Hovevn Health chia sẻ bài viết về: Thuốc Cyclophosphamide, tác dụng phụ – liều lượng, thuốc Cyclophosphamide điều trị bệnh gì. Các vấn đề lưu ý khác. Vui lòng tham khảo các chi tiết dưới đây.
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Tên thương hiệu thường được sử dụng
Tại Hoa Kỳ
- Cytoxan
- Cytoxan đông khô
Các dạng bào chế có sẵn:
- Viên con nhộng
- Bột giải pháp
- Máy tính bảng
Lớp trị liệu: Chất chống ung thư
Lớp dược lý: Tác nhân kiềm hóa
Lớp hóa học: Mù tạt nitơ
Sử dụng cho cyclophosphamide
Cyclophosphamide được sử dụng để điều trị ung thư buồng trứng, vú, hệ thống máu và bạch huyết và dây thần kinh (chủ yếu ở trẻ em). Cyclophosphamide cũng được sử dụng cho u nguyên bào võng mạc (một loại ung thư mắt chủ yếu ở trẻ em), đa u tủy (ung thư trong tủy xương) và nấm mycosis (khối u trên da). Nó thuộc nhóm thuốc trị ung thư gọi là tác nhân kiềm hóa.
Cyclophosphamide cũng được sử dụng cho một số loại bệnh thận.
Cyclophosphamide can thiệp vào sự phát triển của các tế bào ung thư, sau đó bị cơ thể phá hủy. Vì sự tăng trưởng của các tế bào cơ thể bình thường cũng có thể bị ảnh hưởng bởi cyclophosphamide, các tác dụng khác cũng sẽ xảy ra. Một số trong số này có thể nghiêm trọng và phải được báo cáo với bác sĩ của bạn. Các tác động khác, như rụng tóc, có thể không nghiêm trọng nhưng có thể gây lo ngại. Một số tác dụng có thể không xảy ra trong nhiều tháng hoặc nhiều năm sau khi thuốc được sử dụng.
- Cough or hoarseness
- fever or chills
- lower back or side pain
- missing menstrual periods
- painful or difficult urination
With high doses and/or long-term treatment
- Blood in the urine
- dizziness, confusion, or agitation
- fast heartbeat
- joint pain
- shortness of breath
- swelling of the feet or lower legs
- unusual tiredness or weakness
Less common
- Black, tarry stools
- pinpoint red spots on the skin
- unusual bleeding or bruising
Rare
- Frequent urination
- redness, swelling, or pain at the injection site
- sores in the mouth and on the lips
- sudden shortness of breath
- unusual thirst
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Darkening of the skin and fingernails
- loss of appetite
- nausea or vomiting
Less common
- Diarrhea
- flushing or redness of the face
- headache
- increased sweating
- skin rash, hives, or itching
- stomach pain
- swollen lips
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Cyclophosphamide and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/cyclophosphamide-oral-intravenous.html
- Adenovirus Vaccine
- Amprenavir
- Atazanavir
- Bacillus of Calmette and Guerin Vaccine, Live
- Boceprevir
- Carbamazepine
- Ceritinib
- Cholera Vaccine, Live
- Cobicistat
- Cyclosporine
- Darunavir
- Dengue Tetravalent Vaccine, Live
- Doxorubicin
- Doxorubicin Hydrochloride Liposome
- Eslicarbazepine Acetate
- Etanercept
- Fosamprenavir
- Fosphenytoin
- Hydrochlorothiazide
- Idarubicin
- Indinavir
- Influenza Virus Vaccine, Live
- Lopinavir
- Nelfinavir
- Nevirapine
- Nilotinib
- Pentostatin
- Phenytoin
- Poliovirus Vaccine, Live
- Ritonavir
- Saquinavir
- Smallpox Vaccine
- St John’s Wort
- Tamoxifen
- Telaprevir
- Tipranavir
- Typhoid Vaccine
- Warfarin
- Yellow Fever Vaccine
Using cyclophosphamide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Ondansetron
- Thiotepa
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of cyclophosphamide. Make sure you tell your doctor if you have any other medical problems, especially:
- Chickenpox (including recent exposure) or
- Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body.
