Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)

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Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)
Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)

Tetracycline may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking tetracycline:

  • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
  • Wear protective clothing, including a hat. Also, wear sunglasses.
  • Apply a sunblock product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
  • Apply a sunblock lipstick that has an SPF of at least 15 to protect your lips.
  • Do not use a sunlamp or tanning bed or booth.

You may still be more sensitive to sunlight or sunlamps for 2 weeks to several months or more after stopping tetracycline. If you have a severe reaction, check with your doctor.

Bismuth subsalicylate may cause dark tongue and/or black stools. This is only temporary and will go away after you stop taking bismuth subsalicylate, metronidazole, and tetracycline.

Bismuth subsalicylate, metronidazole, and tetracycline lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. Avoid people who are sick. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

If you develop a skin rash, hives, or any allergic reaction to bismuth subsalicylate, metronidazole, and tetracycline, stop taking the medicine and check with your doctor as soon as possible.

Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking tetracycline in this combination of medicines.

Make sure any doctor or dentist who treats you knows that you are using bismuth subsalicylate, metronidazole, and tetracycline. Bismuth subsalicylate, metronidazole, and tetracycline may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Bismuth subsalicylate, metronidazole, and tetracycline side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Abdominal or stomach pain
  • bloody or black, tarry stools
  • diarrhea
  • nausea

Less common

  • Burning, prickling, or tingling sensations
  • dizziness
  • vomiting

Rare

  • Bloody vomit
  • convulsions (seizures)
  • fainting
  • heart attack
  • irritation of the mouth or tongue
  • joint pain and swelling
  • sensitivity of the skin to sunlight
  • skin rash
  • trouble with swallowing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  • Clumsiness or unsteadiness
  • confusion
  • continuing ringing or buzzing in ears
  • fast heartbeat
  • fast or deep breathing
  • fever
  • pain, numbness, or tingling in the arms, legs, hands, or feet
  • unusual tiredness
  • vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Burning or itching around the anus
  • constipation
  • general feeling of discomfort or illness
  • loss of appetite
  • nervousness
  • trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/bismuth-subsalicylate-metronidazole-and-tetracycline.html

Using bismuth subsalicylate, metronidazole, and tetracycline with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use bismuth subsalicylate, metronidazole, and tetracycline, or give you special instructions about the use of food, alcohol, or tobacco.

    • Dairy Food

    Other medical problems

    The presence of other medical problems may affect the use of bismuth subsalicylate, metronidazole, and tetracycline. Make sure you tell your doctor if you have any other medical problems, especially:

    • Allergy to aspirin or other salicylates or
    • Kidney disease, severe—Should not be used in patients with this condition.
    • Blood disorder (e.g., leukopenia, neutropenia), or history of or
    • Brain disease or
    • Central nervous system disease or—Use with caution. May make these conditions worse.
    • Kidney disease or
    • Liver disease—Use with caution. The effects may be increased because of slower removal of metronidazole and tetracycline from the body.

    Proper use of bismuth subsalicylate, metronidazole, and tetracycline

    Take bismuth subsalicylate, metronidazole, and tetracycline exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

    Helidac® comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

    Each day’s therapy is packaged in a blister card that contains 8 chewable tablets of bismuth subsalicylate, 4 tablets of metronidazole, and 4 capsules of tetracycline.

    Pay attention to how to take each medicine. Completely chew and swallow 2 bismuth tablets. Swallow the metronidazole tablets and tetracycline capsules with a full glass of water. This will help prevent irritation of the esophagus (tube between the throat and stomach). Do not chew, crush, or break the metronidazole tablets and tetracycline capsules.

    Your doctor will also prescribe another medicine, a histamine H2 receptor antagonist, which will come with its own directions and must be taken along with this combination of medicines.

    Avoid taking milk, dairy products, antacids containing aluminum, calcium, or magnesium (e.g., Maalox®, Tums®), or supplements containing iron, zinc, or sodium bicarbonate. This may keep tetracycline from working properly.

    To help clear up your infection completely, keep using bismuth subsalicylate, metronidazole, and tetracycline for the full time of treatment, even if you begin to feel better after a few days. If you stop taking bismuth subsalicylate, metronidazole, and tetracycline too soon, your symptoms may return.

