Holevn Health share articles about :Thuốc Burosumab , side effects – dosage , Thuốc Burosumab what disease treatment.Other noted issues. Please refer to the details below.
Generic Name: burosumab (bur OH sue mab)
Medically reviewed by Holevn.org on May 4, 2018 – Written by Cerner Multum
What is burosumab?
Burosumab is a monoclonal antibody that targets and blocks the activity of a blood protein called FGF23. In a genetic condition called X-linked hypophosphatemia (HYE-poe-fos-fa-TEEM-ee-a), low phosphate levels in blood are caused by abnormally high levels of FGF23 protein, which causes the kidneys to stop reabsorbing phosphate into the bloodstream.
Blocking the FGF23 protein allows the kidneys to restore and maintain normal phosphate levels. Phosphate is important for the strength of your bones and teeth. Low phosphate levels can lead to bone deformities and growth problems.
Burosumab is used to normalize phosphate levels in adults and children who are at least 1 year old and have X-linked hypophosphatemia.
Burosumab may also be used for purposes not listed in this medication guide.
You should not use burosumab if you have severe kidney disease, or if you currently take phosphate or vitamin D by mouth.
Before taking this medicine
You should not use burosumab if you are allergic to it, or if you have:
severe or end-stage kidney disease; or
if you currently take phosphate or vitamin D by mouth.
Tell your doctor if you have ever had:
kidney disease; or
restless leg syndrome.
It is not known whether burosumab will harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using burosumab.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Burosumab is not approved for use by anyone younger than 1 year old.
How is burosumab given?
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using burosumab.
At least 1 week before your first injection, stop using oral phosphate and vitamin D medications.
Burosumab is injected under the skin, once every 2 weeks in children and once every 4 weeks in adults.
A healthcare provider will give you this injection.
Burosumab doses are based on weight in children. Your child’s dose needs may change if the child gains or loses weight.
You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your burosumab injection.
What happens if I overdose?
Seek emergency medical attention or call 115.
What should I avoid while using burosumab?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity.
Burosumab side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Common side effects may include:
pain in your arms, legs, or back;
a restless feeling in your legs;
decreased vitamin D levels;
increased phosphorous levels; or
pain, redness, itching, swelling, bruising, or a hard lump where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect burosumab?
Other drugs may affect burosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.01.
The content of Holevn is solely for the purpose of providing information about Thuốc Burosumab and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/mtm/burosumab.html