. 2005;98(1):1-14.1567615947. Piscaglia F, Leoni S, Venturi A, Graziella F, Donati G, Bolondi L. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity.
Scand J Gastroenterol
. 2005;40(2):236-239.1576415848. Mejía-Dolores JW, Mendoza-Quispe DE, Moreno-Rumay EL, et al. Neurotoxic effect of aqueous extract of boldo (
Peumus boldus
) in an animal model.
Rev Peru Med Exp Salud Publica
. 2014;31(1):62-68.2471852849. Moreno PR, Vargas VM, Andrade HH, Henriques AT, Henriques JA. Genotoxicity of the boldine aporphine alkaloid in prokaryotic and eukaryotic organisms.
Mutat Res
. 1991;260(2):145-152.204669550. Tavares DC, Takahashi CS. Evaluation of the genotoxic potential of the alkaloid boldine in mammalian cell systems in vitro and in vivo.
Mutat Res
. 1994;321(3):139-145.751306451. Navarro VJ, Barnhart H, Bonkovsky HL, et al. Liver injury from herbals and dietary supplements in the U.S. drug-induced liver injury network.
Hepatology
. 2014;60(4):1399-1408.25043597
Disclaimer
This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.
This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.
Copyright © 2019 Wolters Kluwer Health
Further information
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Boldo and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/npp/boldo.html
Int J Food Microbiol
. 2014;168-169:17-23.2421177516. Bluma R, Amaiden MR, Daghero J, Etcheverry M. Control of Aspergillus section Flavi growth and aflatoxin accumulation by plant essential oils.
J Appl Microbiol
. 2008;105(1):203-214.1828448817. Verdeguer M, García-Rellán D, Boira H, Pérez E, Gandolfo S, Blázquez MA. Herbicidal activity of
Peumus boldus
and
Drimys winterii
essential oils from Chile.
Molecules
. 2011;16(1):403-411.2122105918. Vila R, Valenzuela L, Bello H, Cañigueral S, Montes M, Adzet T. Composition and antimicrobial activity of the essential oil of
Peumus boldus
leaves.
Planta Med
. 1999;65(2):178-179.1019321019. van Krimpen MM, Binnendijk GP, Borgsteede FH, Gaasenbeek CP. Anthelmintic effects of phytogenic feed additives in Ascaris suum inoculated pigs.
Vet Parasitol
. 2010;168(3-4):269-277.1995489120. Speisky H, Cassels BK. Boldo and boldine: an emerging case of natural drug development.
Pharmacol Res
. 1994;29(1):1-12.820244021. Lau YS, Tian XY, Huang Y, Murugan D, Achike FI, Mustafa MR. Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism.
Biochem Pharmacol
. 2013;85(3):367-375.2317865522. Lau YS, Tian XY, Mustafa MR, et al. Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II-mediated BMP4-oxidative stress cascade.
Br J Pharmacol
. 2013;170(6):1190-1198.2399229623. Hernández-Salinas R, Vielma AZ, Arismendi MN, Boric MP, Sáez JC, Velarde V. Boldine prevents renal alterations in diabetic rats.
J Diabetes Res
. 2013;2013:593672.2441672624. Fernández J, Lagos P, Rivera P, Zamorano-Ponce E. Effect of boldo (
Peumus boldus
Molina) infusion on lipoperoxidation induced by cisplatin in mice liver.
Phytother Res
. 2009;23(7):1024-1027.1914557525. Cordero-Pérez P, Torres-González L, Aguirre-Garza M, et al. Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats.
Pharmacognosy Res
. 2013;5(3):150-156.2390088126. Falé PL, Amaral F, Amorim Madeira PJ, et al. Acetylcholinesterase inhibition, antioxidant activity and toxicity of
Peumus boldus
water extracts on HeLa and Caco-2 cell lines.
Food Chem Toxicol
. 2012;50(8):2656-2662.2261735327. Gerhardt D, Bertola G, Dietrich F, et al. Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3beta.
Urol Oncol
. 2014;32(1):36.e1-36.e9.2423946128. Gerhardt D, Horn AP, Gaelzer MM, et al. Boldine: a potential new antiproliferative drug against glioma cell lines.
Invest New Drugs
. 2009;27(6):517-525.1905082729. Russo A, Cardile V, Caggia S, Gunther G, Troncoso N, Garbarino J. Boldo prevents UV light and nitric oxide-mediated plasmid DNA damage and reduces the expression of Hsp70 protein in melanoma cancer cells.
J Pharm Pharmacol
. 2011;63(9):1219-1229.2182749530. Hidalgo M, et al. Boldine as a sunscreen: its photoprotector capacity against UVB radiation.
Cosmet Toiletries
. 1998;113(9):59,60,62-64,66.31. Yu B, Cook C, Santanam N. The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells.
J Med Food
. 2009;12(5):1074-1083.1985707232. Lau YS, Machha A, Achike FI, Murugan D, Mustafa MR. The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats.
Exp Biol Med (Maywood)
. 2012;237(1):93-98.2215604333. Borkowski B, et al. Pharmacodynamic investigations on flavone derivatives from the leaves of
Peumus boldus
.
