Thuốc Dichroa Root

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Thuốc Dichroa Root
Thuốc Dichroa Root

Hovevn Health chia sẻ bài viết về: Rễ cây Dichroa, tác dụng phụ – liều lượng, Rễ cây Dichroa điều trị bệnh gì. Các vấn đề lưu ý khác. Vui lòng tham khảo các chi tiết dưới đây.

Tên khoa học: Dichroa febrifuga Lộ
Tên thường gọi: Basak, Thanh kiếm vàng lớn, Người da đỏ Anh, Ch’ang shan, Chi-fen ts’ao, Chi-ku ch’ang-shan, Chi-ku feng, Rễ xương gà, Rễ gà cỏ, quinine Trung Quốc, rễ Dichroa, Huang ch’ang-shan, rễ phèn bản địa, Pai ch’ang-shan, T’u ch’ang-shan, Ta chin-tao, con trai Thượng, rễ phèn trắng, rễ phèn vàng

Holevn.org xem xét y tế. Cập nhật lần cuối vào ngày 20 tháng 2 năm 2020.

Tổng quan lâm sàng

Sử dụng

Rễ cây Dichroa đã được sử dụng để điều trị bệnh sốt rét trong nhiều thế kỷ ở Trung Quốc; tuy nhiên, không có thử nghiệm lâm sàng gần đây để hỗ trợ việc sử dụng này.

Liều dùng

Không có nghiên cứu lâm sàng gần đây về rễ dichroa để cung cấp các khuyến nghị về liều dùng.

Chống chỉ định

Chống chỉ định chưa được xác định.

Mang thai / cho con bú

Tránh sử dụng. Thông tin liên quan đến an toàn và hiệu quả trong thai kỳ và cho con bú là thiếu.

Tương tác

Không có tài liệu tốt.

Phản ứng trái ngược

Các tác dụng phụ có thể xảy ra bao gồm buồn nôn, nôn và tiêu chảy. Nhiễm độc gan cũng là một mối quan tâm.

Chất độc

Thông tin hạn chế liên quan đến độc tính của rễ dichroa có sẵn.

Gia đình khoa học

This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Dichroa Root  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/npp/dichroa-root.html

Uses and Pharmacology

Antimalarial activity

With drug resistance from medications such as chloroquine and quinine becoming prevalent, researchers have sought other antimalarial sources. Isolates of D. febrifuga, febrifugine and isofebrifugine, were found to be the active components against malaria; however, chemists could not separate adverse effects (eg, nausea, vomiting, diarrhea) from their beneficial actions.Burger 1999, Zeng 1982, Zhao 1986, Zhu 2012 Febrifugine exerts its antimalarial effects by impairing the haemazoin formation needed for parasite maturation at the trophozoite stage. Various analogues have been synthesized in an effort to minimize adverse effects and enhance bioavailability; some of these compounds have therapeutic indices greater than 10 times that of chloroquine.McLaughlin 2014, Zhu 2009 One study suggested that increased lipophilicity of the analogues was associated with improved antimalarial activity.Doctor’s Manual 1977, Zhu 2012

Animal and in vitro data

Febrifugine and isofebrifugine in certain preparations (eg, acetone extract) demonstrated high antimalarial activity against Plasmodium falciparum and Plasmodiumberghei.Takaya 1999 In a study evaluating the effects of an aqueous extract of D. febrifuga against P. berghei in mice, a reduction in infection rate and an increase in mean survival time were observed.Gopal 1982.Two reports suggest that dichroa extracts alter nitric oxide (NO) concentrations. In mice infected with P. berghei, febrifugine 1 mg/kg/day orally reduced mortality and parasitemia, and increased NO production and plasma concentration, thus contributing to host defense against malaria infection.Murata 1999 In an in vivo study, febrifugine significantly enhanced NO production in mouse peritoneal macrophages, with dose-dependent activations.Murata 1998 However, another study investigating the effects of an aqueous extract of D. febrifuga root demonstrated a decrease in NO production as well as tumor necrosis factor, which plays a role in endotoxin-mediated shock and inflammation. In mouse macrophages, NO synthase and NO serum levels were decreased, suggesting suppression of inflammatory response and possible use as an anti-inflammatory.Kim 2000

Clinical data

Research reveals no clinical data regarding the use of dichroa root for malaria.

Other uses

Changrolin, a Chinese antiarrhythmic drug derived from dichroa, has been studied for its antiarrhythmic effects in small mammal cardiac cells.Chen 2010, Lu 1995 In a study testing synthetic febrifugine analogues, cytotoxic effects against cancer cells lines (KB, MCF7, LU1, and HepG2) were observed.Mai 2014 In vitro testing demonstrated potential tumoricidal properties associated with dichroa root.Mazzio 2009

In one study, febrifugine analogues exerted activity against Leishmania donovani parasites.Pandey 2017 In a study using rat liver, an aqueous extract of D. febrifuga root regulated inflammation-related proteins, suggesting a potential role in the management of inflammation.Choi 2003 Similarly, in another study in lipopolysaccharide-stimulated macrophages, the aqueous. extract exerted anti-inflammatory effects via inhibition of interleukin (IL)-1beta and IL-6 production in a dose-dependent manner. D. febrifuga did not decrease the viability of the cells.Park 2009

Dosing

There are no recent clinical studies of dichroa root to provide dosing recommendations.