    Dosing

    The dose of bismuth subsalicylate, metronidazole, and tetracycline will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of bismuth subsalicylate, metronidazole, and tetracycline. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    • For oral dosage forms (blister card containing chewable tablets, tablets, and capsules):
      • For treatment of duodenal ulcers caused by H. pylori infection:
        • Adults—One dose (525 milligrams [mg] of bismuth subsalicylate, 250 mg of metronidazole, and 500 mg of tetracycline) four times a day, taken with meals and at bedtime, for 14 days.
        • Children—Use and dose must be determined by your doctor.

    Missed dose

    If you miss a dose of bismuth subsalicylate, metronidazole, and tetracycline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    If you miss more than four doses of this combination of medicines, check with your doctor.

    Storage

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

    Keep out of the reach of children.

    Do not keep outdated medicine or medicine no longer needed.

    Ask your healthcare professional how you should dispose of any medicine you do not use.

    Precautions while using bismuth subsalicylate, metronidazole, and tetracycline

    If your condition does not improve or if it becomes worse, check with your doctor.

    Using bismuth subsalicylate, metronidazole, and tetracycline while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. Your birth control pills may not work as well while you are using bismuth subsalicylate, metronidazole, and tetracycline. If you think you have become pregnant while using bismuth subsalicylate, metronidazole, and tetracycline, tell your doctor right away.

    Do not take bismuth subsalicylate, metronidazole, and tetracycline if you are also using disulfiram (Antabuse®) or methoxyflurane (Penthrane®).

    Drinking alcoholic beverages while taking metronidazole may cause stomach pain, nausea, vomiting, headache, or flushing or redness of the face. Other alcohol-containing preparations (e.g., elixirs, cough syrups, tonics) may also cause problems. Do not drink alcoholic beverages or take other products containing propylene glycol while you are taking Helidac® and for at least 3 days after stopping it.

    Metronidazole may cause some people to become dizzy, clumsy, or trouble seeing clearly.

    Children or teenagers who have or who are recovering from chickenpox or influenza should not use this combination of medicines unless directed by the child’s doctor. If nausea or vomiting occurs after taking this combination of medicines, check with the child’s doctor.

    Tetracycline may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking tetracycline:

    • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
    • Wear protective clothing, including a hat. Also, wear sunglasses.
    • Apply a sunblock product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
    • Apply a sunblock lipstick that has an SPF of at least 15 to protect your lips.
    • Do not use a sunlamp or tanning bed or booth.

    You may still be more sensitive to sunlight or sunlamps for 2 weeks to several months or more after stopping tetracycline. If you have a severe reaction, check with your doctor.

    Bismuth subsalicylate may cause dark tongue and/or black stools. This is only temporary and will go away after you stop taking bismuth subsalicylate, metronidazole, and tetracycline.

    Bismuth subsalicylate, metronidazole, and tetracycline lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. Avoid people who are sick. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

    If you develop a skin rash, hives, or any allergic reaction to bismuth subsalicylate, metronidazole, and tetracycline, stop taking the medicine and check with your doctor as soon as possible.

    Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking tetracycline in this combination of medicines.

    Make sure any doctor or dentist who treats you knows that you are using bismuth subsalicylate, metronidazole, and tetracycline. Bismuth subsalicylate, metronidazole, and tetracycline may affect the results of certain medical tests.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

    Bismuth subsalicylate, metronidazole, and tetracycline side effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:

    More common

    • Abdominal or stomach pain
    • bloody or black, tarry stools
    • diarrhea
    • nausea

    Less common

    • Burning, prickling, or tingling sensations
    • dizziness
    • vomiting

    Rare

    • Bloody vomit
    • convulsions (seizures)
    • fainting
    • heart attack
    • irritation of the mouth or tongue
    • joint pain and swelling
    • sensitivity of the skin to sunlight
    • skin rash
    • trouble with swallowing

    Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of overdose

    • Clumsiness or unsteadiness
    • confusion
    • continuing ringing or buzzing in ears
    • fast heartbeat
    • fast or deep breathing
    • fever
    • pain, numbness, or tingling in the arms, legs, hands, or feet
    • unusual tiredness
    • vomiting

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Less common or rare

    • Burning or itching around the anus
    • constipation
    • general feeling of discomfort or illness
    • loss of appetite
    • nervousness
    • trouble sleeping

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Seek emergency medical attention or call 115

    Further information

    The content of Holevn is solely for the purpose of providing information about Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

    Reference from: https://www.drugs.com/cons/bismuth-subsalicylate-metronidazole-and-tetracycline.html

    Using bismuth subsalicylate, metronidazole, and tetracycline with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use bismuth subsalicylate, metronidazole, and tetracycline, or give you special instructions about the use of food, alcohol, or tobacco.

