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Generic Name: exenatide (ex EN a tide)
Brand Names: Bydureon
Medically reviewed by Sophia Entringer, PharmD Last updated on Jun 13, 2019.
What is Bydureon?
Bydureon is an extended release injectable diabetes medicine that helps control blood sugar levels. This medication helps your pancreas produce insulin more efficiently. Bydureon is a long-acting form of exenatide.
Bydureon is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.
This medication guide provides information about the Bydureon brand of exenatide. Byetta is another brand of exenatide that is not covered in this medication guide.
You should not use Bydureon if you have severe kidney disease (or you are on dialysis), slowed digestion, diabetic ketoacidosis, a personal or family history of thyroid cancer, or if you have a type of cancer called multiple endocrine neoplasia type 2 (MEN 2).
Stop using Bydureon and call your doctor at once if you have severe pain in your upper stomach spreading to your back, with nausea, vomiting, and a fast heart rate. These could be symptoms of pancreatitis.
Do not use Bydureon to treat type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Bydureon is an extended-release form of exenatide administered as an injection once every seven days. The dose can be administered at any time of day, with or without meals. Follow your doctor’s instructions.
Before taking this medicine
You should not use Bydureon if you are allergic to exenatide, or if you have:
severe kidney disease (or if you are on dialysis);
a severe stomach disorder that causes slow digestion;
diabetic ketoacidosis (call your doctor for treatment with insulin);
a personal or family history of thyroid cancer; or
multiple endocrine neoplasia type 2 (MEN 2, a cancer that can affect the thyroid, parathyroid, and adrenal glands).
To make sure this medicine is safe for you, tell your doctor if you have ever had:
kidney disease, or a kidney transplant;
problems with digestion;
pancreatitis or gall stones;
high triglycerides (a type of fat in blood).
In animal studies, Bydureon caused thyroid tumors. However, very high doses are used in animal studies. It is not known whether these effects would occur in people using doses recommended for human use. Ask your doctor about your personal risk.
It is not known whether Bydureon will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether exenatide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Bydureon is not FDA-approved for use by anyone younger than 18 years old.
How should I use Bydureon?
Use Bydureon exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Bydureon is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.
Read and carefully follow any Instructions for Use provided with your medicine. Do not use Bydureon if you don’t understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.
Prepare your injection only when you are ready to give it. You must give the injection right away after mixing.
Bydureon is usually injected once every 7 days. Bydureon can be used with or without food and given at any time of the day. Follow your doctor’s instructions. You may change your weekly dosing day, but do not inject on your new dosing day if it has been less than 3 days since your last dose.
Bydureon is a powder medicine that must be mixed with a liquid (diluent) before using it. You must give the injection right away after mixing. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Your care provider will show you the best places on your body to inject Bydureon. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Bydureon is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.
Store this medicine in the original container. Refrigerate and use until expiration date. Protect from light.
Do not freeze Bydureon, and throw away the medicine if it has been frozen.
You may also store Bydureon at room temperature for up to 4 weeks.
Bydureon dosing information
Usual Adult Dose for Diabetes Type 2:
-Dose: 2 mg subcutaneously once every seven days; administer at any time of day, with or without meals
-Patients may switch from immediate-release exenatide to extended-release exenatide, although prior treatment with immediate-release exenatide is not necessary.
-For patients who do switch, discontinue immediate-release exenatide on initiation of extended-release; transient elevations in blood glucose may occur and generally improve within the first 2 weeks of initiation.
-For patients concomitantly receiving a sulfonylurea, a lower dose of the sulfonylurea may be required to reduce the risk of hypoglycemia.
Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 3 days away. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call 115.
Overdose can cause severe nausea and vomiting, or signs of low blood sugar (headache, hunger, irritability, dizziness, feeling shaky).
What should I avoid while taking Bydureon?
Do not use Bydureon together with Byetta.
Avoid drinking alcohol. It can lower your blood sugar.
Bydureon side effects
Get emergency medical help if you have signs of an allergic reaction to Bydureon: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
pain, itching, warmth, swelling, skin sores, blisters, skin changes, or a hard lump where the injection was given;
swelling in your neck or throat (enlarged thyroid), hoarse voice, trouble swallowing or breathing;
pancreatitis – severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
low blood sugar – headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or
kidney problems – little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.
Common Bydureon side effects may include:
indigestion, nausea, vomiting, diarrhea, constipation;
itching or a small bump where an injection was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Bydureon?
Bydureon can make it harder for your body to absorb other medicines you take by mouth. Tell your doctor about all medicines you use, and those you start or stop using. Other drugs may interact with exenatide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Bydureon only for the indication prescribed.
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Reference from: https://www.drugs.com/bydureon.html