Thuốc Brentuximab (Intravenous)

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Thuốc Brentuximab (Intravenous)
Thuốc Brentuximab (Intravenous)

Holevn Health chia sẻ các bài viết về: Thuốc Brentuximab (Tiêm tĩnh mạch), tác dụng phụ – liều dùng, Thuốc Brent Brentuximab (Tiêm tĩnh mạch) điều trị bệnh gì. Các vấn đề lưu ý khác. Vui lòng tham khảo các chi tiết dưới đây.

bren-TUX-i-mab ve-DOE-tin

Đường truyền tĩnh mạch (Powder for Solution)

Nhiễm vi-rút John Castyham (JC) dẫn đến bệnh não chất trắng đa ổ tiến triển (PML) và tử vong có thể xảy ra ở những bệnh nhân dùng brentuximab vedotin.

Holevn.org xem xét y tế. Cập nhật lần cuối vào ngày 2 tháng 8 năm 2019.

Tên thương hiệu thường được sử dụng

Tại Hoa Kỳ

  • Adcetris

Các dạng bào chế có sẵn:

  • Bột giải pháp

Lớp trị liệu: Chất chống ung thư

Lớp dược lý: Thuốc ức chế phân bào

Sử dụng cho brentuximab

Tiêm Brentuximab được sử dụng để điều trị ung thư hạch Hodgkin, u lympho tế bào lớn anaplastic toàn thân (sALCL) và u lympho tế bào lớn anaplastic chính (pcALCL), là ung thư máu. Nó được trao cho những bệnh nhân được ghép tủy xương (tế bào gốc tự thân) hoặc các phương pháp điều trị ung thư khác không hoạt động tốt.

Thuốc tiêm Brentuximab cũng được sử dụng cùng với các loại thuốc trị ung thư khác (ví dụ, doxorubicin, vinblastine, dacarbazine) để điều trị ung thư hạch Hodgkin cổ điển giai đoạn III hoặc IV chưa được điều trị trước đó.

Tiêm Brentuximab cũng được sử dụng cùng với các loại thuốc khác (ví dụ cyclophosphamide, doxorubicin, prednison) để điều trị cho bệnh nhân mắc sALCL chưa được điều trị trước đó hoặc u lympho tế bào T ngoại biên biểu hiện CD30 (PTCL), bao gồm cả u lympho tế bào T (PTCL).

Brentuximab can thiệp vào sự phát triển của các tế bào ung thư, sau đó bị cơ thể phá hủy.

Brentuximab chỉ được cung cấp bởi hoặc dưới sự giám sát trực tiếp của bác sĩ.

Trước khi sử dụng brentuximab

Khi quyết định sử dụng thuốc, rủi ro của việc dùng thuốc phải được cân nhắc với lợi ích mà nó sẽ làm. Đây là một quyết định mà bạn và bác sĩ của bạn sẽ đưa ra. Đối với brentuximab, cần xem xét những điều sau đây:

Dị ứng

Hãy cho bác sĩ của bạn nếu bạn đã từng có bất kỳ phản ứng bất thường hoặc dị ứng với brentuximab hoặc bất kỳ loại thuốc nào khác. Cũng nói với chuyên gia chăm sóc sức khỏe của bạn nếu bạn có bất kỳ loại dị ứng nào khác, chẳng hạn như thực phẩm, thuốc nhuộm, chất bảo quản hoặc động vật. Đối với các sản phẩm không kê đơn, đọc nhãn hoặc thành phần gói cẩn thận.

Nhi khoa

Các nghiên cứu thích hợp đã không được thực hiện về mối quan hệ của tuổi tác với tác động của tiêm brentuximab trong dân số nhi. An toàn và hiệu quả chưa được thành lập.

Lão

Các nghiên cứu phù hợp được thực hiện cho đến nay đã không chứng minh được các vấn đề cụ thể về lão khoa sẽ hạn chế tính hữu ích của việc tiêm brentuximab ở người cao tuổi.

