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Medically reviewed by Holevn.org. Last updated on Oct 22, 2019.
Commonly used brand name(s)
In the U.S.
- Cresemba
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antifungal
Chemical Class: Isavuconazonium
Uses for isavuconazonium
Isavuconazonium injection is used to treat serious fungal or yeast infections, such as invasive aspergillosis and invasive mucormycosis. Isavuconazonium works by killing the fungus or yeast and preventing its growth.
Isavuconazonium is to be given only by or under the direct supervision of your doctor.
Before using isavuconazonium
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For isavuconazonium, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to isavuconazonium or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of isavuconazonium injection in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of isavuconazonium injection in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving isavuconazonium, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using isavuconazonium with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Atazanavir
- Boceprevir
- Carbamazepine
- Clarithromycin
- Cobicistat
- Conivaptan
- Delavirdine
- Enzalutamide
- Fosphenytoin
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lumacaftor
- Mephobarbital
- Mitotane
- Nefazodone
- Nelfinavir
- Phenytoin
- Posaconazole
- Rifampin
- Ritonavir
- Saquinavir
- St John’s Wort
- Telaprevir
- Telithromycin
- Tipranavir
- Voriconazole
Using isavuconazonium with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Atorvastatin
- Cyclosporine
- Digoxin
- Lopinavir
- Midazolam
- Mycophenolate Mofetil
- Mycophenolic Acid
- Quinidine
- Sirolimus
- Tacrolimus
Using isavuconazonium with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Bupropion
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using isavuconazonium with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.
- Grapefruit Juice
Other medical problems
The presence of other medical problems may affect the use of isavuconazonium. Make sure you tell your doctor if you have any other medical problems, especially:
- Heart rhythm problem (eg, familial short QT syndrome)—Should not be used in patients with this condition.
- Liver disease—Use with caution. May make this condition worse.
Proper use of isavuconazonium
A nurse or other trained health professional will give you isavuconazonium in a hospital. Isavuconazonium is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for at least 1 hour.
Isavuconazonium comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.
Precautions while using isavuconazonium
It is important that your doctor check your progress after treatment. This is to make sure that the infection is cleared up completely, and to allow your doctor to check for any unwanted effects. Blood tests may be needed to check for unwanted effects.
Do not use isavuconazonium together with carbamazepine (Tegretol®), ketoconazole (Nizoral®), phenobarbital (Luminal®), rifampin (Rifadin®, Rimactane®), ritonavir (Norvir®), or St. John’s wort. Using these medicines together may cause unwanted effects.
Using isavuconazonium while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 28 days after the last dose of isavuconazonium. If you think you have become pregnant while using the medicine, tell your doctor right away.
Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Isavuconazonium may cause a serious allergic reaction called infusion related reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you start to have chills, dizziness, trouble breathing, chest tightness, numbness or tingling, change in sense of touch, or lightheadedness or faintness while you are receiving isavuconazonium.
Isavuconazonium may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using isavuconazonium.
Serious skin reactions can occur with isavuconazonium. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using isavuconazonium.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Isavuconazonium side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody urine
- blurred vision
- chest pain
- confusion
- convulsions
- decreased frequency or amount of urine
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast or irregular heartbeat
- loss of appetite
- lower back or side pain
- muscle pain or cramps
- muscle spasms (tetany) or twitching
- numbness or tingling in the hands, feet, or lips
- seizures
- severe nausea or vomiting
- sweating
- tightness in the chest
- tingling of the hands or feet
- trembling
- trouble breathing
- unusual tiredness or weakness
Less common or rare
- Cough or hoarseness
- dark urine
- fever with or without chills
- hives, itching, or rash
- irritation
- joint pain, stiffness, or swelling
- light-colored stools
- red, swollen skin
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach pain
- unusual bleeding or bruising
- upper right abdominal or stomach pain
- yellow eyes and skin
Incidence not known
- Blistering, peeling, or loosening of the skin
- chills
- diarrhea
- red skin lesions, often with a purple center
- red, irritated eyes
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- anxiety
- back pain
- headache
- heartburn or indigestion
- seeing, hearing, or feeling things that are not there
- trouble sleeping
- unusual excitement, nervousness, or restlessness
Less common or rare
- Continuing ringing or buzzing or other unexplained noise in the ears
- decreased vision
- eye pain
- feeling of constant movement of self or surroundings
- hair loss or thinning of the hair
- hearing loss
- sensation of spinning
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
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Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Isavuconazonium (Intravenous) and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/isavuconazonium-intravenous.html