    • Dairy Food

    Other medical problems

    The presence of other medical problems may affect the use of bismuth subsalicylate, metronidazole, and tetracycline. Make sure you tell your doctor if you have any other medical problems, especially:

    • Allergy to aspirin or other salicylates or
    • Kidney disease, severe—Should not be used in patients with this condition.
    • Blood disorder (e.g., leukopenia, neutropenia), or history of or
    • Brain disease or
    • Central nervous system disease or—Use with caution. May make these conditions worse.
    • Kidney disease or
    • Liver disease—Use with caution. The effects may be increased because of slower removal of metronidazole and tetracycline from the body.

    Proper use of bismuth subsalicylate, metronidazole, and tetracycline

    Take bismuth subsalicylate, metronidazole, and tetracycline exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

    Helidac® comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

    Each day’s therapy is packaged in a blister card that contains 8 chewable tablets of bismuth subsalicylate, 4 tablets of metronidazole, and 4 capsules of tetracycline.

    Pay attention to how to take each medicine. Completely chew and swallow 2 bismuth tablets. Swallow the metronidazole tablets and tetracycline capsules with a full glass of water. This will help prevent irritation of the esophagus (tube between the throat and stomach). Do not chew, crush, or break the metronidazole tablets and tetracycline capsules.

    Your doctor will also prescribe another medicine, a histamine H2 receptor antagonist, which will come with its own directions and must be taken along with this combination of medicines.

    Avoid taking milk, dairy products, antacids containing aluminum, calcium, or magnesium (e.g., Maalox®, Tums®), or supplements containing iron, zinc, or sodium bicarbonate. This may keep tetracycline from working properly.

    To help clear up your infection completely, keep using bismuth subsalicylate, metronidazole, and tetracycline for the full time of treatment, even if you begin to feel better after a few days. If you stop taking bismuth subsalicylate, metronidazole, and tetracycline too soon, your symptoms may return.

    Dosing

    The dose of bismuth subsalicylate, metronidazole, and tetracycline will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of bismuth subsalicylate, metronidazole, and tetracycline. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    • For oral dosage forms (blister card containing chewable tablets, tablets, and capsules):
      • For treatment of duodenal ulcers caused by H. pylori infection:
        • Adults—One dose (525 milligrams [mg] of bismuth subsalicylate, 250 mg of metronidazole, and 500 mg of tetracycline) four times a day, taken with meals and at bedtime, for 14 days.
        • Children—Use and dose must be determined by your doctor.

    Missed dose

    If you miss a dose of bismuth subsalicylate, metronidazole, and tetracycline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    If you miss more than four doses of this combination of medicines, check with your doctor.

    Storage

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

    Keep out of the reach of children.

    Do not keep outdated medicine or medicine no longer needed.

    Ask your healthcare professional how you should dispose of any medicine you do not use.

    Precautions while using bismuth subsalicylate, metronidazole, and tetracycline

    If your condition does not improve or if it becomes worse, check with your doctor.

    Using bismuth subsalicylate, metronidazole, and tetracycline while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. Your birth control pills may not work as well while you are using bismuth subsalicylate, metronidazole, and tetracycline. If you think you have become pregnant while using bismuth subsalicylate, metronidazole, and tetracycline, tell your doctor right away.

    Do not take bismuth subsalicylate, metronidazole, and tetracycline if you are also using disulfiram (Antabuse®) or methoxyflurane (Penthrane®).

    Drinking alcoholic beverages while taking metronidazole may cause stomach pain, nausea, vomiting, headache, or flushing or redness of the face. Other alcohol-containing preparations (e.g., elixirs, cough syrups, tonics) may also cause problems. Do not drink alcoholic beverages or take other products containing propylene glycol while you are taking Helidac® and for at least 3 days after stopping it.

    Metronidazole may cause some people to become dizzy, clumsy, or trouble seeing clearly.