Cho con bú

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Brentuximab side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Using brentuximab with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atazanavir
  • Boceprevir
  • Ceritinib
  • Delavirdine
  • Indinavir
  • Nefazodone
  • Nelfinavir
  • Posaconazole
  • Saquinavir
  • Telithromycin
  • Tipranavir
  • Tofacitinib
  • Voriconazole

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using brentuximab with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use brentuximab, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other medical problems

The presence of other medical problems may affect the use of brentuximab. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diabetes or
  • Hyperglycemia (high sugar in the blood) or
  • Lung or breathing problems or
  • Neutropenia (low white blood cells) or
  • Peripheral neuropathy (nerve problem) or
  • Pneumonitis (inflammation of the lung) or
  • Stomach or bowel problems (eg, bleeding, ulcer) or
  • Thrombocytopenia (low platelets in the blood)—Use with caution. May make these conditions worse.
  • Infection—May decrease your body’s ability to fight an infection.
  • Kidney disease, mild to moderate or
  • Liver disease, mild—Use with caution. The effects may be increased because of slower removal of the medicine from the body
  • Kidney disease, severe or
  • Liver disease, moderate to severe—Should not be used in patients with these conditions.

Proper use of brentuximab

Before receiving brentuximab, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

A nurse or other trained health professional will give you brentuximab in a medical facility. It is given through a needle placed into one of your veins. It must be given slowly, so the needle will have to stay in place for at least 30 minutes every 2 or 3 weeks.

You may also receive other medicines (eg, fever medicine, allergy medicine, steroids, G-CSF) to help prevent possible allergic reactions to the injection.

Precautions while using brentuximab

It is very important that your doctor check your progress at regular visits to make sure brentuximab is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using brentuximab while you are pregnant can harm your unborn baby. Women should use an effective form of birth control to avoid pregnancy during treatment and for at least 6 months after the last dose. Men should use an effective form of birth control to avoid pregnancy in sexual partners during treatment and for at least 6 months after the last dose. If you think a pregnancy has occurred with the medicine, tell your doctor right away.

Talk with your doctor if you plan to have children after receiving brentuximab. Some men may become infertile (unable to have children).

Do not receive brentuximab together with bleomycin (Blenoxane®). Using these medicines together may cause serious side effects (eg, cough or troubled breathing).

Check with your doctor right away if you have burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

Brentuximab may cause an infusion reaction, which can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a fever, chills, trouble breathing, lightheadedness, fainting, or chest pain within a few hours after you receive it.

Brentuximab may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving brentuximab.

Check with your doctor if you have a fever, chills, sore throat, or painful urination. These could be symptoms of an infection.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Brentuximab may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness.

Serious skin reactions can occur with brentuximab. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills.

Brentuximab may cause a rare and serious brain infection called progressive multifocal leukoencephalopathy (PML). Check with your doctor right away if you have vision changes, loss of coordination, clumsiness, memory loss, difficulty speaking or understanding what others say, or muscle weakness in the legs.

Brentuximab may cause new or worsening lung problems. Tell your doctor right away if you have a cough or trouble with breathing after receiving brentuximab.

Stomach or bowel problems may occur with brentuximab. Tell your doctor right away if you have severe stomach pain, heartburn, or indigestion, bloody or black stools, trouble breathing, or if you vomit material that looks like coffee grounds.

Brentuximab may raise your blood sugar levels. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Brentuximab side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Abdominal or stomach pain
  • back pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • body aches or pain
  • bone pain
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • difficult or labored breathing
  • dry mouth
  • ear congestion
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of voice
  • lower back or side pain
  • nausea
  • pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sneezing
  • sore throat
  • stuffy or runny nose
  • sweating
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • troubled breathing with exertion
  • unexplained weight loss
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • weakness in the arms, hands, legs, or feet

Less common

  • Anxiety
  • bladder pain
  • blistering, peeling, or loosening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain
  • cloudy urine
  • confusion
  • diarrhea
  • dizziness or lightheadedness
  • drowsiness
  • fainting
  • fast heartbeat
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • irregular heartbeat
  • itching
  • joint pain, stiffness, or swelling
  • muscle pain
  • rapid weight gain
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • severe pain in the chest
  • sudden onset of severe breathing difficulty
  • thickening of bronchial secretions
  • unusual weight gain or loss

Incidence not known

  • Clay-colored stools
  • dark urine
  • heartburn
  • indigestion
  • severe abdominal pain, cramping, or burning
  • severe constipation
  • severe vomiting
  • vomiting of material that looks like coffee grounds
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased appetite or weight
  • difficulty having a bowel movement
  • difficulty with moving
  • hair loss or thinning of the hair
  • muscle spasm or stiffness
  • night sweats
  • pain in the arms or legs
  • rash
  • trouble sleeping

Less common

  • Dry skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Brentuximab (Intravenous)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/brentuximab-intravenous.html

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