An ethanol extract showed inhibitory activity against HIV-1 in vitro.Lin 2010, Peng 2013
There are no clinical data regarding the use of P. cuspidatum as an antimicrobial agent.
Studies in rats and mice have shown antioxidant properties of P. cuspidatum that are generally attributed to the chemical constituents of resveratrol, polydatin, piceatannol, and anthraquinones and stilbenes.Kim 2010, Peng 2013, Piotrowska 2012, Zhang 2012 Carbon tetrachloride–induced liver injury and induced acute cerebral ischemia were reduced by oral extracts of P. cuspidatum.Kim 2010, Zhang 2012 In models of vascular dementia and Parkinson disease in rats, P. cuspidatum extract and polydatin administered orally resulted in improved cognitive and behavioral measures and increased antioxidant capacity in the relevant tissues.Li 2012, Wang 2011
There are no clinical data regarding the use of P. cuspidatum for antioxidant effect.
In vitro studies using oral, lung, and prostate cancer cells, and in hepatocarcinoma, glioma, and leukemia have been conducted. Ethanol, methanol and aqueous P. cuspidatum extracts show pro-apoptotic activity and inhibition of angiogenesis, as well as direct cytotoxicity.Hu 2012, Jeong 2010, Lin 2010, Shin 2011 Mice with Ehrlich carcinoma had an increased lifespan when given P. cuspidatum extract.Peng 2013
Research reveals no clinical data for the use of P. cuspidatum regarding cancer.
Studies conducted in the 1980s and 1990s in rodent models of hyperlipidemia showed decreased total cholesterol, as well as decreased triglycerides and low-density lipoprotein.Peng 2013 Oral polydatin from P. cuspidatum showed similar results in rabbits and hamsters.Du 2009, Xing 2009
There are no clinical data regarding the use of P. cuspidatum in hyperlipidemia.
Clinical evidence on which to base dosing guidelines is lacking. One study used an oral extract of P. cuspidatum 200 mg over 6 weeks. The preparation was standardized to contain resveratrol 40 mg.Zahedi 2013
Topical application of P. cuspidatum extract has been studied in mice for anti-inflammatory effects.Bralley 2008, Wu 2012
Pregnancy / Lactation
Do not use in pregnancy. Huzhang is listed as an abortifacient in traditional Chinese medicine texts.Peng 2013
Avoid use during lactation; information regarding use during lactation is lacking.
The area under the curve of carbamazepine and its active metabolite were increased in rats fed P. cuspidatum, suggesting an increased risk of carbamazepine toxicity.Chi 2012
Clinical evidence on which to base guidance is limited. A study conducted in basketball players over 6 weeks did not report adverse events.Zahedi 2013
Information is limited.Du 2013, Peng 2013 The oral median lethal dose (LD50) of anthraquinones in mice is approximately 9 g/kg body weight. The LD50 of emodin and polydatin is 250 and 1,000 mg/kg, respectively. Parenteral polydatin caused peritonitis in a subacute toxicity test in animals. No hemolysis, agglutination reaction, or systemic anaphylaxis/skin allergy was found in tests conducted in rabbits.Peng 2013
- Fallopia japonica (Houtt.) Ronse Decr.
- Pleuropterus cuspidatus (Siebold & Zucc.) Moldenke
- Pleuropterus zuccarinii (Small) Small
- Polygonum cuspidatum Siebold & Zucc. var. compactum (Hook. f.) L.H. Bailey
- Reynoutria japonica Houtt
Babu SK, Kumar KV, Subbaraju GV. Estimation of trans-resveratrol in herbal extracts and dosage forms by high-performance thin-layer chromatography. Chem Pharm Bull (Tokyo). 2005;53(6):691-693.15930785Ban SH, Kwon YR, Pandit S, Lee YS, Yi HK, Jeon JG. Effects of a bio-assay guided fraction from Polygonum cuspidatum root on the viability, acid production and glucosyltranferase of mutans streptococci. Fitoterapia. 2010;81(1):30-34.19616082Bralley EE, Greenspan P, Hargrove JL, Wicker L, Hartle DK. Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation. J Inflamm (Lond). 2008;5:1.18261214Chen BY, Kuo CH, Liu YC, Ye LY, Chen JH, Shieh CJ. Ultrasonic-assisted extraction of the botanical dietary supplement resveratrol and other constituents of Polygonum cuspidatum. J Nat Prod. 2012;75(10):1810-1813.23075087Chen H, Tuck T, Ji X, et al. Quality assessment of Japanese knotweed (Fallopia japonica) grown on Prince Edward Island as a source of resveratrol. J Agric Food Chem. 2013;61(26):6383-6392.23742076Chi YC, Lin SP, Hou YC. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. Toxicol Appl Pharmacol. 