Herba Pol
. 1965;11(3):198-193.34. Salati R, Lugli R, Tamborino E. Evaluation of the choleretic property of 2 preparations containing extracts of boldo and cascara.
Minerva Dietol Gastroenterol
. 1984;30(3):269-272.650437635. Gotteland M, Jimenez I, Brunser O, et al. Protective effect of boldine in experimental colitis.
Planta Med
. 1997;63(4)311-315.927037436. Gotteland M, Espinoza J, Cassels B, Speisky H. Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers. Rev Med Chil
. 1995;123(8):955-960.865796337. Kang JJ, Cheng YW, Fu WM. Studies on neuromuscular blockade by boldine in the mouse phrenic nerve-diaphragm. Jpn J Pharmacol. 1998;76(2):207-212.954128438. Kang JJ, Cheng YW. Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from skeletal muscle. Planta Med. 1998;64(1):18-21.949176339. Reiniger IW, de Oliveira JF, Caldeira-de-Araújo A, Bernardo-Filho M. Effect of Peumus boldus on the labeling of red blood cells and plasma proteins with technetium-99m. Appl Radiat Isot. 1999;51(2):145-149.1037632640. Braga AC, Oliveira MB, Feliciano GD, et al. The effect of drugs on the labeling of blood elements with technetium-99m. Curr Pharm Des. 2000;6(11):1179-1191.1090338941. Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res. 2000;14(2):99-102.42. Lambert JP, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy. 2001;21(4):509-512.1131052743. Vogel JH, Bolling SF, Costello RB, et al. American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). Integrating complementary medicine into cardiovascular medicine. J Am Coll Cardiol. 2005;46(1):184-221.1599266244. Monzón S, Lezaun A, Sáenz D, et al. Anaphylaxis to boldo infusion, a herbal remedy. Allergy. 2004;59(9):1019-1020.1529192045. Agarwal SC, Crook JR, Pepper CB. Herbal remedies-how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol. 2006;106(2):260-261.1632170146. Izzo AA, Di Carlo G, Borrelli F, Ernst E. Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction. Int J Cardiol. 2005;98(1):1-14.1567615947. Piscaglia F, Leoni S, Venturi A, Graziella F, Donati G, Bolondi L. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol. 2005;40(2):236-239.1576415848. Mejía-Dolores JW, Mendoza-Quispe DE, Moreno-Rumay EL, et al. Neurotoxic effect of aqueous extract of boldo (Peumus boldus) in an animal model. Rev Peru Med Exp Salud Publica. 2014;31(1):62-68.2471852849. Moreno PR, Vargas VM, Andrade HH, Henriques AT, Henriques JA. Genotoxicity of the boldine aporphine alkaloid in prokaryotic and eukaryotic organisms. Mutat Res. 1991;260(2):145-152.204669550. Tavares DC, Takahashi CS. Evaluation of the genotoxic potential of the alkaloid boldine in mammalian cell systems in vitro and in vivo. Mutat Res. 1994;321(3):139-145.751306451. Navarro VJ, Barnhart H, Bonkovsky HL, et al. Liver injury from herbals and dietary supplements in the U.S. drug-induced liver injury network. Hepatology. 2014;60(4):1399-1408.25043597
Disclaimer
This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.
This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.
Copyright © 2019 Wolters Kluwer Health
Further information
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Boldo and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/npp/boldo.html
Int J Food Microbiol. 2014;168-169:17-23.2421177516. Bluma R, Amaiden MR, Daghero J, Etcheverry M. Control of Aspergillus section Flavi growth and aflatoxin accumulation by plant essential oils. J Appl Microbiol. 2008;105(1):203-214.1828448817. Verdeguer M, García-Rellán D, Boira H, Pérez E, Gandolfo S, Blázquez MA. Herbicidal activity of Peumus boldus and Drimys winterii essential oils from Chile. Molecules. 2011;16(1):403-411.2122105918. Vila R, Valenzuela L, Bello H, Cañigueral S, Montes M, Adzet T. Composition and antimicrobial activity of the essential oil of Peumus boldus leaves. Planta Med. 1999;65(2):178-179.1019321019. van Krimpen MM, Binnendijk GP, Borgsteede FH, Gaasenbeek CP. Anthelmintic effects of phytogenic feed additives in Ascaris suum inoculated pigs. Vet Parasitol. 2010;168(3-4):269-277.1995489120. Speisky H, Cassels BK. Boldo and boldine: an emerging case of natural drug development. Pharmacol Res. 1994;29(1):1-12.820244021. Lau YS, Tian XY, Huang Y, Murugan D, Achike FI, Mustafa MR. Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism. Biochem Pharmacol. 2013;85(3):367-375.2317865522. Lau YS, Tian XY, Mustafa MR, et al. Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II-mediated BMP4-oxidative stress cascade. Br J Pharmacol. 2013;170(6):1190-1198.2399229623. Hernández-Salinas R, Vielma AZ, Arismendi MN, Boric MP, Sáez JC, Velarde V. Boldine prevents renal alterations in diabetic rats. J Diabetes Res. 2013;2013:593672.2441672624. Fernández J, Lagos P, Rivera P, Zamorano-Ponce E. Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver. Phytother Res. 2009;23(7):1024-1027.1914557525. Cordero-Pérez P, Torres-González L, Aguirre-Garza M, et al. Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats. Pharmacognosy Res. 2013;5(3):150-156.2390088126. Falé PL, Amaral F, Amorim Madeira PJ, et al. Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines. Food Chem Toxicol. 2012;50(8):2656-2662.2261735327. Gerhardt D, Bertola G, Dietrich F, et al. Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3beta. Urol Oncol. 2014;32(1):36.e1-36.e9.2423946128. Gerhardt D, Horn AP, Gaelzer MM, et al. Boldine: a potential new antiproliferative drug against glioma cell lines. Invest New Drugs. 2009;27(6):517-525.1905082729. Russo A, Cardile V, Caggia S, Gunther G, Troncoso N, Garbarino J. Boldo prevents UV light and nitric oxide-mediated plasmid DNA damage and reduces the expression of Hsp70 protein in melanoma cancer cells. J Pharm Pharmacol. 2011;63(9):1219-1229.2182749530. Hidalgo M, et al. Boldine as a sunscreen: its photoprotector capacity against UVB radiation. Cosmet Toiletries. 1998;113(9):59,60,62-64,66.31. Yu B, Cook C, Santanam N. The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells. J Med Food. 2009;12(5):1074-1083.1985707232. Lau YS, Machha A, Achike FI, Murugan D, Mustafa MR. The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats. Exp Biol Med (Maywood). 2012;237(1):93-98.2215604333. Borkowski B, et al. Pharmacodynamic investigations on flavone derivatives from the leaves of Peumus boldus. Herba Pol. 1965;11(3):198-193.34. Salati R, Lugli R, Tamborino E. Evaluation of the choleretic property of 2 preparations containing extracts of boldo and cascara. Minerva Dietol Gastroenterol. 1984;30(3):269-272.650437635. Gotteland M, Jimenez I, Brunser O, et al. Protective effect of boldine in experimental colitis. Planta Med. 1997;63(4)311-315.927037436. Gotteland M, Espinoza J, Cassels B, Speisky H. Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers. Rev Med Chil. 1995;123(8):955-960.865796337. Kang JJ, Cheng YW, Fu WM. Studies on neuromuscular blockade by boldine in the mouse phrenic nerve-diaphragm. Jpn J Pharmacol. 1998;76(2):207-212.954128438. Kang JJ, Cheng YW. Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from skeletal muscle. Planta Med. 1998;64(1):18-21.949176339. Reiniger IW, de Oliveira JF, Caldeira-de-Araújo A, Bernardo-Filho M. Effect of Peumus boldus on the labeling of red blood cells and plasma proteins with technetium-99m. Appl Radiat Isot. 1999;51(2):145-149.1037632640. Braga AC, Oliveira MB, Feliciano GD, et al. The effect of drugs on the labeling of blood elements with technetium-99m. Curr Pharm Des. 2000;6(11):1179-1191.1090338941. Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res. 2000;14(2):99-102.42. Lambert JP, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy. 2001;21(4):509-512.1131052743. Vogel JH, Bolling SF, Costello RB, et al. American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). Integrating complementary medicine into cardiovascular medicine. J Am Coll Cardiol. 2005;46(1):184-221.1599266244. Monzón S, Lezaun A, Sáenz D, et al. Anaphylaxis to boldo infusion, a herbal remedy. Allergy. 2004;59(9):1019-1020.1529192045. Agarwal SC, Crook JR, Pepper CB. Herbal remedies-how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol. 2006;106(2):260-261.1632170146. Izzo AA, Di Carlo G, Borrelli F, Ernst E. Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction. Int J Cardiol. 2005;98(1):1-14.1567615947. Piscaglia F, Leoni S, Venturi A, Graziella F, Donati G, Bolondi L. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol. 2005;40(2):236-239.1576415848. Mejía-Dolores JW, Mendoza-Quispe DE, Moreno-Rumay EL, et al. Neurotoxic effect of aqueous extract of boldo (Peumus boldus) in an animal model. Rev Peru Med Exp Salud Publica. 2014;31(1):62-68.2471852849. Moreno PR, Vargas VM, Andrade HH, Henriques AT, Henriques JA. Genotoxicity of the boldine aporphine alkaloid in prokaryotic and eukaryotic organisms. Mutat Res. 1991;260(2):145-152.204669550. Tavares DC, Takahashi CS. Evaluation of the genotoxic potential of the alkaloid boldine in mammalian cell systems in vitro and in vivo. Mutat Res. 1994;321(3):139-145.751306451. Navarro VJ, Barnhart H, Bonkovsky HL, et al. Liver injury from herbals and dietary supplements in the U.S. drug-induced liver injury network. Hepatology. 2014;60(4):1399-1408.25043597
Disclaimer
This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.
This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.
Copyright © 2019 Wolters Kluwer Health
Further information
Medical Disclaimer
The content of Holevn is solely for the purpose of providing information about Thuốc Boldo and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.
Reference from: https://www.drugs.com/npp/boldo.html