- Gout, history of or
- Kidney stones, history of—Cyclophosphamide may increase levels of uric acid in the body, which can cause gout or kidney stones.
- Infection—May decrease body’s ability to fight infection.
- Kidney disease—The effects of cyclophosphamide may be increased because of slower removal from the body.
- Liver disease—The effect of cyclophosphamide may be decreased.
- Prior removal of adrenal gland(s)—Toxic effects of cyclophosphamide may be increased, dosage adjustment may be necessary.
- Tumor cell accumulation—Increased risk of tumor cells entering the bone marrow, due to bone marrow depression from high doses of cyclophosphamide.
Proper use of cyclophosphamide
Take cyclophosphamide only as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.
Cyclophosphamide is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your doctor to help you plan a way to remember to take your medicines at the right times.
While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine. Also, empty your bladder frequently, including at least once during the night. This will help prevent kidney and bladder problems and keep your kidneys working well. Cyclophosphamide passes from the body in the urine. If too much of it appears in the urine or if the urine stays in the bladder too long, it can cause dangerous irritation. Follow your doctor’s instructions carefully about how much fluid to drink every day. Some patients may have to drink up to 7 to 12 cups (3 quarts) of fluid a day.
Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better. Follow your doctor’s instructions carefully about when to take cyclophosphamide.
Cyclophosphamide often causes nausea, vomiting, and loss of appetite. However, it is very important that you continue to use the medicine even if you begin to feel ill. Do not stop taking cyclophosphamide without first checking with your doctor. Ask your doctor for ways to lessen these effects.
If you vomit shortly after taking a dose of cyclophosphamide, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.
Dosing
The dose of cyclophosphamide will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of cyclophosphamide. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- For the treatment of cancer:
- Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 milligrams (mg) per kilogram (kg) of body weight per day.
- Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 mg per kg of body weight per day.
- For the treatment of cancer:
Missed dose
If you miss a dose of cyclophosphamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions while using cyclophosphamide
It is very important that your doctor check your progress at regular visits to make sure that cyclophosphamide is working properly and to check for unwanted effects.
While you are being treated with cyclophosphamide, and after you stop treatment with it, do not have any immunizations (vaccines) without your doctor’s approval. Cyclophosphamide may lower your body’s resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor.
Before having any kind of surgery, including dental surgery, or emergency treatment, make sure the medical doctor or dentist in charge knows that you are taking cyclophosphamide, especially if you have taken it within the last 10 days.
Cyclophosphamide may cause a temporary loss of hair in some people. After treatment has ended, normal hair growth should return, although the new hair may be a slightly different color or texture.
Cyclophosphamide can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
- If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
- Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin.
- Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
- Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
- Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
- Avoid contact sports or other situations where bruising or injury could occur.
Before you have any medical tests, tell the medical doctor in charge that you are taking cyclophosphamide. The results of some tests may be affected by cyclophosphamide.
Cyclophosphamide side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
- Cough or hoarseness
- fever or chills
- lower back or side pain
- missing menstrual periods
- painful or difficult urination
With high doses and/or long-term treatment
- Blood in the urine
- dizziness, confusion, or agitation
- fast heartbeat
- joint pain
- shortness of breath
- swelling of the feet or lower legs
- unusual tiredness or weakness
Less common
- Black, tarry stools
- pinpoint red spots on the skin
- unusual bleeding or bruising
Rare
- Frequent urination
- redness, swelling, or pain at the injection site
- sores in the mouth and on the lips
- sudden shortness of breath
- unusual thirst
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Darkening of the skin and fingernails
- loss of appetite
- nausea or vomiting
Less common
- Diarrhea
- flushing or redness of the face
- headache
- increased sweating
- skin rash, hives, or itching
- stomach pain
- swollen lips
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Seek emergency medical attention or call 115
Further information
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Cyclophosphamide and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/cons/cyclophosphamide-oral-intravenous.html
