Thuốc Ixabepilone

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Thuốc Ixabepilone
Thuốc Ixabepilone

Holevn Health share articles about :Thuốc Ixabepilone  , side effects – dosage , Thuốc Ixabepilone what disease treatment.Other noted issues. Please refer to the details below.

Generic Name: ixabepilone (IX ab EP i lone)
Brand Name:Ixempra

Medically reviewed by Holevn.org on Jul 26, 2019 – Written by Cerner Multum

What is ixabepilone?

Ixabepilone is used to treat advanced breast cancer.

Ixabepilone is usually given after other cancer medications have been tried without successful treatment.

Ixabepilone may also be used for purposes not listed in this medication guide.

Important Information

Do not use ixabepilone if you are pregnant. It could harm the unborn baby.

You should not receive this medication if you are allergic to ixabepilone, or to a medication ingredient called Cremophor (synthetic castor oil). You may not be able to receive ixabepilone if you have severe liver disease, or severely low platelets or white blood cell counts.

Before you receive ixabepilone, tell your doctor if you have liver disease, heart disease, nerve problems, diabetes, bone marrow suppression, or a weak immune system.

Ixabepilone can lower blood cells that help your body fight infections. Avoid being near people who are sick or have infections. Your blood may need to be tested often. Visit your doctor regularly.

Tell your doctor at once if you develop signs of infection, such as fever, chills, body aches, flu symptoms, pale skin, easy bruising or bleeding, or sores in your mouth and throat.

Avoid drinking alcohol during your treatment with ixabepilone.

Before taking this medicine

You should not receive this medication if you are allergic to ixabepilone, or to a medication ingredient called Cremophor (synthetic castor oil). You may not be able to receive ixabepilone if you have severe liver disease, or severely low platelets or white blood cell counts.

To make sure you can safely receive ixabepilone, tell your doctor if you have any of these other conditions:

  • liver disease;

  • heart disease;

  • nerve problems (especially in your hands or feet);

  • diabetes; or

  • bone marrow suppression or weak immune system.

Do not use ixabepilone if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether ixabepilone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while receiving ixabepilone.

How is ixabepilone given?

Ixabepilone is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Ixabepilone must be given slowly, and the IV infusion can take up to 3 hours to complete.

Ixabepilone is usually given every 3 weeks.

About 1 hour before you receive ixabepilone, you may be given other medications to help prevent certain side effects.

Ixabepilone can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your ixabepilone injection.

What happens if I overdose?

Seek emergency medical attention or call 115.

What should I avoid while receiving ixabepilone?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

ixabepilone can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient’s body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Avoid drinking alcohol during your treatment with ixabepilone.

Ixabepilone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; warmth or tingly feeling; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • numbness, tingling, burning pain, discomfort, or loss of feeling anywhere in your body;

  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  • sudden numbness or weakness, especially on one side of the body;

  • sudden severe headache, confusion, problems with vision, speech, or balance;

  • pain or burning when you urinate;

  • chest pain or heavy feeling; or

  • redness, swelling, and pain on the palms of your hands or the soles of your feet.

Less serious side effects include:

  • tired feeling;

  • joint or muscle pain;

  • hair loss;

  • nausea, vomiting, stomach pain, loss of appetite;

  • diarrhea or constipation; or

  • problems with your fingernails or toenails.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ixabepilone dosing information

Usual Adult Dose for Breast Cancer:

140 mg/m2 IV over 3 hours every 3 weeks (the dosage for patients with a BSA exceeding 2.2 m2 should be calculated based on a 2.2 m2 body surface area)

Comments:
-Premedicate all patients approximately 1 hour prior to administration of this drug to minimize the chance of a hypersensitivity reaction with an H1 antagonist (e.g., diphenhydramine 50 mg orally or equivalent) and an H2 antagonist (e.g., ranitidine 150 to 300 mg orally or equivalent)
-If a patient experiences a hypersensitivity reaction in one cycle, premedicate in subsequent cycles with a corticosteroid (e.g., dexamethasone 20 mg IV 30 minutes prior to infusing this drug or orally 60 minutes prior to infusion) in addition to the H1 and H2 antagonists. Extension of the infusion time should also be considered.

Uses:
-In combination with capecitabine for the treatment of patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated. Anthracycline resistance is defined as progression while on therapy or within 6 months in the adjuvant setting or 3 months in the metastatic setting). Taxane resistance is defined as progression while on therapy or within 12 months in the adjuvant setting or 4 months in the metastatic setting.
-As monotherapy for the treatment of metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes, and capecitabine.

What other drugs will affect ixabepilone?

Many drugs can interact with ixabepilone. Below is just a partial list. Tell your doctor if you are using:

  • bosentan;

  • conivaptan;

  • dexamethasone;

  • imatinib;

  • isoniazid (for treating tuberculosis);

  • nefazodone;

  • St. John’s wort;

  • an antibiotic such as clarithromycin, erythromycin, rifabutin, rifampin, rifapentine, or telithromycin;

  • antifungal medication such as itraconazole, ketoconazole, miconazole, posaconazole, or voriconazole;

  • a barbiturate such as butabarbital, secobarbital, pentobarbital, or phenobarbital;

  • heart or blood pressure medication such as nicardipine or quinidine;

  • the hepatitis C medications boceprevir or telaprevir;

  • HIV/AIDS medication such as atazanavir, delavirdine, efavirenz, etravirine, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, or saquinavir;

  • medicines to treat narcolepsy, such as armodafinil or modafinil; or

  • seizure medication such as carbamazepine, felbamate, oxcarbazepine, phenytoin, or primidone.

This list is not complete and other drugs may interact with ixabepilone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

The content of Holevn is solely for the purpose of providing information about Thuốc Ixabepilone  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/mtm/ixabepilone.html

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