The content of Holevn is solely for the purpose of providing information about Thuốc Golodirsen and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/golodirsen.html
Medically reviewed by Holevn.org on Feb 18, 2020 – Written by Cerner Multum
What is golodirsen?
Golodirsen is used to treat Duchenne muscular dystrophy in adults and children who have a certain gene mutation. Your doctor will test you for this gene mutation.
Golodirsen was approved by the US Food and Drug Administration (FDA) on an “accelerated” basis. In clinical studies, some people responded to golodirsen, but further studies are needed.
Golodirsen may also be used for purposes not listed in this medication guide.
Important Information
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
Tell your doctor if you have ever had kidney problems.
Tell your doctor if you are pregnant or breastfeeding.
How is golodirsen given?
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using golodirsen.
Golodirsen is given as an infusion into a vein, usually once per week. A healthcare provider will give you this injection.
golodirsen must be given slowly, and the infusion can take up to 60 minutes to complete.
Your kidney function may need to be checked while you are using this medicine.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your golodirsen injection.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while receiving golodirsen?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity.
Golodirsen side effects
Get emergency medical help if you have signs of an allergic reaction: hives, itching, rash, blistering or peeling; fever; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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pink, brown, or red urine;
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foamy urine; or
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swelling in your face, hands, feet, or stomach.
Common side effects may include:
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headache;
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fever;
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stomach pain;
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falls;
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cough; or
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runny or stuffy nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Golodirsen dosing information
Usual Adult Dose for Muscular Dystrophy:
30 mg/kg via IV infusion weekly
Comments:
-Continued approval for this indication is contingent upon verification of clinical benefit in confirmatory trials.
Use: For the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene that is amenable to exon 53 skipping.
Usual Pediatric Dose for Muscular Dystrophy:
30 mg/kg via IV infusion weekly
Comments:
-Continued approval for this indication is contingent upon verification of clinical benefit in confirmatory trials.
Use: For the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene that is amenable to exon 53 skipping.
What other drugs will affect golodirsen?
Other drugs may affect golodirsen, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.02.
Related questions
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Golodirsen and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/golodirsen.html