    Children or teenagers who have or who are recovering from chickenpox or influenza should not use this combination of medicines unless directed by the child’s doctor. If nausea or vomiting occurs after taking this combination of medicines, check with the child’s doctor.

    Tetracycline may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking tetracycline:

    • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
    • Wear protective clothing, including a hat. Also, wear sunglasses.
    • Apply a sunblock product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
    • Apply a sunblock lipstick that has an SPF of at least 15 to protect your lips.
    • Do not use a sunlamp or tanning bed or booth.

    You may still be more sensitive to sunlight or sunlamps for 2 weeks to several months or more after stopping tetracycline. If you have a severe reaction, check with your doctor.

    Bismuth subsalicylate may cause dark tongue and/or black stools. This is only temporary and will go away after you stop taking bismuth subsalicylate, metronidazole, and tetracycline.

    Bismuth subsalicylate, metronidazole, and tetracycline lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. Avoid people who are sick. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

    If you develop a skin rash, hives, or any allergic reaction to bismuth subsalicylate, metronidazole, and tetracycline, stop taking the medicine and check with your doctor as soon as possible.

    Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking tetracycline in this combination of medicines.

    Make sure any doctor or dentist who treats you knows that you are using bismuth subsalicylate, metronidazole, and tetracycline. Bismuth subsalicylate, metronidazole, and tetracycline may affect the results of certain medical tests.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

    Bismuth subsalicylate, metronidazole, and tetracycline side effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:

    More common

    • Abdominal or stomach pain
    • bloody or black, tarry stools
    • diarrhea
    • nausea

    Less common

    • Burning, prickling, or tingling sensations
    • dizziness
    • vomiting

    Rare

    • Bloody vomit
    • convulsions (seizures)
    • fainting
    • heart attack
    • irritation of the mouth or tongue
    • joint pain and swelling
    • sensitivity of the skin to sunlight
    • skin rash
    • trouble with swallowing

    Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of overdose

    • Clumsiness or unsteadiness
    • confusion
    • continuing ringing or buzzing in ears
    • fast heartbeat
    • fast or deep breathing
    • fever
    • pain, numbness, or tingling in the arms, legs, hands, or feet
    • unusual tiredness
    • vomiting

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Less common or rare

    • Burning or itching around the anus
    • constipation
    • general feeling of discomfort or illness
    • loss of appetite
    • nervousness
    • trouble sleeping

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Seek emergency medical attention or call 115

    Further information

    The content of Holevn is solely for the purpose of providing information about Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

    Reference from: https://www.drugs.com/cons/bismuth-subsalicylate-metronidazole-and-tetracycline.html

    Using bismuth subsalicylate, metronidazole, and tetracycline with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use bismuth subsalicylate, metronidazole, and tetracycline, or give you special instructions about the use of food, alcohol, or tobacco.

    • Dairy Food

    Other medical problems

    The presence of other medical problems may affect the use of bismuth subsalicylate, metronidazole, and tetracycline. Make sure you tell your doctor if you have any other medical problems, especially:

    • Allergy to aspirin or other salicylates or
    • Kidney disease, severe—Should not be used in patients with this condition.
    • Blood disorder (e.g., leukopenia, neutropenia), or history of or
    • Brain disease or
    • Central nervous system disease or—Use with caution. May make these conditions worse.
    • Kidney disease or
    • Liver disease—Use with caution. The effects may be increased because of slower removal of metronidazole and tetracycline from the body.

    Proper use of bismuth subsalicylate, metronidazole, and tetracycline

    Take bismuth subsalicylate, metronidazole, and tetracycline exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

    Helidac® comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

    Each day’s therapy is packaged in a blister card that contains 8 chewable tablets of bismuth subsalicylate, 4 tablets of metronidazole, and 4 capsules of tetracycline.

    Pay attention to how to take each medicine. Completely chew and swallow 2 bismuth tablets. Swallow the metronidazole tablets and tetracycline capsules with a full glass of water. This will help prevent irritation of the esophagus (tube between the throat and stomach). Do not chew, crush, or break the metronidazole tablets and tetracycline capsules.

    Your doctor will also prescribe another medicine, a histamine H2 receptor antagonist, which will come with its own directions and must be taken along with this combination of medicines.

    Avoid taking milk, dairy products, antacids containing aluminum, calcium, or magnesium (e.g., Maalox®, Tums®), or supplements containing iron, zinc, or sodium bicarbonate. This may keep tetracycline from working properly.

