Thuốc Fulvestrant (Intramuscular)

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Thuốc Fulvestrant (Intramuscular)
Thuốc Fulvestrant (Intramuscular)

Holevn Health share articles about :Thuốc Fulvestrant (Intramuscular)  , side effects – dosage , Thuốc Fulvestrant (Intramuscular) what disease treatment.Other noted issues. Please refer to the details below.

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Medically reviewed by Holevn.org. Last updated on Jan 24, 2020.

Commonly used brand name(s)

In the U.S.

  • Faslodex

Available Dosage Forms:

  • Solution

Therapeutic Class: Antiestrogen

Uses for fulvestrant

Fulvestrant injection is used to treat hormone-receptor (HR) positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in postmenopausal women who have not been previously treated with other medicines. It is also used to treat HR positive breast cancer that has progressed or worsened after hormonal therapy.

Fulvestrant injection is also used together with ribociclib to treat HR-positive, HER2-negative advanced or metastatic breast cancer in postmenopausal women who have not been previously treated with other medicines or whose cancer has progressed or worsened after hormonal therapy.

Fulvestrant injection is also used in combination with palbociclib or abemaciclib to treat HR positive, HER2-negative advanced or metastatic (cancer that has spread) breast cancer in women who have received hormonal therapy.

Many of the breast cancer tumors will grow when estrogen is available in the body. Fulvestrant blocks the effects of estrogen in the body. As a result, the amount of estrogen that the tumor is exposed to, is reduced, which will limit the growth of the tumor.

Fulvestrant is to be given only by or under the direct supervision of your doctor.

Before using fulvestrant

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For fulvestrant, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to fulvestrant or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of fulvestrant injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fulvestrant injection in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of fulvestrant. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems or
  • Thrombocytopenia (low platelets in the blood)—Use with caution. May make these conditions worse.
  • Liver disease, moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Liver disease, severe—Use has not been studied in patients with this condition.

Proper use of fulvestrant

Medicines used to treat cancer are very strong and can have many side effects. Before receiving fulvestrant, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

A nurse or other trained health professional will give you fulvestrant in a medical facility. It is given as a shot into the buttocks slowly on days 1, 15, 29, and once every month thereafter.

Fulvestrant comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Your doctor may also give you other medicines (eg, luteinizing hormone-releasing hormone agonist) while being treated with fulvestrant and palbociclib, abemaciclib, or ribociclib, before your menopause.

Cancer medicines can cause nausea or vomiting, even after receiving medicines to prevent it. If you have nausea and vomiting after receiving fulvestrant, talk to your doctor or nurse about ways to control these effects.

Missed dose

Fulvestrant needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Precautions while using fulvestrant

It is very important that your doctor check your progress at regular visits to make sure that fulvestrant is working properly. Blood tests may be needed to check for unwanted effects.

Receiving fulvestrant while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test 7 days before you start receiving fulvestrant to make sure you are not pregnant. Use a highly effective form of birth control to keep from getting pregnant during treatment and for 1 year after your last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

Talk with your doctor before receiving fulvestrant if you plan to have children. Some men and women who receive fulvestrant have become infertile (unable to have children).

Fulvestrant may increase your risk of bleeding. This is more likely to occur if you have bleeding problems or if you are taking a blood thinner (eg, warfarin). Tell your doctor right away if you have unusual bleeding or bruising after receiving fulvestrant.

Fulvestrant may cause you to have bleeding from the vagina, especially when you first start receiving it. If the bleeding continues or is bothersome, check with your doctor right away.

Tell your doctor if you have numbness, tingling, or weakness in your legs after receiving fulvestrant.

Before you have any medical tests, tell the medical doctor in charge that you are using fulvestrant. The results of some tests (eg, serum estradiol) may be affected by fulvestrant.

Fulvestrant side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • chest pain or tightness
  • chills
  • cloudy urine
  • cough
  • difficulty breathing
  • fainting
  • fever
  • hoarseness
  • irregular heartbeat, recurrent
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • tender, swollen glands in the neck
  • tingling of the hands or feet
  • trouble with swallowing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss

Less common

  • Anxiety
  • confusion
  • dizziness or lightheadedness
  • fast heartbeat
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • pain in the chest, groin, or legs, especially the calves
  • pain, redness, or swelling in the arm or leg
  • seizures
  • severe, sudden headache
  • slurred speech
  • stomach cramps
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • tremor
  • vision changes

Incidence not known

  • Dark urine
  • flushing or redness of the skin
  • general feeling of tiredness or weakness
  • headache
  • hives or welts, itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • light-colored stools
  • nausea
  • stomach pain, continuing
  • upper right abdominal pain
  • vaginal bleeding
  • vomiting
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • bladder pain
  • body aches or pain
  • bone pain
  • change in or loss of taste
  • constipation
  • decreased appetite
  • depression
  • diarrhea
  • difficulty having a bowel movement
  • difficulty with moving
  • dry skin
  • dryness or soreness of the throat
  • feeling of warmth or heat
  • feeling sad or empty
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • hair loss or thinning of hair
  • irritability
  • joint pain
  • lack or loss of appetite
  • lack or loss of strength
  • loss of interest or pleasure
  • muscle aches and pains
  • muscle stiffness
  • pain at the injection site
  • pain in the arms or legs
  • pelvic pain
  • shivering
  • stomach pain
  • sudden sweating
  • trouble concentrating
  • voice changes
  • weight loss

Less common

  • Dry eye
  • dry mouth
  • increased tearing
  • nervousness
  • swelling or redness in the joints

Incidence not known

  • Feeling of constant movement of self or surroundings
  • sensation of spinning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Fulvestrant (Intramuscular)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/fulvestrant-intramuscular.html

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