Thuốc Ado-trastuzumab emtansine (Intravenous)

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Thuốc Ado-trastuzumab emtansine (Intravenous)
Thuốc Ado-trastuzumab emtansine (Intravenous)

Holevn Health chia sẻ các bài viết về: Thuốc Ado-trastuzumab emtansine (Tiêm tĩnh mạch), tác dụng phụ – liều lượng, thuốc Ado-trastuzumab emtansine (Tiêm tĩnh mạch) điều trị bệnh gì. Vui lòng tham khảo các chi tiết dưới đây.

A-doh tras-TZ-oo-mab em-TAN-thấy

Đường truyền tĩnh mạch (Powder for Solution)

Không thay thế adt-trastuzumab emtansine bằng hoặc cho trastuzumab. Nhiễm độc gan, suy gan, giảm phân suất tống máu thất trái và tử vong đã xảy ra ở những bệnh nhân điều trị bằng ado-trastuzumab emtansine. Theo dõi chức năng gan và chức năng thất trái trước khi bắt đầu điều trị và trước mỗi liều. Sửa đổi, giữ hoặc ngừng điều trị khi cần thiết. Tiếp xúc với adt-trastuzumab emtansine trong khi mang thai có thể dẫn đến tổn hại phôi thai. Tư vấn cho bệnh nhân về những rủi ro này và sự cần thiết phải tránh thai hiệu quả.

Holevn.org xem xét y tế. Cập nhật lần cuối vào ngày 5 tháng 8 năm 2019.

Tên thương hiệu thường được sử dụng

Tại Hoa Kỳ

  • Kadcyla

Các dạng bào chế có sẵn:

  • Bột giải pháp

Lớp trị liệu: Chất chống ung thư

Lớp dược lý: Liên hợp thuốc kháng thể

Sử dụng cho adt-trastuzumab emtansine

More common

  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • decreased urine
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • dizziness
  • dry mouth
  • fever
  • frequent urge to urinate
  • headache
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nausea
  • nervousness
  • nosebleeds
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid weight gain
  • seizures
  • slow or fast heartbeat
  • sore throat
  • stomach pain
  • tightness in the chest
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • weakness in the arms, hands, legs, or feet

Less common

  • Chest pain
  • dilated neck veins
  • extreme tiredness or weakness
  • general feeling of discomfort or illness
  • irregular breathing
  • skin rash
  • thickening of bronchial secretions

Rare

  • Dark urine
  • general feeling of tiredness or weakness
  • light-colored stools
  • stomach bloating
  • vomiting blood
  • yellow eyes or skin

Incidence not known

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • decreased urine
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • dizziness
  • dry mouth
  • fever
  • frequent urge to urinate
  • headache
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nausea
  • nervousness
  • nosebleeds
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid weight gain
  • seizures
  • slow or fast heartbeat
  • sore throat
  • stomach pain
  • tightness in the chest
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • weakness in the arms, hands, legs, or feet

Less common

  • Chest pain
  • dilated neck veins
  • extreme tiredness or weakness
  • general feeling of discomfort or illness
  • irregular breathing
  • skin rash
  • thickening of bronchial secretions

Rare

  • Dark urine
  • general feeling of tiredness or weakness
  • light-colored stools
  • stomach bloating
  • vomiting blood
  • yellow eyes or skin

Incidence not known

  • Agitation
  • confusion
  • decreased awareness or responsiveness
  • depression
  • hostility
  • irritability
  • itching
  • joint pain, stiffness, or swelling
  • loss of consciousness
  • muscle twitching
  • severe sleepiness
  • stomach tenderness or cramps

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • change in taste
  • constipation
  • diarrhea
  • difficulty with moving
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss of taste
  • muscle stiffness
  • stomach discomfort or upset
  • swelling or inflammation of the mouth
  • trouble sleeping

Less common

  • Burning, dry, or itching eyes
  • discharge or excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Ado-trastuzumab emtansine (Intravenous)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/ado-trastuzumab-emtansine-intravenous.html

 

 

Receiving ado-trastuzumab emtansine while you are pregnant can harm your unborn baby. It may also cause birth defects if the father is receiving it when his sexual partner becomes pregnant. Female patients should use effective birth control during treatment with ado-trastuzumab emtansine and for 7 months after the last dose. Male patients who have female partners should use effective birth control during treatment with ado-trastuzumab emtansine and for 4 months after the last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

Check with your doctor right away if you have pain or tenderness in the upper right stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Ado-trastuzumab emtansine may cause heart failure. Your doctor may test your heart before and during treatment. Contact your doctor right away if you have chest pain, increased coughing, trouble breathing, rapid weight gain, or swelling in your ankles or legs. These could be symptoms of heart failure.

Tell your doctor right away if you are having shortness of breath, chest tightness, or any type of breathing problem while receiving ado-trastuzumab emtansine. These could be symptoms of a serious lung problem.

Ado-trastuzumab emtansine may cause a serious infusion reaction, which can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a fever, chills, chest pain, fast or uneven heartbeat, lightheadedness, dizziness, fainting, headache, rash, trouble breathing, or weakness while you receive the medicine or after the infusion.

Ado-trastuzumab emtansine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
  • Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
  • Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
  • Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
  • Avoid contact sports or other situations where bruising or injury could occur.

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

Talk with your doctor before receiving ado-trastuzumab emtansine if you plan to have children. Some men and women who receive ado-trastuzumab emtansine have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Ado-trastuzumab emtansine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • decreased urine
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • dizziness
  • dry mouth
  • fever
  • frequent urge to urinate
  • headache
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nausea
  • nervousness
  • nosebleeds
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid weight gain
  • seizures
  • slow or fast heartbeat
  • sore throat
  • stomach pain
  • tightness in the chest
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • weakness in the arms, hands, legs, or feet

Less common

  • Chest pain
  • dilated neck veins
  • extreme tiredness or weakness
  • general feeling of discomfort or illness
  • irregular breathing
  • skin rash
  • thickening of bronchial secretions

Rare

  • Dark urine
  • general feeling of tiredness or weakness
  • light-colored stools
  • stomach bloating
  • vomiting blood
  • yellow eyes or skin

Incidence not known

  • Agitation
  • confusion
  • decreased awareness or responsiveness
  • depression
  • hostility
  • irritability
  • itching
  • joint pain, stiffness, or swelling
  • loss of consciousness
  • muscle twitching
  • severe sleepiness
  • stomach tenderness or cramps

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • change in taste
  • constipation
  • diarrhea
  • difficulty with moving
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss of taste
  • muscle stiffness
  • stomach discomfort or upset
  • swelling or inflammation of the mouth
  • trouble sleeping

Less common

  • Burning, dry, or itching eyes
  • discharge or excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Seek emergency medical attention or call 115

Further information

The content of Holevn is solely for the purpose of providing information about Thuốc Ado-trastuzumab emtansine (Intravenous)  and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Please contact your nearest doctor or clinic, hospital for advice. We do not accept liability if the patient arbitrarily uses the drug without following a doctor’s prescription.

Reference from: https://www.drugs.com/cons/ado-trastuzumab-emtansine-intravenous.html

 

 

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