    To help clear up your infection completely, keep using bismuth subsalicylate, metronidazole, and tetracycline for the full time of treatment, even if you begin to feel better after a few days. If you stop taking bismuth subsalicylate, metronidazole, and tetracycline too soon, your symptoms may return.

    Dosing

    The dose of bismuth subsalicylate, metronidazole, and tetracycline will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of bismuth subsalicylate, metronidazole, and tetracycline. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    • For oral dosage forms (blister card containing chewable tablets, tablets, and capsules):
      • For treatment of duodenal ulcers caused by H. pylori infection:
        • Adults—One dose (525 milligrams [mg] of bismuth subsalicylate, 250 mg of metronidazole, and 500 mg of tetracycline) four times a day, taken with meals and at bedtime, for 14 days.
        • Children—Use and dose must be determined by your doctor.

    Missed dose

    If you miss a dose of bismuth subsalicylate, metronidazole, and tetracycline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    If you miss more than four doses of this combination of medicines, check with your doctor.

    Storage

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

    Keep out of the reach of children.

    Do not keep outdated medicine or medicine no longer needed.

    Ask your healthcare professional how you should dispose of any medicine you do not use.

    Precautions while using bismuth subsalicylate, metronidazole, and tetracycline

    If your condition does not improve or if it becomes worse, check with your doctor.

    Using bismuth subsalicylate, metronidazole, and tetracycline while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. Your birth control pills may not work as well while you are using bismuth subsalicylate, metronidazole, and tetracycline. If you think you have become pregnant while using bismuth subsalicylate, metronidazole, and tetracycline, tell your doctor right away.

    Do not take bismuth subsalicylate, metronidazole, and tetracycline if you are also using disulfiram (Antabuse®) or methoxyflurane (Penthrane®).

    Drinking alcoholic beverages while taking metronidazole may cause stomach pain, nausea, vomiting, headache, or flushing or redness of the face. Other alcohol-containing preparations (e.g., elixirs, cough syrups, tonics) may also cause problems. Do not drink alcoholic beverages or take other products containing propylene glycol while you are taking Helidac® and for at least 3 days after stopping it.

    Metronidazole may cause some people to become dizzy, clumsy, or trouble seeing clearly.

    Children or teenagers who have or who are recovering from chickenpox or influenza should not use this combination of medicines unless directed by the child’s doctor. If nausea or vomiting occurs after taking this combination of medicines, check with the child’s doctor.

    Tetracycline may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking tetracycline:

    • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
    • Wear protective clothing, including a hat. Also, wear sunglasses.
    • Apply a sunblock product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
    • Apply a sunblock lipstick that has an SPF of at least 15 to protect your lips.
    • Do not use a sunlamp or tanning bed or booth.

    You may still be more sensitive to sunlight or sunlamps for 2 weeks to several months or more after stopping tetracycline. If you have a severe reaction, check with your doctor.

    Bismuth subsalicylate may cause dark tongue and/or black stools. This is only temporary and will go away after you stop taking bismuth subsalicylate, metronidazole, and tetracycline.

    Bismuth subsalicylate, metronidazole, and tetracycline lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. Avoid people who are sick. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

    If you develop a skin rash, hives, or any allergic reaction to bismuth subsalicylate, metronidazole, and tetracycline, stop taking the medicine and check with your doctor as soon as possible.

    Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking tetracycline in this combination of medicines.

    Make sure any doctor or dentist who treats you knows that you are using bismuth subsalicylate, metronidazole, and tetracycline. Bismuth subsalicylate, metronidazole, and tetracycline may affect the results of certain medical tests.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

    Bismuth subsalicylate, metronidazole, and tetracycline side effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:

    More common

    • Abdominal or stomach pain
    • bloody or black, tarry stools
    • diarrhea
    • nausea

    Less common

    • Burning, prickling, or tingling sensations
    • dizziness
    • vomiting

    Rare

    • Bloody vomit
    • convulsions (seizures)
    • fainting
    • heart attack
    • irritation of the mouth or tongue
    • joint pain and swelling
    • sensitivity of the skin to sunlight
    • skin rash
    • trouble with swallowing

    Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of overdose

    • Clumsiness or unsteadiness
    • confusion
    • continuing ringing or buzzing in ears
    • fast heartbeat
    • fast or deep breathing
    • fever
    • pain, numbness, or tingling in the arms, legs, hands, or feet
    • unusual tiredness
    • vomiting

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Less common or rare

    • Burning or itching around the anus
    • constipation
    • general feeling of discomfort or illness
    • loss of appetite
    • nervousness
    • trouble sleeping

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Seek emergency medical attention or call 115

    Further information

    The content of Holevn is solely for the purpose of providing information about Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

    Reference from: https://www.drugs.com/cons/bismuth-subsalicylate-metronidazole-and-tetracycline.html

    Using bismuth subsalicylate, metronidazole, and tetracycline with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use bismuth subsalicylate, metronidazole, and tetracycline, or give you special instructions about the use of food, alcohol, or tobacco.

    • Dairy Food

    Other medical problems

    The presence of other medical problems may affect the use of bismuth subsalicylate, metronidazole, and tetracycline. Make sure you tell your doctor if you have any other medical problems, especially:

    • Allergy to aspirin or other salicylates or
    • Kidney disease, severe—Should not be used in patients with this condition.
    • Blood disorder (e.g., leukopenia, neutropenia), or history of or
    • Brain disease or
    • Central nervous system disease or—Use with caution. May make these conditions worse.
    • Kidney disease or
    • Liver disease—Use with caution. The effects may be increased because of slower removal of metronidazole and tetracycline from the body.

    Proper use of bismuth subsalicylate, metronidazole, and tetracycline

    Take bismuth subsalicylate, metronidazole, and tetracycline exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

    Helidac® comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

    Each day’s therapy is packaged in a blister card that contains 8 chewable tablets of bismuth subsalicylate, 4 tablets of metronidazole, and 4 capsules of tetracycline.

    Pay attention to how to take each medicine. Completely chew and swallow 2 bismuth tablets. Swallow the metronidazole tablets and tetracycline capsules with a full glass of water. This will help prevent irritation of the esophagus (tube between the throat and stomach). Do not chew, crush, or break the metronidazole tablets and tetracycline capsules.

    Your doctor will also prescribe another medicine, a histamine H2 receptor antagonist, which will come with its own directions and must be taken along with this combination of medicines.

    Avoid taking milk, dairy products, antacids containing aluminum, calcium, or magnesium (e.g., Maalox®, Tums®), or supplements containing iron, zinc, or sodium bicarbonate. This may keep tetracycline from working properly.

    To help clear up your infection completely, keep using bismuth subsalicylate, metronidazole, and tetracycline for the full time of treatment, even if you begin to feel better after a few days. If you stop taking bismuth subsalicylate, metronidazole, and tetracycline too soon, your symptoms may return.

    Dosing

    The dose of bismuth subsalicylate, metronidazole, and tetracycline will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of bismuth subsalicylate, metronidazole, and tetracycline. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    • For oral dosage forms (blister card containing chewable tablets, tablets, and capsules):
      • For treatment of duodenal ulcers caused by H. pylori infection:
        • Adults—One dose (525 milligrams [mg] of bismuth subsalicylate, 250 mg of metronidazole, and 500 mg of tetracycline) four times a day, taken with meals and at bedtime, for 14 days.
        • Children—Use and dose must be determined by your doctor.

    Missed dose

    If you miss a dose of bismuth subsalicylate, metronidazole, and tetracycline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    If you miss more than four doses of this combination of medicines, check with your doctor.

    Storage

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

    Keep out of the reach of children.

    Do not keep outdated medicine or medicine no longer needed.

    Ask your healthcare professional how you should dispose of any medicine you do not use.

    Precautions while using bismuth subsalicylate, metronidazole, and tetracycline

    If your condition does not improve or if it becomes worse, check with your doctor.

    Using bismuth subsalicylate, metronidazole, and tetracycline while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. Your birth control pills may not work as well while you are using bismuth subsalicylate, metronidazole, and tetracycline. If you think you have become pregnant while using bismuth subsalicylate, metronidazole, and tetracycline, tell your doctor right away.

    Do not take bismuth subsalicylate, metronidazole, and tetracycline if you are also using disulfiram (Antabuse®) or methoxyflurane (Penthrane®).