2012;263(3):315-322.22813711Du J, Sun LN, Xing WW, et al. Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters. Phytomedicine. 2009;16(6-7):652-658.19106037Du QH, Peng C, Zhang H. Polydatin: A review of pharmacology and pharmacokinetics. Pharm Biol. 2013;51(11):1347-1354.23862567Ghanim H, Sia CL, Abuaysheh S, et al. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab. 2010;95(9):E1-8.20534755Han JH, Koh W, Lee HJ, et al. Analgesic and anti-inflammatory effects of ethyl acetate fraction of Polygonum cuspidatum in experimental animals. Immunopharmacol Immunotoxicol. 2012;34(2):191-195.21711083Hao D, Ma P, Mu J, et al. De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum. Sci China Life Sci. 2012;55(5):452-466.22645089Hu B, An HM, Shen KP, Song HY, Deng S. Polygonum cuspidatum extract induces anoikis in hepatocarcinoma cells associated with generation of reactive oxygen species and downregulation of focal adhesion kinase. Evid Based Complement Alternat Med. 2012;2012:607675.23008742Jeong ET, Jin MH, Kim MS, Chang YH, Park SG. Inhibition of melanogenesis by piceid isolated from Polygonum cuspidatum. Arch Pharm Res. 2010;33(9):1331-1338.20945131Kim J, Kim MY, Leem KH, et al. Key compound groups for the neuroprotective effect of roots of Polygonum cuspidatum on transient middle cerebral artery occlusion in Sprague-Dawley rats. Nat Prod Res. 2010;24(13):1214-1226.20645208Kirino A, Takasuka Y, Nishi A, et al. Analysis and functionality of major polyphenolic components of Polygonum cuspidatum (itadori). J Nutr Sci Vitaminol (Tokyo). 2012;58(4):278-286.23132312Li RP, Wang ZZ, Sun MX, et al. Polydatin protects learning and memory impairments in a rat model of vascular dementia. Phytomedicine. 2012;19(8-9):677-681.22483554Li F, Zhan Z, Liu F, et al. Polyflavanostilbene A, a new flavanol-fused stilbene glycoside from Polygonum cuspidatum. Org Lett. 2013;15(3):674-677.23320550Lin HW, Sun MX, Wang YH, et al. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta Med. 2010;76(9):889-892.20112182Lin YW, Yang FJ, Chen CL, Lee WT, Chen RS. Free radical scavenging activity and antiproliferative potential of Polygonum cuspidatum root extracts. J Nat Med. 2010;64(2):146-152.20082145Pandit S, Kim HJ, Park SH, Jeon JG. Enhancement of fluoride activity against Streptococcus mutans biofilms by a substance separated from Polygonum cuspidatum. Biofouling. 2012;28(3):279-287.22435782Peng W, Qin R, Li X, Zhou H. Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb.et Zucc.: a review. J Ethnopharmacol. 2013;148(3):729-745.23707210Piotrowska H, Kucinska M, Murias M. Biological activity of piceatannol: leaving the shadow of resveratrol. Mutat Res. 2012;750(1):60-82.22108298
Polygonum cuspidatum Siebold & Zucc. 2013. The PLANTS Database (http://plants.usda.gov, 10 October 2013). National Plant Data Team, Greensboro, NC 27401-4901.Shen MY, Liu YJ, Don MJ, et al. Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica. PLoS One. 2011;6(11):e27480.22087325Shin JA, Shim JH, Jeon JG, et al. Apoptotic effect of Polygonum cuspidatum in oral cancer cells through the regulation of specificity protein 1. Oral Dis. 2011;17(2):162-170.20659264Song JH, Kim SK, Chang KW, Han SK, Yi HK, Jeon JG. In vitro inhibitory effects of Polygonum cuspidatum on bacterial viability and virulence factors of Streptococcus mutans and Streptococcus sobrinus. Arch Oral Biol. 2006;51(12):1131-1140.16914113Wang Y, Xu H, Fu Q, Ma R, Xiang J. Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in Parkinsonian rats. J Neurol Sci. 2011;304:29-34.Wu XB, Luo XQ, Gu SY, Xu JH. The effects of Polygonum cuspidatum extract on wound healing in rats. J Ethnopharmacol. 2012;141(3):934-937.22469768Xing WW, Wu JZ, Jia M, Du J, Zhang H, Qin LP. Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits. Biomed Pharmacother. 2009;63(7):457-462.18657948Zahedi HS, Jazayeri S, Ghiasvand R, Djalali M, Eshraghian MR. Effects of polygonum cuspidatum containing resveratrol on inflammation in male professional basketball players. Int J Prev Med. 2013;4(suppl 1):S1-4.23717757Zhang H, Yu CH, Jiang YP, et al. Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. PLoS One. 2012;7(9):e46574.23029551Zhang H, Zhang QW, Wang L, Zhang XQ, Ye WC, Wang YT. Two new anthraquinone malonylglucosides from Polygonum cuspidatum. Nat Prod Res. 2012;26(14):1323-1327.21995450
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