Pregnancy / Lactation

Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

None well documented.

Adverse Reactions

Nausea, vomiting, and diarrhea have been reported.Burger 1999 Dichroa root may cause hepatotoxicity.Mojab 2012, Zhu 2012, Zhu 2009

Toxicology

Information regarding toxicity with use of dichroa root is lacking.

References

A Barefoot Doctor’s Manual: Practical Chinese Medicine and Health. Bethesda, MD: US Department of Health, Education & Welfare; 1977;878.Burger A. Understanding Medications. What the Label Doesn’t Tell You. Washington, DC: American Chemical Society Publication; 1999.Burns WR. East meets West: how China almost cured malaria. Endeavour. 2008;32(3):101-106.18691761Chen WH, Yang D, Wang WY, Zhang J, Wang YP. Cellular electrophysiological effects of changrolin in isolated rat cardiac myocytes. Eur J Pharmacol. 2010;647(1-3):139-146.20826150Choi BT, Lee JH, Ko WS, et al. Anti-inflammatory effects of aqueous extract from Dichroa febrifuga root in rat liver. Acta Pharmacol Sin. 2003;24(2):127-132.12546719Gopal H, Mohan V, Purushothaman KK. Effect of Dichroa febrifuga on Plasmodium berghei. Indian J Pathol Microbiol. 1982;25(4):269-272.6762348Hocking, G. A Dictionary of Natural Products. Medford, NJ: Plexus Publishing Inc; 1977;253.Kim YH, Ko WS, Ha MS, et al. The production of nitric oxide and TNF-alpha in peritoneal macrophages is inhibited by Dichroa febrifuga Lour. J Ethnopharmacol. 2000;69(1):35-43.10661882Lu LL, Habuchi Y, Tanaka H, Morikawa J. Electrophysiological effects of changrolin, an anti-arrhythmic agent derived from Dichroa febrifuga, on guinea-pig and rabbit heart cells. Clin Exp Pharmacol Physiol. 1995;22(5):337-341.7554424Mai HD, Thanh GV, Tran VH, et al. Synthesis and biological evaluation of febrifugine analogues. Nat Prod Commun. 2014;9(12):1717-1720.25632466Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res. 2009;23(3):385-398.18844256McLaughlin NP, Evans P, Pines M. The chemistry and biology of febrifugine and halofuginone. Bioorg Med Chem. 2014;22(7):1993-2004.24650700Mojab F. Antimalarial natural products: a review. Avicenna J Phytomed. 2012;2(2):52-62.25050231Murata K, Takano F, Fushiya S, Oshima Y. Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga. J Nat Prod. 1998;61(6):729-733.9644055Murata K, Takano F, Fushiya S, Oshima Y. Potentiation by febrifugine of host defense in mice against Plasmodium berghei NK65. Biochem Pharmacol. 1999;58(10):1593-1601.10535750Pandey RK, Kumbhar BV, Srivastava S, et al. Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors: binding energy analysis assisted by molecular docking, ADMET and molecular dynamics simulation. J Biomol Struct Dyn. 2017;35(1):141-158.27043972Park SY, Park GY, Ko WS, Kim Y. Dichroa febrifuga Lour. inhibits the production of IL-1beta and IL-6 through blocking NF-kappaB, MAPK, and Akt activation in macrophages. J Ethnopharmacol. 2009;125(2):246-251.19607899Takaya Y, Tasaka H, Chiba T, et al. New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite. J Med Chem. 1999;42(16):3163-3166.10447961Taylor J. Introductory Medicinal Chemistry. Chichester, UK: Ellis Horwood Ltd; 1981.10447961Zeng Y. Development of plant derived drugs in China. Pharm Week. 1982;117:1037-1043Zhao CX. Effect of Dichroa febrifuga L. on chloroquinsensible and chloroquinresistant malaria parasites [in German]. J Tongji Med Univ. 1986;6(2):112-115.3528514Zhu S, Chandrashekar G, Meng L, Robinson K, Chatterji D. Febrifugine analogue compounds: synthesis and antimalarial evaluation. Bioorg Med Chem. 2012;20(2):927-932.22182577Zhu S, Zhang Q, Gudise C, Wei L, Smith E, Zeng Y. Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents. Bioorg Med Chem. 2009;17(13):4496-4502.19467876

Disclaimer

This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Dichroa Root  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/npp/dichroa-root.html

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