    Drinking alcoholic beverages while taking metronidazole may cause stomach pain, nausea, vomiting, headache, or flushing or redness of the face. Other alcohol-containing preparations (e.g., elixirs, cough syrups, tonics) may also cause problems. Do not drink alcoholic beverages or take other products containing propylene glycol while you are taking Helidac® and for at least 3 days after stopping it.

    Metronidazole may cause some people to become dizzy, clumsy, or trouble seeing clearly.

    Children or teenagers who have or who are recovering from chickenpox or influenza should not use this combination of medicines unless directed by the child’s doctor. If nausea or vomiting occurs after taking this combination of medicines, check with the child’s doctor.

    Tetracycline may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking tetracycline:

    • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
    • Wear protective clothing, including a hat. Also, wear sunglasses.
    • Apply a sunblock product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
    • Apply a sunblock lipstick that has an SPF of at least 15 to protect your lips.
    • Do not use a sunlamp or tanning bed or booth.

    You may still be more sensitive to sunlight or sunlamps for 2 weeks to several months or more after stopping tetracycline. If you have a severe reaction, check with your doctor.

    Bismuth subsalicylate may cause dark tongue and/or black stools. This is only temporary and will go away after you stop taking bismuth subsalicylate, metronidazole, and tetracycline.

    Bismuth subsalicylate, metronidazole, and tetracycline lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. Avoid people who are sick. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

    If you develop a skin rash, hives, or any allergic reaction to bismuth subsalicylate, metronidazole, and tetracycline, stop taking the medicine and check with your doctor as soon as possible.

    Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking tetracycline in this combination of medicines.

    Make sure any doctor or dentist who treats you knows that you are using bismuth subsalicylate, metronidazole, and tetracycline. Bismuth subsalicylate, metronidazole, and tetracycline may affect the results of certain medical tests.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

    Bismuth subsalicylate, metronidazole, and tetracycline side effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:

    More common

    • Abdominal or stomach pain
    • bloody or black, tarry stools
    • diarrhea
    • nausea

    Less common

    • Burning, prickling, or tingling sensations
    • dizziness
    • vomiting

    Rare

    • Bloody vomit
    • convulsions (seizures)
    • fainting
    • heart attack
    • irritation of the mouth or tongue
    • joint pain and swelling
    • sensitivity of the skin to sunlight
    • skin rash
    • trouble with swallowing

    Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of overdose

    • Clumsiness or unsteadiness
    • confusion
    • continuing ringing or buzzing in ears
    • fast heartbeat
    • fast or deep breathing
    • fever
    • pain, numbness, or tingling in the arms, legs, hands, or feet
    • unusual tiredness
    • vomiting

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Less common or rare

    • Burning or itching around the anus
    • constipation
    • general feeling of discomfort or illness
    • loss of appetite
    • nervousness
    • trouble sleeping

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/bismuth-subsalicylate-metronidazole-and-tetracycline.html

Using bismuth subsalicylate, metronidazole, and tetracycline with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use bismuth subsalicylate, metronidazole, and tetracycline, or give you special instructions about the use of food, alcohol, or tobacco.

  • Dairy Food

Other medical problems

The presence of other medical problems may affect the use of bismuth subsalicylate, metronidazole, and tetracycline. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to aspirin or other salicylates or
  • Kidney disease, severe—Should not be used in patients with this condition.
  • Blood disorder (e.g., leukopenia, neutropenia), or history of or
  • Brain disease or
  • Central nervous system disease or—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of metronidazole and tetracycline from the body.

Proper use of bismuth subsalicylate, metronidazole, and tetracycline

Take bismuth subsalicylate, metronidazole, and tetracycline exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Helidac® comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Each day’s therapy is packaged in a blister card that contains 8 chewable tablets of bismuth subsalicylate, 4 tablets of metronidazole, and 4 capsules of tetracycline.

Pay attention to how to take each medicine. Completely chew and swallow 2 bismuth tablets. Swallow the metronidazole tablets and tetracycline capsules with a full glass of water. This will help prevent irritation of the esophagus (tube between the throat and stomach). Do not chew, crush, or break the metronidazole tablets and tetracycline capsules.

Your doctor will also prescribe another medicine, a histamine H2 receptor antagonist, which will come with its own directions and must be taken along with this combination of medicines.

Avoid taking milk, dairy products, antacids containing aluminum, calcium, or magnesium (e.g., Maalox®, Tums®), or supplements containing iron, zinc, or sodium bicarbonate. This may keep tetracycline from working properly.

To help clear up your infection completely, keep using bismuth subsalicylate, metronidazole, and tetracycline for the full time of treatment, even if you begin to feel better after a few days. If you stop taking bismuth subsalicylate, metronidazole, and tetracycline too soon, your symptoms may return.

Dosing

The dose of bismuth subsalicylate, metronidazole, and tetracycline will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of bismuth subsalicylate, metronidazole, and tetracycline. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (blister card containing chewable tablets, tablets, and capsules):
    • For treatment of duodenal ulcers caused by H. pylori infection:
      • Adults—One dose (525 milligrams [mg] of bismuth subsalicylate, 250 mg of metronidazole, and 500 mg of tetracycline) four times a day, taken with meals and at bedtime, for 14 days.
      • Children—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of bismuth subsalicylate, metronidazole, and tetracycline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss more than four doses of this combination of medicines, check with your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using bismuth subsalicylate, metronidazole, and tetracycline

If your condition does not improve or if it becomes worse, check with your doctor.

Using bismuth subsalicylate, metronidazole, and tetracycline while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. Your birth control pills may not work as well while you are using bismuth subsalicylate, metronidazole, and tetracycline. If you think you have become pregnant while using bismuth subsalicylate, metronidazole, and tetracycline, tell your doctor right away.

Do not take bismuth subsalicylate, metronidazole, and tetracycline if you are also using disulfiram (Antabuse®) or methoxyflurane (Penthrane®).

Drinking alcoholic beverages while taking metronidazole may cause stomach pain, nausea, vomiting, headache, or flushing or redness of the face. Other alcohol-containing preparations (e.g., elixirs, cough syrups, tonics) may also cause problems. Do not drink alcoholic beverages or take other products containing propylene glycol while you are taking Helidac® and for at least 3 days after stopping it.

Metronidazole may cause some people to become dizzy, clumsy, or trouble seeing clearly.

Children or teenagers who have or who are recovering from chickenpox or influenza should not use this combination of medicines unless directed by the child’s doctor. If nausea or vomiting occurs after taking this combination of medicines, check with the child’s doctor.

Tetracycline may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking tetracycline:

  • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
  • Wear protective clothing, including a hat. Also, wear sunglasses.
  • Apply a sunblock product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
  • Apply a sunblock lipstick that has an SPF of at least 15 to protect your lips.
  • Do not use a sunlamp or tanning bed or booth.

You may still be more sensitive to sunlight or sunlamps for 2 weeks to several months or more after stopping tetracycline. If you have a severe reaction, check with your doctor.

Bismuth subsalicylate may cause dark tongue and/or black stools. This is only temporary and will go away after you stop taking bismuth subsalicylate, metronidazole, and tetracycline.

Bismuth subsalicylate, metronidazole, and tetracycline lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. Avoid people who are sick. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

If you develop a skin rash, hives, or any allergic reaction to bismuth subsalicylate, metronidazole, and tetracycline, stop taking the medicine and check with your doctor as soon as possible.

Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking tetracycline in this combination of medicines.

Make sure any doctor or dentist who treats you knows that you are using bismuth subsalicylate, metronidazole, and tetracycline. Bismuth subsalicylate, metronidazole, and tetracycline may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Bismuth subsalicylate, metronidazole, and tetracycline side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Abdominal or stomach pain
  • bloody or black, tarry stools
  • diarrhea
  • nausea

Less common

  • Burning, prickling, or tingling sensations
  • dizziness
  • vomiting

Rare

  • Bloody vomit
  • convulsions (seizures)
  • fainting
  • heart attack
  • irritation of the mouth or tongue
  • joint pain and swelling
  • sensitivity of the skin to sunlight
  • skin rash
  • trouble with swallowing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  • Clumsiness or unsteadiness
  • confusion
  • continuing ringing or buzzing in ears
  • fast heartbeat
  • fast or deep breathing
  • fever
  • pain, numbness, or tingling in the arms, legs, hands, or feet
  • unusual tiredness
  • vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Burning or itching around the anus
  • constipation
  • general feeling of discomfort or illness
  • loss of appetite
  • nervousness
  • trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Bismuth subsalicylate, metronidazole, and tetracycline (Oral)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/bismuth-subsalicylate-metronidazole-and-tetracycline.html

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